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    Barbara Parry

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentPsychiatry
    Address9500 Gilman Drive #0804
    CA La Jolla 92093
    Phone619-543-5592
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      Biography

      Barbara L. Parry, M.D. is Professor of Psychiatry at the University of California, San Diego (UCSD) where she has served as Director of the Women’s Mood Disorders Clinic of the UCSD Outpatient Psychiatric Services, Director of the Women’s Mental Health Clinic at the San Diego Veterans Administration Healthcare Center and Associate Director of the Medical Student Clerkship in Psychiatry. Before joining the faculty at UCSD in 1985, she did a research fellowship in Clinical Psychobiology at the National Institute of Mental Health in Bethesda, Maryland. She completed a residency in Psychiatry and an internship in Internal Medicine at the University of California, Los Angeles. Her clinical research focus is the chronobiology of mood disorders specific to women: premenstrual, pregnancy/postpartum and menopausal depression. She conducts sleep, light, melatonin and other hormonal studies with the aim of developing non-pharmacological approaches to treatment. Her work is supported by NIH funding, she has authored or co-authored over 280 publications and served on NIH study sections, Data and Safety Monitoring Boards and the editorial boards of the American Journal of Psychiatry, the Journal of Biological Rhythms, the International Journal of Endocrinology and Equilibria, the Journal for Postpartum Psychiatric Illness Research.

      Research Interests

      My research and clinical background is in women’s mood disorders related to the reproductive cycle, and in chronobiology: With regard to my background in women’s mood disorders, as a medical student, I published a manuscript on the biologic basis of oral contraceptive-induced depressions (Mentor: A. John Rush, M.D.); as a psychiatric resident at the University of California, Los Angeles, I initiated, and subsequently published, a study on cerebrospinal fluid and endocrine measures in Premenstrual Dysphoric Disorder-PMDD (Mentor: Robert Gerner, M.D.). I continued my studies of women’s mood disorders at the NIH, expanding into its chronobiological aspects, and for the last 29 years since coming to UCSD have extended the endocrine and chronobiological investigations in PMDD to other depressive disorders related to the reproductive cycle in women (pregnancy, postpartum, menopause). With regard to chronobiology, I did a research fellowship in Clinical Chronobiology at the National Institute of Mental Health (Mentors: Frederick K. Goodwin, M.D., Thomas A. Wehr, M.D. and Norman E. Rosenthal, M.D.), where as a clinical research associate I helped to implement studies primarily of melatonin circadian rhythms and of sleep and light therapies in mood disorders (rapid cycling bipolar illness and seasonal affective disorder) and initiated my own studies on melatonin circadian rhythms, sleep and light therapies in PMDD. Since joining the faculty in the Department of Psychiatry at the University of California, San Diego (UCSD) in 1985, I have extended the studies of melatonin and other hormones (cortisol, thyroid, prolactin, estradiol, progesterone, gonadotrophins) and of sleep and light therapies to not only PMDD, but also to pregnancy, postpartum and menopausal depressive disorders (Collaborators: J. Christian Gillin, M.D., Daniel F. Kripke, M.D., Richard L. Hauger, M.D., Jeffrey A. Elliott, Ph.D., Sonia Ancoli-Israel, Ph.D.). I served on the American Psychiatric Association’s DSM-III-R and DSM-IV committees to develop diagnostic criteria for PMDD (and as a consultant for postpartum mood disorders), the Advisory Panel for the Surgeon General’s Women’s Mental Health Project, the NIH Office of Research for Women’s Health: Planning the Women’s Health Agenda for the 21st Century and the Executive Board of the Marce’ Society, The International Society for the Study and Treatment of Mental Illness during Childbearing. In these areas pertaining to the chronobiology of women’s mood disorders, I have published over 285 publications, maintained a consistent level of funding support through primarily NIH and other sources as PI, served as a reviewer on study sections, special emphasis panels, stimulus package grant applications and Data and Safety Monitoring Boards, and been on the editorial boards of multiple journals including the American Journal of Psychiatry, the Journal of Biological Rhythms, the International Journal of Endocrinology and Postpartum Equilibria: Journal of Postpartum Depression Research.


      Collapse Research 
      Collapse Research Activities and Funding
      Complementary Chronotherapeutics for Pregnancy and Postpartum Depression
      NIH/NICHD R01HD076476Jul 1, 2013 - Apr 30, 2018
      Role: Principal Investigator
      Alternative Treatments for Premenstrual Dysphoric Disorder
      NIH/NCCIH R01AT007169May 1, 2013 - Apr 30, 2018
      Role: Principal Investigator
      Melatonin in Menopausal Depression
      NIH/NIMH R01MH080159Dec 21, 2007 - Nov 30, 2012
      Role: Principal Investigator
      Biological Rhythms in Postpartum Depression
      NIH/NIMH R01MH070788Aug 19, 2005 - Jul 31, 2011
      Role: Principal Investigator
      Probing Premenstrual Dysphoric Disorder with Light
      NIH/NIMH R01MH063462Sep 19, 2002 - Jan 31, 2009
      Role: Principal Investigator
      MENOPAUSAL DEPRESSION: CHRONOBIOLOGIC BASIS
      NIH/NIMH R01MH059919Apr 1, 2000 - Mar 31, 2006
      Role: Principal Investigator
      CHRONOBIOLOGIC BASIS OF MOOD DISORDERS IN WOMEN
      NIH/NIMH R01MH051214Feb 15, 1996 - Jan 31, 2000
      Role: Principal Investigator
      CHRONOBIOLOGY OF PREMENSTRUAL SYNDROME
      NIH/NIMH R29MH042831Feb 15, 1989 - Jan 31, 1995
      Role: Principal Investigator
      General Clinical Research Center
      NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Co-Investigator

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Parry B. Beneficial effects of aging on mood in healthy postmenopausal women. Menopause. 2017 May; 24(5):475-477. PMID: 28225429.
        View in: PubMed
      2. Parry B. Spiritual Dimensions of Suicide Prevention. Am J Psychiatry. 2017 Apr 01; 174(4):398. PMID: 28366088.
        View in: PubMed
      3. Parry B. Somatic, more than affective, anxiety increases the risk for menopausal hot flashes. Menopause. 2016 Sep; 23(9):935-7. PMID: 27465712.
        View in: PubMed
      4. Parry B. Hormonal-stress interactions in precipitating perimenopausal depressive symptoms. Menopause. 2016 Mar; 23(3):236-8. PMID: 26886882.
        View in: PubMed
      5. Parry B. Rhythms and Blues. J Womens Health (Larchmt). 2016 Jun; 25(6):563-4. PMID: 26872087.
        View in: PubMed
      6. Meliska CJ, Martínez LF, López AM, Sorenson DL, Nowakowski S, Kripke DF, Elliott J, Parry B. Antepartum depression severity is increased during seasonally longer nights: relationship to melatonin and cortisol timing and quantity. Chronobiol Int. 2013 Nov; 30(9):1160-73. PMID: 23998286.
        View in: PubMed
      7. Parry B. To treat or not to treat perinatal depression with antidepressant medication: effects on infant growth. Am J Psychiatry. 2013 May 1; 170(5):453-4. PMID: 23511843.
        View in: PubMed
      8. Orff HJ, Meliska CJ, Lopez A, Martinez F, Sorenson D, Parry B. Polysomnographic evaluation of sleep quality and quantitative variables in women as a function of mood, reproductive status, and age. Dialogues Clin Neurosci. 2012 Dec; 14(4):413-24. PMID: 23393417.
        View in: PubMed
      9. Parry B, Meliska CJ, Sorenson DL, Martínez LF, López AM, Elliott JA, Hauger RL. Reduced phase-advance of plasma melatonin after bright morning light in the luteal, but not follicular, menstrual cycle phase in premenstrual dysphoric disorder: an extended study. Chronobiol Int. 2011 May; 28(5):415-24. PMID: 21721857.
        View in: PubMed
      10. Meliska CJ, Martínez LF, López AM, Sorenson DL, Nowakowski S, Parry B. Relationship of morningness-eveningness questionnaire score to melatonin and sleep timing, body mass index and atypical depressive symptoms in peri- and post-menopausal women. Psychiatry Res. 2011 Jun 30; 188(1):88-95. PMID: 21237517.
        View in: PubMed
      11. Parry B. Optimal management of perimenopausal depression. Int J Womens Health. 2010; 2:143-51. PMID: 21072307.
        View in: PubMed
      12. Parry B, Meliska CJ, Sorenson DL, Lopez A, Martínez LF, Hauger RL, Elliott JA. Increased sensitivity to light-induced melatonin suppression in premenstrual dysphoric disorder. Chronobiol Int. 2010 Aug; 27(7):1438-53. PMID: 20795885.
        View in: PubMed
      13. Kripke DF, Elliott JA, Youngstedt SD, Parry B, Hauger RL, Rex KM. Weak evidence of bright light effects on human LH and FSH. J Circadian Rhythms. 2010; 8:5. PMID: 20459826.
        View in: PubMed
      14. Parry B. Assessing risk and benefit: to treat or not to treat major depression during pregnancy with antidepressant medication. Am J Psychiatry. 2009 May; 166(5):512-4. PMID: 19411375.
        View in: PubMed
      15. Nowakowski S, Meliska CJ, Martinez LF, Parry B. Sleep and menopause. Curr Neurol Neurosci Rep. 2009 Mar; 9(2):165-72. PMID: 19268040.
        View in: PubMed
      16. Parry B, Meliska CJ, Sorenson DL, Lopez AM, Martinez LF, Nowakowski S, Elliott JA, Hauger RL, Kripke DF. Plasma melatonin circadian rhythm disturbances during pregnancy and postpartum in depressed women and women with personal or family histories of depression. Am J Psychiatry. 2008 Dec; 165(12):1551-8. PMID: 18829869.
        View in: PubMed
      17. Parry B, Meliska CJ, Martínez LF, López AM, Sorenson DL, Hauger RL, Elliott JA. Late, but not early, wake therapy reduces morning plasma melatonin: relationship to mood in Premenstrual Dysphoric Disorder. Psychiatry Res. 2008 Oct 30; 161(1):76-86. PMID: 18789826.
        View in: PubMed
      18. Parry B. Perimenopausal depression. Am J Psychiatry. 2008 Jan; 165(1):23-7. PMID: 18178752.
        View in: PubMed
      19. Parry B, Meliska CJ, Sorenson DL, López AM, Martínez LF, Nowakowski S, Hauger RL, Elliott JA. Increased melatonin and delayed offset in menopausal depression: role of years past menopause, follicle-stimulating hormone, sleep end time, and body mass index. J Clin Endocrinol Metab. 2008 Jan; 93(1):54-60. PMID: 18042653.
        View in: PubMed
      20. Parry B, Fernando Martínez L, Maurer EL, López AM, Sorenson D, Meliska CJ. Sleep, rhythms and women's mood. Part II. Menopause. Sleep Med Rev. 2006 Jun; 10(3):197-208. PMID: 16618548.
        View in: PubMed
      21. Parry B, Martínez LF, Maurer EL, López AM, Sorenson D, Meliska CJ. Sleep, rhythms and women's mood. Part I. Menstrual cycle, pregnancy and postpartum. Sleep Med Rev. 2006 Apr; 10(2):129-44. PMID: 16460973.
        View in: PubMed
      22. Srinivasan V, Smits M, Spence W, Lowe AD, Kayumov L, Pandi-Perumal SR, Parry B, Cardinali DP. Melatonin in mood disorders. World J Biol Psychiatry. 2006; 7(3):138-51. PMID: 16861139.
        View in: PubMed
      23. Gamst A, Wolfson T, Parry B. Local polynomial regression modeling of human plasma melatonin levels. J Biol Rhythms. 2004 Apr; 19(2):164-74. PMID: 15038856.
        View in: PubMed
      24. Parry B, Meliska CJ, Martinez LF, Basavaraj N, Zirpoli GG, Sorenson D, Maurer EL, Lopez A, Markova K, Gamst A, Wolfson T, Hauger R, Kripke DF. Menopause: neuroendocrine changes and hormone replacement therapy. J Am Med Womens Assoc. 2004; 59(2):135-45. PMID: 15134429.
        View in: PubMed
      25. Parry B, Maurer EL. Light treatment of mood disorders. Dialogues Clin Neurosci. 2003 Dec; 5(4):353-65. PMID: 22033495.
        View in: PubMed
      26. Westlund Tam L, Parry B. Does estrogen enhance the antidepressant effects of fluoxetine? J Affect Disord. 2003 Oct; 77(1):87-92. PMID: 14550939.
        View in: PubMed
      27. Parry B, Sorenson DL, Meliska CJ, Basavaraj N, Zirpoli GG, Gamst A, Hauger R. Hormonal basis of mood and postpartum disorders. Curr Womens Health Rep. 2003 Jun; 3(3):230-5. PMID: 12734034.
        View in: PubMed
      28. Wang EJ, Kripke DF, Stein MT, Parry B. Measurement of illumination exposure in postpartum women. BMC Psychiatry. 2003 May 13; 3:5. PMID: 12744724.
        View in: PubMed
      29. Parry B. Jet lag: minimizing it's effects with critically timed bright light and melatonin administration. J Mol Microbiol Biotechnol. 2002 Sep; 4(5):463-6. PMID: 12432956.
        View in: PubMed
      30. Mills PJ, Farag NH, Newton RP, Parry B. Effects of a traditional herbal supplement on anxiety in patients with generalized anxiety disorder. J Clin Psychopharmacol. 2002 Aug; 22(4):443-4. PMID: 12172353.
        View in: PubMed
      31. Farag NH, Nelesen RA, Parry B, Loredo JS, Dimsdale JE, Mills PJ. Autonomic and cardiovascular function in postmenopausal women: the effects of estrogen versus combination therapy. Am J Obstet Gynecol. 2002 May; 186(5):954-61. PMID: 12015521.
        View in: PubMed
      32. Parry B, Newton RP. Chronobiological basis of female-specific mood disorders. Neuropsychopharmacology. 2001 Nov; 25(5 Suppl):S102-8. PMID: 11682284.
        View in: PubMed
      33. Parry B. The role of central serotonergic dysfunction in the aetiology of premenstrual dysphoric disorder: therapeutic implications. CNS Drugs. 2001; 15(4):277-85. PMID: 11463133.
        View in: PubMed
      34. Parry B, Curran ML, Stuenkel CA, Yokimozo M, Tam L, Powell KA, Gillin JC. Can critically timed sleep deprivation be useful in pregnancy and postpartum depressions? J Affect Disord. 2000 Nov; 60(3):201-12. PMID: 11074109.
        View in: PubMed
      35. Parry B, Haynes P. Mood disorders and the reproductive cycle. J Gend Specif Med. 2000 Jul-Aug; 3(5):53-8. PMID: 11253256.
        View in: PubMed
      36. Parry B, Mostofi N, LeVeau B, Nahum HC, Golshan S, Laughlin GA, Gillin JC. Sleep EEG studies during early and late partial sleep deprivation in premenstrual dysphoric disorder and normal control subjects. Psychiatry Res. 1999 Feb 22; 85(2):127-43. PMID: 10220004.
        View in: PubMed
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