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    Brendan Duggan

    TitleProject Scientist
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0657
    CA La Jolla 92093
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      Collapse Biography 
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      Monash UniversityPh.D.1996Victorian College of Pharmacy

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Luzzatto-Knaan T, Garg N, Wang M, Glukhov E, Peng Y, Ackermann G, Amir A, Duggan B, Ryazanov S, Gerwick L, Knight R, Alexandrov T, Bandeira N, Gerwick WH, Dorrestein PC. Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife. 2017 May 11; 6. PMID: 28492366.
        View in: PubMed
      2. Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL, Ghequire MG, Carrion VJ, Cheng TL, Duggan B, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, Mot R, Moore BS, Medema MH, Dorrestein PC. Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nat Microbiol. 2016 Oct 31; 2:16197. PMID: 27798598.
        View in: PubMed
      3. Li ZR, Li J, Gu JP, Lai JY, Duggan B, Zhang WP, Li ZL, Li YX, Tong RB, Xu Y, Lin DH, Moore BS, Qian PY. Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin. Nat Chem Biol. 2016 Oct; 12(10):773-5. PMID: 27547923.
        View in: PubMed
      4. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan B, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 Aug 09; 34(8):828-837. PMID: 27504778.
        View in: PubMed
      5. Wang X, Duggan B, Molinski TF. Ultra-high resolution band-selective HSQC for nanomole-scale identification of chlorine-substituted 13 C in natural products drug discovery. Magn Reson Chem. 2017 Apr; 55(4):263-268. PMID: 26951950.
        View in: PubMed
      6. White AR, Duggan B, Tsai SC, Vanderwal CD. The Alga Ochromonas danica Produces Bromosulfolipids. Org Lett. 2016 Mar 04; 18(5):1124-7. PMID: 26889956.
        View in: PubMed
      7. Carling CJ, Olejniczak J, Foucault-Collet A, Collet G, Viger ML, Huu VA, Duggan B, Almutairi A. Efficient Red Light Photo-Uncaging of Active Molecules in Water Upon Assembly into Nanoparticles. Chem Sci. 2016 Mar; 7(3):2392-2398. PMID: 27014436.
        View in: PubMed
      8. Wang X, Duggan B, Molinski TF. Mollenynes B-E from the marine sponge Spirastrella mollis. Band-selective heteronuclear single quantum coherence for discrimination of bromo-chloro regioisomerism in natural products. J Am Chem Soc. 2015 Sep 30; 137(38):12343-51. PMID: 26336030.
        View in: PubMed
      9. Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan B, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick WH. Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. J Nat Prod. 2015 Jul 24; 78(7):1671-82. PMID: 26149623; PMCID: PMC4681511.
      10. Mehrotra S, Duggan B, Tello-Aburto R, Newar TD, Gerwick WH, Murray TF, Maio WA. Detailed analysis of (-)-palmyrolide a and some synthetic derivatives as voltage-gated sodium channel antagonists. J Nat Prod. 2014 Nov 26; 77(11):2553-60. PMID: 25343669; PMCID: PMC4251536.
      11. St Germain D, Denicoff AM, Dimond EP, Carrigan A, Enos RA, Gonzalez MM, Wilkinson K, Mathiason MA, Duggan B, Einolf S, McCaskill-Stevens W, Bryant DM, Thompson MA, Grubbs SS, Go RS. Use of the National Cancer Institute Community Cancer Centers Program screening and accrual log to address cancer clinical trial accrual. J Oncol Pract. 2014 Mar; 10(2):e73-80. PMID: 24424313; PMCID: PMC3948711.
      12. Kersten RD, Ziemert N, Gonzalez DJ, Duggan B, Nizet V, Dorrestein PC, Moore BS. Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4407-16. PMID: 24191063; PMCID: PMC3839717.
      13. Liu WT, Lamsa A, Wong WR, Boudreau PD, Kersten R, Peng Y, Moree WJ, Duggan B, Moore BS, Gerwick WH, Linington RG, Pogliano K, Dorrestein PC. MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. J Antibiot (Tokyo). 2014 Jan; 67(1):99-104. PMID: 24149839; PMCID: PMC3919142.
      14. Casu F, Duggan B, Hennig M. The arginine-rich RNA-binding motif of HIV-1 Rev is intrinsically disordered and folds upon RRE binding. Biophys J. 2013 Aug 20; 105(4):1004-17. PMID: 23972852; PMCID: PMC3752131.
      15. Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X, Gavilan RG, Aparicio M, Atencio L, Jackson C, Ballesteros J, Sanchez J, Watrous JD, Phelan VV, van de Wiel C, Kersten RD, Mehnaz S, De Mot R, Shank EA, Charusanti P, Nagarajan H, Duggan B, Moore BS, Bandeira N, Palsson BØ, Pogliano K, Gutiérrez M, Dorrestein PC. MS/MS networking guided analysis of molecule and gene cluster families. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):E2611-20. PMID: 23798442; PMCID: PMC3710860.
      16. Boehr DD, Schnell JR, McElheny D, Bae SH, Duggan B, Benkovic SJ, Dyson HJ, Wright PE. A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase. Biochemistry. 2013 Jul 09; 52(27):4605-19. PMID: 23758161; PMCID: PMC3838469.
      17. Kersten RD, Lane AL, Nett M, Richter TK, Duggan B, Dorrestein PC, Moore BS. Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. Chembiochem. 2013 May 27; 14(8):955-62. PMID: 23649992; PMCID: PMC3755882.
      18. Radic Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radic B, Duggan B, Ajami D, Rebek J, Taylor P. Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes. Biochem J. 2013 Feb 15; 450(1):231-42. PMID: 23216060; PMCID: PMC4772673.
      19. Watrous JD, Phelan VV, Hsu CC, Moree WJ, Duggan B, Alexandrov T, Dorrestein PC. Microbial metabolic exchange in 3D. ISME J. 2013 Apr; 7(4):770-80. PMID: 23283018; PMCID: PMC3603389.
      20. Moree WJ, Phelan VV, Wu CH, Bandeira N, Cornett DS, Duggan B, Dorrestein PC. Interkingdom metabolic transformations captured by microbial imaging mass spectrometry. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13811-6. PMID: 22869730; PMCID: PMC3427086.
      21. Duggan B, Roca A, Zhang YM. ¹H, ¹³C and ¹5N assignments of the holo-acyl carrier protein of Pseudomonas aeruginosa. Biomol NMR Assign. 2013 Oct; 7(2):225-8. PMID: 22843382; PMCID: PMC3759651.
      22. Parnham S, Gaines WA, Duggan B, Marcotte WR, Hennig M. NMR assignments of the N-terminal domain of Nephila clavipes spidroin 1. Biomol NMR Assign. 2011 Oct; 5(2):131-3. PMID: 21152998; PMCID: PMC3090696.
      23. Spence J, Duggan B, Eckhardt C, McClelland M, Mercola D. Messenger RNAs under differential translational control in Ki-ras-transformed cells. Mol Cancer Res. 2006 Jan; 4(1):47-60. PMID: 16446406.
        View in: PubMed
      24. Tan R, Jiang X, Jackson A, Jin P, Yang J, Lee E, Duggan B, Stuve LL, Fu GK. E. coli selection of human genes encoding secreted and membrane proteins based on cDNA fusions to a leaderless beta-lactamase reporter. Genome Res. 2003 Aug; 13(8):1938-43. PMID: 12869575; PMCID: PMC403786.
      25. Viles JH, Duggan B, Zaborowski E, Schwarzinger S, Huntley JJ, Kroon GJ, Dyson HJ, Wright PE. Potential bias in NMR relaxation data introduced by peak intensity analysis and curve fitting methods. J Biomol NMR. 2001 Sep; 21(1):1-9. PMID: 11693564.
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      26. Duggan B, Legge GB, Dyson HJ, Wright PE. SANE (Structure Assisted NOE Evaluation): an automated model-based approach for NOE assignment. J Biomol NMR. 2001 Apr; 19(4):321-9. PMID: 11370778.
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      27. Duggan B, Dyson HJ, Wright PE. Inherent flexibility in a potent inhibitor of blood coagulation, recombinant nematode anticoagulant protein c2. Eur J Biochem. 1999 Oct; 265(2):539-48. PMID: 10504384.
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      28. Duggan B, Craik DJ. Conformational dynamics of thyroid hormones by variable temperature nuclear magnetic resonance: the role of side chain rotations and cisoid/transoid interconversions. J Med Chem. 1997 Jul 04; 40(14):2259-65. PMID: 9216845.
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      29. Reymond MT, Huo S, Duggan B, Wright PE, Dyson HJ. Contribution of increased length and intact capping sequences to the conformational preference for helix in a 31-residue peptide from the C terminus of myohemerythrin. Biochemistry. 1997 Apr 29; 36(17):5234-44. PMID: 9136885.
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      30. Duggan B, Craik DJ. 1H and 13C NMR relaxation studies of molecular dynamics of the thyroid hormones thyroxine, 3,5,3'-triiodothyronine, and 3,5-diiodothyronine. J Med Chem. 1996 Sep 27; 39(20):4007-16. PMID: 8831766.
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      31. Dyke TR, Duggan B, Pennington MW, Byrnes ME, Kem WR, Norton RS. Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin. Biochim Biophys Acta. 1996 Jan 04; 1292(1):31-8. PMID: 8547346.
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      32. Pallaghy PK, Duggan B, Pennington MW, Norton RS. Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin. J Mol Biol. 1993 Nov 20; 234(2):405-20. PMID: 8230223.
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