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    Brandon Aubol

    TitleAssistant Project Scientist
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0636
    CA La Jolla 92093
    vCardDownload vCard

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Aubol B, Wu G, Keshwani MM, Movassat M, Fattet L, Hertel KJ, Fu XD, Adams JA. Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing. Mol Cell. 2016 Jul 21; 63(2):218-228. PMID: 27397683; PMCID: PMC4941815 [Available on 07/21/17].
      2. Serrano P, Aubol B, Keshwani MM, Forli S, Ma CT, Dutta SK, Geralt M, Wüthrich K, Adams JA. Directional Phosphorylation and Nuclear Transport of the Splicing Factor SRSF1 Is Regulated by an RNA Recognition Motif. J Mol Biol. 2016 Jun 05; 428(11):2430-45. PMID: 27091468; PMCID: PMC4884534 [Available on 06/05/17].
      3. Keshwani MM, Hailey KL, Aubol B, Fattet L, McGlone ML, Jennings PA, Adams JA. Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates. Biochem J. 2015 Dec 15; 472(3):329-38. PMID: 26443864.
        View in: PubMed
      4. Jamros MA, Aubol B, Keshwani MM, Zhang Z, Stamm S, Adams JA. Intra-domain Cross-talk Regulates Serine-arginine Protein Kinase 1-dependent Phosphorylation and Splicing Function of Transformer 2ß1. J Biol Chem. 2015 Jul 10; 290(28):17269-81. PMID: 26013829; PMCID: PMC4498066.
      5. Keshwani MM, Aubol B, Fattet L, Ma CT, Qiu J, Jennings PA, Fu XD, Adams JA. Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J. 2015 Mar 01; 466(2):311-22. PMID: 25529026.
        View in: PubMed
      6. Aubol B, Plocinik RM, Keshwani MM, McGlone ML, Hagopian JC, Ghosh G, Fu XD, Adams JA. N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation. Biochem J. 2014 Aug 15; 462(1):143-52. PMID: 24869919.
        View in: PubMed
      7. Aubol B, Adams JA. Recruiting a silent partner for activation of the protein kinase SRPK1. Biochemistry. 2014 Jul 22; 53(28):4625-34. PMID: 24984036; PMCID: PMC4108178.
      8. Aubol B, Jamros MA, McGlone ML, Adams JA. Splicing kinase SRPK1 conforms to the landscape of its SR protein substrate. Biochemistry. 2013 Oct 29; 52(43):7595-605. PMID: 24074032; PMCID: PMC3865722.
      9. Aubol B, Plocinik RM, Hagopian JC, Ma CT, McGlone ML, Bandyopadhyay R, Fu XD, Adams JA. Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases. J Mol Biol. 2013 Aug 23; 425(16):2894-909. PMID: 23707382; PMCID: PMC3860265.
      10. Zhou X, Chou TF, Aubol B, Park CJ, Wolfenden R, Adams J, Wagner CR. Kinetic mechanism of human histidine triad nucleotide binding protein 1. Biochemistry. 2013 May 21; 52(20):3588-600. PMID: 23614568; PMCID: PMC3835729.
      11. Aubol B, Plocinik RM, McGlone ML, Adams JA. Nucleotide release sequences in the protein kinase SRPK1 accelerate substrate phosphorylation. Biochemistry. 2012 Aug 21; 51(33):6584-94. PMID: 22839969; PMCID: PMC3718016.
      12. Sumanasekera C, Kelemen O, Beullens M, Aubol B, Adams JA, Sunkara M, Morris A, Bollen M, Andreadis A, Stamm S. C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1. Nucleic Acids Res. 2012 May; 40(9):4025-39. PMID: 22210893; PMCID: PMC3351148.
      13. Aubol B, Adams JA. Applying the brakes to multisite SR protein phosphorylation: substrate-induced effects on the splicing kinase SRPK1. Biochemistry. 2011 Aug 16; 50(32):6888-900. PMID: 21728354; PMCID: PMC3153611.
      14. Buchanan SG, Hendle J, Lee PS, Smith CR, Bounaud PY, Jessen KA, Tang CM, Huser NH, Felce JD, Froning KJ, Peterman MC, Aubol B, Gessert SF, Sauder JM, Schwinn KD, Russell M, Rooney IA, Adams J, Leon BC, Do TH, Blaney JM, Sprengeler PA, Thompson DA, Smyth L, Pelletier LA, Atwell S, Holme K, Wasserman SR, Emtage S, Burley SK, Reich SH. SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol Cancer Ther. 2009 Dec; 8(12):3181-90. PMID: 19934279.
        View in: PubMed
      15. Antonysamy SS, Aubol B, Blaney J, Browner MF, Giannetti AM, Harris SF, Hébert N, Hendle J, Hopkins S, Jefferson E, Kissinger C, Leveque V, Marciano D, McGee E, Nájera I, Nolan B, Tomimoto M, Torres E, Wright T. Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg Med Chem Lett. 2008 May 01; 18(9):2990-5. PMID: 18400495.
        View in: PubMed
      16. Ngo JC, Chakrabarti S, Ding JH, Velazquez-Dones A, Nolen B, Aubol B, Adams JA, Fu XD, Ghosh G. Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol Cell. 2005 Oct 07; 20(1):77-89. PMID: 16209947.
        View in: PubMed
      17. Lieser SA, Aubol B, Wong L, Jennings PA, Adams JA. Coupling phosphoryl transfer and substrate interactions in protein kinases. Biochim Biophys Acta. 2005 Dec 30; 1754(1-2):191-9. PMID: 16213199.
        View in: PubMed
      18. Lieser SA, Shindler C, Aubol B, Lee S, Sun G, Adams JA. Phosphoryl transfer step in the C-terminal Src kinase controls Src recognition. J Biol Chem. 2005 Mar 04; 280(9):7769-76. PMID: 15623523.
        View in: PubMed
      19. Wong L, Lieser S, Chie-Leon B, Miyashita O, Aubol B, Shaffer J, Onuchic JN, Jennings PA, Woods VL, Adams JA. Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk. J Mol Biol. 2004 Jul 30; 341(1):93-106. PMID: 15312765.
        View in: PubMed
      20. Aubol B, Ungs L, Lukasiewicz R, Ghosh G, Adams JA. Chemical clamping allows for efficient phosphorylation of the RNA carrier protein Npl3. J Biol Chem. 2004 Jul 16; 279(29):30182-8. PMID: 15145958.
        View in: PubMed
      21. Aubol B, Nolen B, Shaffer J, Ghosh G, Adams JA. Novel destabilization of nucleotide binding by the gamma phosphate of ATP in the yeast SR protein kinase Sky1p. Biochemistry. 2003 Nov 11; 42(44):12813-20. PMID: 14596595.
        View in: PubMed
      22. Aubol B, Chakrabarti S, Ngo J, Shaffer J, Nolen B, Fu XD, Ghosh G, Adams JA. Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12601-6. PMID: 14555757; PMCID: PMC240664.
      23. Aubol B, Reich NO. Murine DNA cytosine C(5)-methyltransferase: in vitro studies of de novo methylation spreading. Biochem Biophys Res Commun. 2003 Oct 10; 310(1):209-14. PMID: 14511672.
        View in: PubMed
      24. Aubol B, Nolen B, Vu D, Ghosh G, Adams JA. Mechanistic insights into Sky1p, a yeast homologue of the mammalian SR protein kinases. Biochemistry. 2002 Aug 06; 41(31):10002-9. PMID: 12146964.
        View in: PubMed