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    Bradley Moore

    TitleAssociate Director
    SchoolUniversity of California, San Diego
    DepartmentCenter for Marine Biotechnology and Biomedecine
    Address9500 Gilman Drive #0204
    CA La Jolla 92093
    Phone858-822-6650
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Targeted discovery of antibiotics from cave bacteria
      NIH/NIAID R01AI117712Mar 1, 2016 - Feb 28, 2020
      Role: Principal Investigator
      Scripps Center for Ocean and Human Health
      NIH/NIEHS P01ES021921Sep 24, 2012 - Jul 31, 2017
      Role: Principal Investigator
      Experiment based genome mining of ribosomal natural products
      NIH/NIGMS R01GM097509Apr 1, 2012 - Feb 29, 2016
      Role: Principal Investigator
      Natural Product Genome Mining
      NIH/NIGMS R01GM085770Aug 1, 2009 - Jul 31, 2021
      Role: Principal Investigator
      Salinosporamide Biosynthesis and Engineering
      NIH/NCI R01CA127622Apr 1, 2007 - May 31, 2017
      Role: Principal Investigator
      Type III Polyketide Synthases: Structure and Mechanism
      NIH/NIAID R01AI052443Jun 15, 2002 - May 31, 2008
      Role: Principal Investigator
      Biosynthesis of Marine Polyketide Antibiotics
      NIH/NIAID R56AI047818Aug 1, 2000 - Aug 31, 2018
      Role: Principal Investigator
      Biosynthesis of marine polyketide antibiotics
      NIH/NIAID R01AI047818Aug 1, 2000 - Feb 28, 2017
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Li J, Tang X, Awakawa T, Moore B. Enzymatic C-H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity. Angew Chem Int Ed Engl. 2017 Sep 25; 56(40):12234-12239. PMID: 28833969.
        View in: PubMed
      2. Moore B, Carter GT, Brönstrup M. Editorial: Are natural products the solution to antimicrobial resistance? Nat Prod Rep. 2017 07 01; 34(7):685-686. PMID: 28671218.
        View in: PubMed
      3. Tang X, Li J, Moore B. Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation. Chembiochem. 2017 Jun 19; 18(12):1072-1076. PMID: 28393452.
        View in: PubMed
      4. Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore B. Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. Nat Chem Biol. 2017 May; 13(5):537-543. PMID: 28319100.
        View in: PubMed
      5. Agarwal V, Miles ZD, Winter JM, Eustáquio AS, El Gamal AA, Moore B. Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse. Chem Rev. 2017 Apr 26; 117(8):5619-5674. PMID: 28106994.
        View in: PubMed
      6. Jordan PA, Moore B. Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids. Cell Chem Biol. 2016 Dec 22; 23(12):1504-1514. PMID: 27866908.
        View in: PubMed
      7. Schorn MA, Alanjary MM, Aguinaldo K, Korobeynikov A, Podell S, Patin N, Lincecum T, Jensen PR, Ziemert N, Moore B. Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters. Microbiology. 2016 Dec; 162(12):2075-2086. PMID: 27902408.
        View in: PubMed
      8. El Gamal A, Agarwal V, Rahman I, Moore B. Enzymatic Reductive Dehalogenation Controls the Biosynthesis of Marine Bacterial Pyrroles. J Am Chem Soc. 2016 Oct 12; 138(40):13167-13170. PMID: 27676265.
        View in: PubMed
      9. Li ZR, Li J, Gu JP, Lai JY, Duggan BM, Zhang WP, Li ZL, Li YX, Tong RB, Xu Y, Lin DH, Moore B, Qian PY. Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin. Nat Chem Biol. 2016 Oct; 12(10):773-5. PMID: 27547923.
        View in: PubMed
      10. El Gamal A, Agarwal V, Diethelm S, Rahman I, Schorn MA, Sneed JM, Louie GV, Whalen KE, Mincer TJ, Noel JP, Paul VJ, Moore B. Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):3797-802. PMID: 27001835; PMCID: PMC4833250 [Available on 10/05/16].
      11. Harvey EL, Deering RW, Rowley DC, El Gamal A, Schorn M, Moore B, Johnson MD, Mincer TJ, Whalen KE. A Bacterial Quorum-Sensing Precursor Induces Mortality in the Marine Coccolithophore, Emiliania huxleyi. Front Microbiol. 2016; 7:59. PMID: 26870019; PMCID: PMC4737879.
      12. Ray L, Moore B. Recent advances in the biosynthesis of unusual polyketide synthase substrates. Nat Prod Rep. 2016 Feb; 33(2):150-61. PMID: 26571143; PMCID: PMC4742410 [Available on 02/04/17].
      13. Teufel R, Agarwal V, Moore B. Unusual flavoenzyme catalysis in marine bacteria. Curr Opin Chem Biol. 2016 Apr; 31:31-9. PMID: 26803009; PMCID: PMC4870101 [Available on 04/01/17].
      14. Ray L, Yamanaka K, Moore B. A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis. Angew Chem Int Ed Engl. 2016 Jan 04; 55(1):364-7. PMID: 26553755; PMCID: PMC4715598 [Available on 01/04/17].
      15. Kim E, Moore B, Yoon YJ. Erratum: Reinvigorating natural product combinatorial biosynthesis with synthetic biology. Nat Chem Biol. 2015 Nov; 11(11):887. PMID: 26485082.
        View in: PubMed
      16. Agarwal V, Diethelm S, Ray L, Garg N, Awakawa T, Dorrestein PC, Moore B. Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins. Org Lett. 2015 Sep 18; 17(18):4452-5. PMID: 26333306; PMCID: PMC4720141.
      17. Kim E, Moore B, Yoon YJ. Reinvigorating natural product combinatorial biosynthesis with synthetic biology. Nat Chem Biol. 2015 Sep; 11(9):649-59. PMID: 26284672; PMCID: PMC4757526.
      18. Teufel R, Stull F, Meehan MJ, Michaudel Q, Dorrestein PC, Palfey B, Moore B. Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor. J Am Chem Soc. 2015 Jul 01; 137(25):8078-85. PMID: 26067765; PMCID: PMC4720136.
      19. Awakawa T, Crüsemann M, Munguia J, Ziemert N, Nizet V, Fenical W, Moore B. Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase. Chembiochem. 2015 Jul 06; 16(10):1443-7. PMID: 25930739; PMCID: PMC4545249.
      20. Jensen PR, Moore B, Fenical W. The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. Nat Prod Rep. 2015 May; 32(5):738-51. PMID: 25730728; PMCID: PMC4414829.
      21. Duncan KR, Crüsemann M, Lechner A, Sarkar A, Li J, Ziemert N, Wang M, Bandeira N, Moore B, Dorrestein PC, Jensen PR. Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chem Biol. 2015 Apr 23; 22(4):460-471. PMID: 25865308; PMCID: PMC4409930.
      22. Moore B, Gerwick WH. Special issue in honor of William Fenical, a pioneer in marine natural products discovery and drug development. J Nat Prod. 2015 Mar 27; 78(3):347-8. PMID: 25814030.
        View in: PubMed
      23. Zhang JJ, Moore B. Digging for biosynthetic dark matter. Elife. 2015 Feb 13; 4:e06453. PMID: 25687291; PMCID: PMC4337655.
      24. Agarwal V, Li J, Rahman I, Borgen M, Aluwihare LI, Biggs JS, Paul VJ, Moore B. Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry. Environ Sci Technol. 2015 Feb 03; 49(3):1339-46. PMID: 25559102; PMCID: PMC4358748.
      25. Bonet B, Teufel R, Crüsemann M, Ziemert N, Moore B. Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin. J Nat Prod. 2015 Mar 27; 78(3):539-42. PMID: 25382643; PMCID: PMC4380194.
      26. Diethelm S, Teufel R, Kaysser L, Moore B. A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins. Angew Chem Int Ed Engl. 2014 Oct 06; 53(41):11023-6. PMID: 25147132; PMCID: PMC4226426.
      27. Teufel R, Kaysser L, Villaume MT, Diethelm S, Carbullido MK, Baran PS, Moore B. One-pot enzymatic synthesis of merochlorin A and B. Angew Chem Int Ed Engl. 2014 Oct 06; 53(41):11019-22. PMID: 25115835; PMCID: PMC4229033.
      28. Agarwal V, Moore B. Fungal polyketide engineering comes of age. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12278-9. PMID: 25118274; PMCID: PMC4151771.
      29. Mohimani H, Liu WT, Kersten RD, Moore B, Dorrestein PC, Pevzner PA. NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide Discovery. J Nat Prod. 2014 Aug 22; 77(8):1902-9. PMID: 25116163; PMCID: PMC4143176.
      30. Agarwal V, Moore B. Enzymatic synthesis of polybrominated dioxins from the marine environment. ACS Chem Biol. 2014 Sep 19; 9(9):1980-4. PMID: 25061970; PMCID: PMC4168793.
      31. Agarwal V, El Gamal AA, Yamanaka K, Poth D, Kersten RD, Schorn M, Allen EE, Moore B. Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. Nat Chem Biol. 2014 Aug; 10(8):640-7. PMID: 24974229; PMCID: PMC4104138.
      32. Trivella DB, Pereira AR, Stein ML, Kasai Y, Byrum T, Valeriote FA, Tantillo DJ, Groll M, Gerwick WH, Moore B. Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem Biol. 2014 Jun 19; 21(6):782-91. PMID: 24930969; PMCID: PMC4103027.
      33. Mohimani H, Kersten RD, Liu WT, Wang M, Purvine SO, Wu S, Brewer HM, Pasa-Tolic L, Bandeira N, Moore B, Pevzner PA, Dorrestein PC. Automated genome mining of ribosomal peptide natural products. ACS Chem Biol. 2014 Jul 18; 9(7):1545-51. PMID: 24802639; PMCID: PMC4215869.
      34. Niewerth D, Jansen G, Riethoff LF, van Meerloo J, Kale AJ, Moore B, Assaraf YG, Anderl JL, Zweegman S, Kaspers GJ, Cloos J. Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib). Mol Pharmacol. 2014 Jul; 86(1):12-9. PMID: 24737138; PMCID: PMC4054006.
      35. Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore B. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1957-62. PMID: 24449899; PMCID: PMC3918841.
      36. Jordan PA, Moore B. Biosynthesis: Non-stick natural products. Nat Chem. 2014 Jan; 6(1):10-2. PMID: 24345935.
        View in: PubMed
      37. Mantovani SM, Moore B. Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine A. J Am Chem Soc. 2013 Dec 04; 135(48):18032-5. PMID: 24246014; PMCID: PMC3887146.
      38. Schorn M, Zettler J, Noel JP, Dorrestein PC, Moore B, Kaysser L. Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. ACS Chem Biol. 2014 Jan 17; 9(1):301-9. PMID: 24168704; PMCID: PMC4041076.
      39. Liu WT, Lamsa A, Wong WR, Boudreau PD, Kersten R, Peng Y, Moree WJ, Duggan BM, Moore B, Gerwick WH, Linington RG, Pogliano K, Dorrestein PC. MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. J Antibiot (Tokyo). 2014 Jan; 67(1):99-104. PMID: 24149839; PMCID: PMC3919142.
      40. Jensen PR, Chavarria KL, Fenical W, Moore B, Ziemert N. Challenges and triumphs to genomics-based natural product discovery. J Ind Microbiol Biotechnol. 2014 Feb; 41(2):203-9. PMID: 24104399; PMCID: PMC3946964.
      41. Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X, Gavilan RG, Aparicio M, Atencio L, Jackson C, Ballesteros J, Sanchez J, Watrous JD, Phelan VV, van de Wiel C, Kersten RD, Mehnaz S, De Mot R, Shank EA, Charusanti P, Nagarajan H, Duggan BM, Moore B, Bandeira N, Palsson BØ, Pogliano K, Gutiérrez M, Dorrestein PC. MS/MS networking guided analysis of molecule and gene cluster families. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):E2611-20. PMID: 23798442; PMCID: PMC3710860.
      42. Lipson JM, Thomsen M, Moore B, Clausen RP, La Clair JJ, Burkart MD. A tandem chemoenzymatic methylation by S-adenosyl-L-methionine. Chembiochem. 2013 May 27; 14(8):950-3. PMID: 23650044; PMCID: PMC3749784.
      43. Kersten RD, Lane AL, Nett M, Richter TK, Duggan BM, Dorrestein PC, Moore B. Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. Chembiochem. 2013 May 27; 14(8):955-62. PMID: 23649992; PMCID: PMC3755882.
      44. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore B, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013 Jan; 30(1):108-60. PMID: 23165928; PMCID: PMC3954855.
      45. Lechner A, Wilson MC, Ban YH, Hwang JY, Yoon YJ, Moore B. Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering. ACS Synth Biol. 2013 Jul 19; 2(7):379-83. PMID: 23654255; PMCID: PMC3716868.
      46. Roberts AA, Schultz AW, Kersten RD, Dorrestein PC, Moore B. Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores. FEMS Microbiol Lett. 2012 Oct; 335(2):95-103. PMID: 22812504; PMCID: PMC4209017.
      47. Yang JY, Phelan VV, Simkovsky R, Watrous JD, Trial RM, Fleming TC, Wenter R, Moore B, Golden SS, Pogliano K, Dorrestein PC. Primer on agar-based microbial imaging mass spectrometry. J Bacteriol. 2012 Nov; 194(22):6023-8. PMID: 22821974; PMCID: PMC3486372.
      48. Kaysser L, Bernhardt P, Nam SJ, Loesgen S, Ruby JG, Skewes-Cox P, Jensen PR, Fenical W, Moore B. Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases. J Am Chem Soc. 2012 Jul 25; 134(29):11988-91. PMID: 22784372; PMCID: PMC3410959.
      49. Watrous J, Roach P, Alexandrov T, Heath BS, Yang JY, Kersten RD, van der Voort M, Pogliano K, Gross H, Raaijmakers JM, Moore B, Laskin J, Bandeira N, Dorrestein PC. Mass spectral molecular networking of living microbial colonies. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):E1743-52. PMID: 22586093; PMCID: PMC3387089.
      50. Pereira AR, Kale AJ, Fenley AT, Byrum T, Debonsi HM, Gilson MK, Valeriote FA, Moore B, Gerwick WH. The carmaphycins: new proteasome inhibitors exhibiting an a,ß-epoxyketone warhead from a marine cyanobacterium. Chembiochem. 2012 Apr 16; 13(6):810-7. PMID: 22383253; PMCID: PMC3393770.
      51. Jones AC, Ottilie S, Eustáquio AS, Edwards DJ, Gerwick L, Moore B, Gerwick WH. Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS J. 2012 Apr; 279(7):1243-51. PMID: 22314229.
        View in: PubMed
      52. Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore B, Horswill AR, Dixon JE, Dorrestein PC, Nizet V. Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem. 2012 Apr 20; 287(17):13889-98. PMID: 22371493; PMCID: PMC3340166.
      53. Lechner A, Eustáquio AS, Gulder TA, Hafner M, Moore B. Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation. Chem Biol. 2011 Dec 23; 18(12):1527-36. PMID: 22195555; PMCID: PMC3246214.
      54. Wilson MC, Moore B. Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. Nat Prod Rep. 2012 Jan; 29(1):72-86. PMID: 22124767.
        View in: PubMed
      55. Liu WT, Kersten RD, Yang YL, Moore B, Dorrestein PC. Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus. J Am Chem Soc. 2011 Nov 16; 133(45):18010-3. PMID: 21999343; PMCID: PMC3251218.
      56. Kersten RD, Yang YL, Xu Y, Cimermancic P, Nam SJ, Fenical W, Fischbach MA, Moore B, Dorrestein PC. A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol. 2011 Oct 09; 7(11):794-802. PMID: 21983601; PMCID: PMC3258187.
      57. Kale AJ, McGlinchey RP, Lechner A, Moore B. Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. ACS Chem Biol. 2011 Nov 18; 6(11):1257-64. PMID: 21882868; PMCID: PMC3220761.
      58. Miyanaga A, Janso JE, McDonald L, He M, Liu H, Barbieri L, Eustáquio AS, Fielding EN, Carter GT, Jensen PR, Feng X, Leighton M, Koehn FE, Moore B. Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria. J Am Chem Soc. 2011 Aug 31; 133(34):13311-3. PMID: 21815669; PMCID: PMC3161154.
      59. Yang YL, Xu Y, Kersten RD, Liu WT, Meehan MJ, Moore B, Bandeira N, Dorrestein PC. Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry. Angew Chem Int Ed Engl. 2011 Jun 20; 50(26):5839-42. PMID: 21574228; PMCID: PMC3687529.
      60. Kalaitzis JA, Cheng Q, Meluzzi D, Xiang L, Izumikawa M, Dorrestein PC, Moore B. Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. Bioorg Med Chem. 2011 Nov 15; 19(22):6633-8. PMID: 21531566; PMCID: PMC3162089.
      61. Udwary DW, Gontang EA, Jones AC, Jones CS, Schultz AW, Winter JM, Yang JY, Beauchemin N, Capson TL, Clark BR, Esquenazi E, Eustáquio AS, Freel K, Gerwick L, Gerwick WH, Gonzalez D, Liu WT, Malloy KL, Maloney KN, Nett M, Nunnery JK, Penn K, Prieto-Davo A, Simmons TL, Weitz S, Wilson MC, Tisa LS, Dorrestein PC, Moore B. Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Appl Environ Microbiol. 2011 Jun; 77(11):3617-25. PMID: 21498757; PMCID: PMC3127629.
      62. Bernhardt P, Okino T, Winter JM, Miyanaga A, Moore B. A stereoselective vanadium-dependent chloroperoxidase in bacterial antibiotic biosynthesis. J Am Chem Soc. 2011 Mar 30; 133(12):4268-70. PMID: 21384874; PMCID: PMC3065929.
      63. Wilson MC, Nam SJ, Gulder TA, Kauffman CA, Jensen PR, Fenical W, Moore B. Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. J Am Chem Soc. 2011 Feb 16; 133(6):1971-7. PMID: 21247149; PMCID: PMC3091981.
      64. Eustáquio AS, Nam SJ, Penn K, Lechner A, Wilson MC, Fenical W, Jensen PR, Moore B. The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. Chembiochem. 2011 Jan 03; 12(1):61-4. PMID: 21154492; PMCID: PMC3088357.
      65. Mo S, Kim DH, Lee JH, Park JW, Basnet DB, Ban YH, Yoo YJ, Chen SW, Park SR, Choi EA, Kim E, Jin YY, Lee SK, Park JY, Liu Y, Lee MO, Lee KS, Kim SJ, Kim D, Park BC, Lee SG, Kwon HJ, Suh JW, Moore B, Lim SK, Yoon YJ. Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. J Am Chem Soc. 2011 Feb 02; 133(4):976-85. PMID: 21175203; PMCID: PMC3030623.
      66. Lane AL, Moore B. A sea of biosynthesis: marine natural products meet the molecular age. Nat Prod Rep. 2011 Feb; 28(2):411-28. PMID: 21170424; PMCID: PMC3101795.
      67. Gulder TA, Moore B. Salinosporamide natural products: Potent 20?S proteasome inhibitors as promising cancer chemotherapeutics. Angew Chem Int Ed Engl. 2010 Dec 03; 49(49):9346-67. PMID: 20927786; PMCID: PMC3103133.
      68. Kale AJ, McGlinchey RP, Moore B. Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling. J Biol Chem. 2010 Oct 29; 285(44):33710-7. PMID: 20736169; PMCID: PMC2962469.
      69. Eustáquio AS, O'Hagan D, Moore B. Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide. J Nat Prod. 2010 Mar 26; 73(3):378-82. PMID: 20085308; PMCID: PMC2846182.
      70. Schultz AW, Lewis CA, Luzung MR, Baran PS, Moore B. Functional characterization of the cyclomarin/cyclomarazine prenyltransferase CymD directs the biosynthesis of unnatural cyclic peptides. J Nat Prod. 2010 Mar 26; 73(3):373-7. PMID: 20055491; PMCID: PMC2846197.
      71. Roberts AA, Ryan KS, Moore B, Gulder TA. Total (bio)synthesis: strategies of nature and of chemists. Top Curr Chem. 2010; 297:149-203. PMID: 21495259; PMCID: PMC3109256.
      72. Deng H, McMahon SA, Eustáquio AS, Moore B, Naismith JH, O'Hagan D. Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62). Chembiochem. 2009 Oct 12; 10(15):2455-9. PMID: 19739191; PMCID: PMC3063057.
      73. Nett M, Gulder TA, Kale AJ, Hughes CC, Moore B. Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. J Med Chem. 2009 Oct 08; 52(19):6163-7. PMID: 19746976; PMCID: PMC2771571.
      74. Nett M, Ikeda H, Moore B. Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep. 2009 Nov; 26(11):1362-84. PMID: 19844637; PMCID: PMC3063060.
      75. Liu Y, Hazzard C, Eustáquio AS, Reynolds KA, Moore B. Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity. J Am Chem Soc. 2009 Aug 05; 131(30):10376-7. PMID: 19601645; PMCID: PMC2737082.
      76. Eustáquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore B. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12295-300. PMID: 19590008; PMCID: PMC2718359.
      77. Liu WT, Ng J, Meluzzi D, Bandeira N, Gutierrez M, Simmons TL, Schultz AW, Linington RG, Moore B, Gerwick WH, Pevzner PA, Dorrestein PC. Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Anal Chem. 2009 Jun 01; 81(11):4200-9. PMID: 19413302; PMCID: PMC2765223.
      78. Penn K, Jenkins C, Nett M, Udwary DW, Gontang EA, McGlinchey RP, Foster B, Lapidus A, Podell S, Allen EE, Moore B, Jensen PR. Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. ISME J. 2009 Oct; 3(10):1193-203. PMID: 19474814; PMCID: PMC2749086.
      79. Ryan KS, Moore B. Alkaloid biosynthesis takes root. Nat Chem Biol. 2009 Mar; 5(3):140-1. PMID: 19219013.
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      80. Winter JM, Jansma AL, Handel TM, Moore B. Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone. Angew Chem Int Ed Engl. 2009; 48(4):767-70. PMID: 19072974; PMCID: PMC3517086.
      81. Eustáquio AS, Härle J, Noel JP, Moore B. S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. Chembiochem. 2008 Sep 22; 9(14):2215-9. PMID: 18720493; PMCID: PMC2692205.
      82. Worthington AS, Hur GH, Meier JL, Cheng Q, Moore B, Burkart MD. Probing the compatibility of type II ketosynthase-carrier protein partners. Chembiochem. 2008 Sep 01; 9(13):2096-103. PMID: 18666307; PMCID: PMC2994244.
      83. Moore B, Eustáquio AS, McGlinchey RP. Advances in and applications of proteasome inhibitors. Curr Opin Chem Biol. 2008 Aug; 12(4):434-40. PMID: 18656549; PMCID: PMC2560982.
      84. McGlinchey RP, Nett M, Eustáquio AS, Asolkar RN, Fenical W, Moore B. Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. J Am Chem Soc. 2008 Jun 25; 130(25):7822-3. PMID: 18512922; PMCID: PMC2814216.
      85. McGlinchey RP, Nett M, Moore B. Unraveling the biosynthesis of the sporolide cyclohexenone building block. J Am Chem Soc. 2008 Feb 27; 130(8):2406-7. PMID: 18232689.
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      86. Eustáquio AS, Moore B. Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew Chem Int Ed Engl. 2008; 47(21):3936-8. PMID: 18407559.
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      87. Moore B. Extending the biosynthetic repertoire in ribosomal peptide assembly. Angew Chem Int Ed Engl. 2008; 47(49):9386-8. PMID: 18846537.
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      88. Eustáquio AS, Pojer F, Noel JP, Moore B. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat Chem Biol. 2008 Jan; 4(1):69-74. PMID: 18059261; PMCID: PMC2762381.
      89. Cheng Q, Xiang L, Izumikawa M, Meluzzi D, Moore B. Enzymatic total synthesis of enterocin polyketides. Nat Chem Biol. 2007 Sep; 3(9):557-8. PMID: 17704772.
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      90. Udwary DW, Zeigler L, Asolkar RN, Singan V, Lapidus A, Fenical W, Jensen PR, Moore B. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10376-81. PMID: 17563368; PMCID: PMC1965521.
      91. Beer LL, Moore B. Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. Org Lett. 2007 Mar 01; 9(5):845-8. PMID: 17274624.
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      92. Moffitt MC, Louie GV, Bowman ME, Pence J, Noel JP, Moore B. Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. Biochemistry. 2007 Jan 30; 46(4):1004-12. PMID: 17240984; PMCID: PMC2586389.
      93. Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore B, Noel JP. Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chem Biol. 2006 Dec; 13(12):1327-38. PMID: 17185228; PMCID: PMC2859959.
      94. Song L, Barona-Gomez F, Corre C, Xiang L, Udwary DW, Austin MB, Noel JP, Moore B, Challis GL. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J Am Chem Soc. 2006 Nov 22; 128(46):14754-5. PMID: 17105255; PMCID: PMC2859292.
      95. Austin MB, Saito T, Bowman ME, Haydock S, Kato A, Moore B, Kay RR, Noel JP. Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nat Chem Biol. 2006 Sep; 2(9):494-502. PMID: 16906151; PMCID: PMC2864586.
      96. Moore B. Biosynthesis of marine natural products: macroorganisms (Part B). Nat Prod Rep. 2006 Aug; 23(4):615-29. PMID: 16874392.
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      97. Moore B. Biosynthesis of marine natural products: microorganisms (Part A). Nat Prod Rep. 2005 Oct; 22(5):580-93. PMID: 16193157.
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      98. Kalaitzis JA, Moore B. Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase. J Nat Prod. 2004 Aug; 67(8):1419-22. PMID: 15332868.
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      99. Austin MB, Izumikawa M, Bowman ME, Udwary DW, Ferrer JL, Moore B, Noel JP. Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. J Biol Chem. 2004 Oct 22; 279(43):45162-74. PMID: 15265863.
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      100. Hertweck C, Xiang L, Kalaitzis JA, Cheng Q, Palzer M, Moore B. Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction. Chem Biol. 2004 Apr; 11(4):461-8. PMID: 15123240.
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      101. Becker JE, Moore RE, Moore B. Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization. Gene. 2004 Jan 21; 325:35-42. PMID: 14697508.
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      102. Izumikawa M, Shipley PR, Hopke JN, O'Hare T, Xiang L, Noel JP, Moore B. Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). J Ind Microbiol Biotechnol. 2003 Aug; 30(8):510-5. PMID: 12905073.
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      103. Hoffmann D, Hevel JM, Moore RE, Moore B. Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224. Gene. 2003 Jun 05; 311:171-80. PMID: 12853152.
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      104. Moore B, Hertweck C, Hopke JN, Izumikawa M, Kalaitzis JA, Nilsen G, O'Hare T, Piel J, Shipley PR, Xiang L, Austin MB, Noel JP. Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. J Nat Prod. 2002 Dec; 65(12):1956-62. PMID: 12502351.
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      105. Moore B, Hertweck C. Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Nat Prod Rep. 2002 Feb; 19(1):70-99. PMID: 11902441.
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