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    Antonio De Maio

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentSurgery
    Address9500 Gilman Drive #0739
    CA La Jolla 92093
    Phone858-822-6501
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Dr. Antonio De Maio is professor and a member of the Biomedical Sciences Graduate Program (BMS) at UC San Diego.

      A graduate of the Central University of Venezuela in Caracas, Dr. Antonio De Maio received his PhD from the Weizmann Institute of Science in Rehovot, Israel. Dr. Antonio De Maio joined the faculty at UC San Diego School of Medicine in January 2006.

      Prior to that, he was an Associate Professor and Research Director for the Division of Pediatric Surgery at Johns Hopkins University. While at Hopkins, Dr. De Maio led the Committee for the Recruitment of Under-represented Minorities to Graduate Programs and the Post-baccalaureate Research Education Program (PREP). At UC San Diego, Dr. De Maio continues to be very active in increasing student diversity in graduate and medical school.

      He received a Vice Chancellor of Health Sciences 2007 Equal Opportunity/Affirmative Action and Diversity Award. Dr. De Maio is the Director of the Initiative to Maximize Student Diversity (IMSD) Program at UC San Diego, which is supported by NIGMS-NIH.

      Dr. De Maio is a member of the American Association for the Advancement of Science (AAAS), American Society for Cell Biology (ASCB), American Association of Immunologist (AAI), Cell Stress Society International (President-Elect), International Endotoxin Society (IEIIS), PanAmerican Trauma Society, Shock Society, Society of Critical Care Medicine (SCCM), and Society for Advancement of Chicanos and Native Americans in Science (SACNAS).

      The Antonio De Maio Laboratory
      Located on UC San Diego's beautiful La Jolla campus, the Antonio De Maio laboratory is investigating the molecular and genetic bases of the response to injury. Traumatic injury is a major cause of mortality and morbidity in the United States, particularly among children.

      The Antonio De Maio laboratory has found that the response to injury is modulated by several confounding factors including genetic background, sex, age, diet, and environment. The major factor associated with morbidity and mortality injury is an overwhelming inflammatory response.

      The Antonio De Maio group is using mouse genetics to identify genes that regulate the inflammatory process as potential therapeutic targets. In addition, the Antonio De Maio laboratory is studying the role of heat shock proteins in the regulation of the inflammatory response.

      The Antonio De Maio Laboratory is actively engaged in the training of basic scientists, future academic surgeons and students at the undergraduate, graduate and medical school levels.

      The Antonio De Maio Laboratory is actively engaged in the training of basic scientists, future academic surgeons and students at the undergraduate, graduate and medical school levels. For more information on their research, please click here.


      Collapse Research 
      Collapse Research Activities and Funding
      Contribution of Cholesterol Homeostasis for Injury Resolution
      NIH/NIGMS R01GM114473Apr 1, 2015 - Dec 31, 2018
      Role: Principal Investigator
      Heat Shock Proteins and the Stress Observation System
      NIH/NIGMS R01GM098455Sep 1, 2012 - Apr 30, 2016
      Role: Principal Investigator
      UCSD MARC Program
      NIH/NIGMS T34GM087193Jun 1, 2009 - May 31, 2015
      Role: Principal Investigator
      Mentoring Young Minds to Increase Diversity in the Biomedical Research
      NIH/NIGMS R25GM083275Mar 1, 2008 - Mar 31, 2017
      Role: Principal Investigator
      Modifier genes of sepsis
      NIH/NIGMS R01GM073825Sep 1, 2006 - Aug 31, 2011
      Role: Principal Investigator
      GENETIC CONTRIBUTION TO THE STRESS RESPONSE
      NIH/NIGMS R01GM057317Jan 1, 1999 - Dec 31, 2004
      Role: Principal Investigator
      Mechanisms of cytoprotection induced by stress proteins
      NIH/NIGMS R01GM050878Aug 1, 1994 - Jul 31, 2010
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Rivera I, Capone R, Cauvi DM, Arispe N, De Maio A. Modulation of Alzheimer's amyloid ß peptide oligomerization and toxicity by extracellular Hsp70. Cell Stress Chaperones. 2017 Sep 27. PMID: 28956268.
        View in: PubMed
      2. Halbach J, Bickler S, De Maio A. The Molecular Complexity of Sepsis: Expression of Peroxisome Proliferator-Activated Receptor-a, the Tip of the Iceberg? Crit Care Med. 2016 Aug; 44(8):1617-8. PMID: 27428127.
        View in: PubMed
      3. Lopez V, Cauvi DM, Arispe N, De Maio A. Bacterial Hsp70 (DnaK) and mammalian Hsp70 interact differently with lipid membranes. Cell Stress Chaperones. 2016 07; 21(4):609-16. PMID: 27075190; PMCID: PMC4907991 [Available on 01/01/17].
      4. Williams MR, Cauvi DM, Rivera I, Hawisher D, De Maio A. Changes in macrophage function modulated by the lipid environment. Innate Immun. 2016 Apr; 22(3):141-51. PMID: 26951856.
        View in: PubMed
      5. Kao S, Shaterian A, Cauvi DM, Dang X, Chun HB, De Maio A, Costantini TW, Coimbra R, Eliceiri BP, Baird A. Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor gene ECRG4 in lung. Exp Lung Res. 2015 Apr; 41(3):162-72. PMID: 25513848; PMCID: PMC4524537.
      6. Bickler SW, Lizardo RE, De Maio A. The transition from a rural to an urban environment alters expression of the human Ebola virus receptor Neiman-Pick C1: implications for the current epidemic in West Africa. Cell Stress Chaperones. 2015 Mar; 20(2):203-6. PMID: 25477151; PMCID: PMC4326391.
      7. Vazquez DE, Niño DF, De Maio A, Cauvi DM. Sustained expression of lipocalin-2 during polymicrobial sepsis. Innate Immun. 2015 Jul; 21(5):477-89. PMID: 25227123.
        View in: PubMed
      8. Cauvi DM, Williams MR, Bermudez JA, Armijo G, De Maio A. Elevated expression of IL-23/IL-17 pathway-related mediators correlates with exacerbation of pulmonary inflammation during polymicrobial sepsis. Shock. 2014 Sep; 42(3):246-55. PMID: 24978886; PMCID: PMC4134380.
      9. Niño DF, Cauvi DM, De Maio A. Itraconazole, a commonly used antifungal, inhibits Fc? receptor-mediated phagocytosis: alteration of Fc? receptor glycosylation and gene expression. Shock. 2014 Jul; 42(1):52-9. PMID: 24667630; PMCID: PMC4071940.
      10. Armijo G, Okerblom J, Cauvi DM, Lopez V, Schlamadinger DE, Kim J, Arispe N, De Maio A. Interaction of heat shock protein 70 with membranes depends on the lipid environment. Cell Stress Chaperones. 2014 Nov; 19(6):877-86. PMID: 24789271; PMCID: PMC4389847.
      11. De Maio A. Extracellular Hsp70: export and function. Curr Protein Pept Sci. 2014 May; 15(3):225-31. PMID: 24694368.
        View in: PubMed
      12. De Maio A. What can we learn from elegant clinical studies?*. Crit Care Med. 2014 Apr; 42(4):972-3. PMID: 24633091; PMCID: PMC3960573.
      13. De Maio A, Vazquez D. Extracellular heat shock proteins: a new location, a new function. Shock. 2013 Oct; 40(4):239-46. PMID: 23807250; PMCID: PMC4351735.
      14. Cauvi DM, Song D, Vazquez DE, Hawisher D, Bermudez JA, Williams MR, Bickler S, Coimbra R, De Maio A. Period of irreversible therapeutic intervention during sepsis correlates with phase of innate immune dysfunction. J Biol Chem. 2012 Jun 08; 287(24):19804-15. PMID: 22518839; PMCID: PMC3370166.
      15. De Maio A, Santoro MG, Tanguay RM, Hightower LE. Ferruccio Ritossa's scientific legacy 50 years after his discovery of the heat shock response: a new view of biology, a new society, and a new journal. Cell Stress Chaperones. 2012 Mar; 17(2):139-43. PMID: 22252402; PMCID: PMC3273555.
      16. Bickler SW, Ring J, De Maio A. Sulfur amino acid metabolism limits the growth of children living in environments of poor sanitation. Med Hypotheses. 2011 Sep; 77(3):380-2. PMID: 21658846.
        View in: PubMed
      17. Drummond R, Song D, Hawisher D, Wolf PL, Vazquez DE, Nino DF, Coimbra R, Cauvi DM, De Maio A. Acute acalculous cholecystitis-like phenotype in scavenger receptor A knock-out mice. J Surg Res. 2012 May 15; 174(2):344-51. PMID: 21474146; PMCID: PMC3173564.
      18. De Maio A. Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa. Cell Stress Chaperones. 2011 May; 16(3):235-49. PMID: 20963644; PMCID: PMC3077223.
      19. De Maio A, Tanguay RM, Kampinga H, Lee E, Kim CD, Hightower L. Stress at the Korean Mountains: meeting report of the 8th International Workshop on the Molecular Biology of Stress Responses. Cell Stress Chaperones. 2011 Mar; 16(2):113-8. PMID: 20886326; PMCID: PMC3059799.
      20. Grabowski J, Vazquez DE, Costantini T, Cauvi DM, Charles W, Bickler S, Talamini MA, Vega VL, Coimbra R, De Maio A. Tumor necrosis factor expression is ameliorated after exposure to an acidic environment. J Surg Res. 2012 Mar; 173(1):127-34. PMID: 20888586; PMCID: PMC3017641.
      21. Vega VL, Charles W, De Maio A. A new feature of the stress response: increase in endocytosis mediated by Hsp70. Cell Stress Chaperones. 2010 Sep; 15(5):517-27. PMID: 20043217; PMCID: PMC3006637.
      22. Frey T, De Maio A. The antifungal agent itraconazole induces the accumulation of high mannose glycoproteins in macrophages. J Biol Chem. 2009 Jun 19; 284(25):16882-90. PMID: 19414590; PMCID: PMC2719324.
      23. Schilling D, Gehrmann M, Steinem C, De Maio A, Pockley AG, Abend M, Molls M, Multhoff G. Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells. FASEB J. 2009 Aug; 23(8):2467-77. PMID: 19289606; PMCID: PMC2717766.
      24. Vega VL, Rodríguez-Silva M, Frey T, Gehrmann M, Diaz JC, Steinem C, Multhoff G, Arispe N, De Maio A. Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J Immunol. 2008 Mar 15; 180(6):4299-307. PMID: 18322243.
        View in: PubMed
      25. Balakrishnan K, De Maio A. Heat shock protein 70 binds its own messenger ribonucleic acid as part of a gene expression self-limiting mechanism. Cell Stress Chaperones. 2006; 11(1):44-50. PMID: 16572728; PMCID: PMC1400612.
      26. Multhoff G, De Maio A. Stress down south: meeting report of the fifth International Workshop on the Molecular Biology of Stress Responses. Cell Stress Chaperones. 2006; 11(2):108-15. PMID: 16817316; PMCID: PMC1484512.
      27. Vega VL, De Maio A. Increase in phagocytosis after geldanamycin treatment or heat shock: role of heat shock proteins. J Immunol. 2005 Oct 15; 175(8):5280-7. PMID: 16210633.
        View in: PubMed
      28. Vega VL, De Maio A. Geldanamycin treatment ameliorates the response to LPS in murine macrophages by decreasing CD14 surface expression. Mol Biol Cell. 2003 Feb; 14(2):764-73. PMID: 12589068; PMCID: PMC150006.
      29. Arispe N, Doh M, De Maio A. Lipid interaction differentiates the constitutive and stress-induced heat shock proteins Hsc70 and Hsp70. Cell Stress Chaperones. 2002 Oct; 7(4):330-8. PMID: 12653477; PMCID: PMC514832.
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