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    Andrew Chisholm

    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0368
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Cytoskeletal dynamics in axon regeneration
      NIH/NINDS R01NS093588Jul 15, 2015 - Apr 30, 2019
      Role: Principal Investigator
      Development of a C. elegans model for axonal regeneration
      NIH/NINDS R01NS057317Jan 15, 2009 - Dec 31, 2014
      Role: Principal Investigator
      Development of a C.elegans model for axonal regeneration
      NIH/NINDS R56NS057317Dec 1, 2006 - Mar 31, 2015
      Role: Principal Investigator
      Santa Cruz Meetings on Developmental Biology
      NIH/NICHD R13HD048142Jul 1, 2004 - Jun 30, 2005
      Role: Principal Investigator
      Mechanisms of Tissue Morphogenesis in C. elegans
      NIH/NIGMS R01GM054657May 1, 1997 - Mar 31, 2019
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Knowlton WM, Hubert T, Wu Z, Chisholm A, Jin Y. A Select Subset of Electron Transport Chain Genes Associated with Optic Atrophy Link Mitochondria to Axon Regeneration in Caenorhabditis elegans. Front Neurosci. 2017; 11:263. PMID: 28539870.
        View in: PubMed
      2. Chen F, Chisholm A, Jin Y. Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform in C. elegans epidermal development. Development. 2017 Feb 15; 144(4):698-707. PMID: 28087624.
        View in: PubMed
      3. Chisholm A, Hutter H, Jin Y, Wadsworth WG. The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans. Genetics. 2016 Nov; 204(3):849-882. PMID: 28114100.
        View in: PubMed
      4. Chuang M, Hsiao TI, Tong A, Xu S, Chisholm A. DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair. Elife. 2016 Sep 23; 5. PMID: 27661253.
        View in: PubMed
      5. Chen L, Liu Z, Zhou B, Wei C, Zhou Y, Rosenfeld MG, Fu XD, Chisholm A, Jin Y. CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins. Elife. 2016 Jun 02; 5. PMID: 27253061; PMCID: PMC4946901.
      6. Tang NH, Chisholm A. Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans. F1000Res. 2016; 5. PMID: 27350865; PMCID: PMC4892358.
      7. Xu S, Chisholm A. Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG. Sci Rep. 2016 Feb 10; 6:21271. PMID: 26861262; PMCID: PMC4748272.
      8. Xu S, Wang Z, Kim KW, Jin Y, Chisholm A. Targeted Mutagenesis of Duplicated Genes in Caenorhabditis elegans Using CRISPR-Cas9. J Genet Genomics. 2016 Feb 20; 43(2):103-6. PMID: 26924693.
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      9. Venkatachalam V, Ji N, Wang X, Clark C, Mitchell JK, Klein M, Tabone CJ, Florman J, Ji H, Greenwood J, Chisholm A, Srinivasan J, Alkema M, Zhen M, Samuel AD. Pan-neuronal imaging in roaming Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):E1082-8. PMID: 26711989; PMCID: PMC4776525.
      10. Schwieterman AA, Steves AN, Yee V, Donelson CJ, Bentley MR, Santorella EM, Mehlenbacher TV, Pital A, Howard AM, Wilson MR, Ereddia DE, Effrein KS, McMurry JL, Ackley BD, Chisholm A, Hudson ML. The Caenorhabditis elegans Ephrin EFN-4 Functions Non-cell Autonomously with Heparan Sulfate Proteoglycans to Promote Axon Outgrowth and Branching. Genetics. 2016 Feb; 202(2):639-60. PMID: 26645816; PMCID: PMC4788240 [Available on 02/01/17].
      11. Chen L, Chuang M, Koorman T, Boxem M, Jin Y, Chisholm A. Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase. Elife. 2015 Sep 04; 4. PMID: 26339988; PMCID: PMC4596636.
      12. Chisholm A. Epidermal Wound Healing in the Nematode Caenorhabditis elegans. Adv Wound Care (New Rochelle). 2015 Apr 01; 4(4):264-271. PMID: 25945288.
        View in: PubMed
      13. Loer CM, Calvo AC, Watschinger K, Werner-Felmayer G, O'Rourke D, Stroud D, Tong A, Gotenstein JR, Chisholm A, Hodgkin J, Werner ER, Martinez A. Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4). Genetics. 2015 May; 200(1):237-53. PMID: 25808955; PMCID: PMC4423366.
      14. Liu J, Chuang M, Chisholm A, Cosman P. Image registration robust to sparse large errors. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:1975-80. PMID: 26736672.
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      15. Chisholm A. Deep reads: strands in the history of molecular genetics. PLoS Genet. 2014 Dec; 10(12):e1004887. PMID: 25521096; PMCID: PMC4270799.
      16. Xu S, Chisholm A. Methods for skin wounding and assays for wound responses in C. elegans. J Vis Exp. 2014 Dec 03; (94). PMID: 25548955; PMCID: PMC4396949.
      17. Chuang M, Goncharov A, Wang S, Oegema K, Jin Y, Chisholm A. The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans. Cell Rep. 2014 Nov 06; 9(3):874-83. PMID: 25437544; PMCID: PMC4250830.
      18. Xu S, Chisholm A. C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair. Dev Cell. 2014 Oct 13; 31(1):48-60. PMID: 25313960; PMCID: PMC4197410.
      19. Kang S, Lee CY, Gonçalves M, Chisholm A, Cosman PC. Tracking epithelial cell junctions in C. elegans embryogenesis with active contours guided by SIFT flow. IEEE Trans Biomed Eng. 2015 Apr; 62(4):1020-33. PMID: 24771564; PMCID: PMC4418224.
      20. Chuang M, Chisholm A. Insights into the functions of the death associated protein kinases from C. elegans and other invertebrates. Apoptosis. 2014 Feb; 19(2):392-7. PMID: 24242918; PMCID: PMC3947127.
      21. Hubert T, Wu Z, Chisholm A, Jin Y. S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans. J Neurosci. 2014 Jan 15; 34(3):758-63. PMID: 24431434; PMCID: PMC3891956.
      22. Wang Z, Hou Y, Guo X, van der Voet M, Boxem M, Dixon JE, Chisholm A, Jin Y. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Neuron. 2013 Sep 04; 79(5):903-16. PMID: 24012004; PMCID: PMC3779136.
      23. Grossman EN, Giurumescu CA, Chisholm A. Mechanisms of ephrin receptor protein kinase-independent signaling in amphid axon guidance in Caenorhabditis elegans. Genetics. 2013 Nov; 195(3):899-913. PMID: 23979582; PMCID: PMC3813872.
      24. Chisholm A. Cytoskeletal dynamics in Caenorhabditis elegans axon regeneration. Annu Rev Cell Dev Biol. 2013; 29:271-97. PMID: 23844582.
        View in: PubMed
      25. Giurumescu CA, Kang S, Planchon TA, Betzig E, Bloomekatz J, Yelon D, Cosman P, Chisholm A. Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos. Development. 2012 Nov; 139(22):4271-9. PMID: 23052905; PMCID: PMC3478691.
      26. Ghosh-Roy A, Goncharov A, Jin Y, Chisholm A. Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration. Dev Cell. 2012 Oct 16; 23(4):716-28. PMID: 23000142; PMCID: PMC3477258.
      27. Chisholm A, Hsiao TI. The Caenorhabditis elegans epidermis as a model skin. I: development, patterning, and growth. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; 1(6):861-78. PMID: 23539299; PMCID: PMC3607643.
      28. Chisholm A, Xu S. The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; 1(6):879-902. PMID: 23539358; PMCID: PMC3607645.
      29. Xu S, Hsiao TI, Chisholm A. The wounded worm: Using C. elegans to understand the molecular basis of skin wound healing. Worm. 2012 Apr 01; 1(2):134-8. PMID: 24058838; PMCID: PMC3670230.
      30. Xu S, Chisholm A. A Gaq-Ca²? signaling pathway promotes actin-mediated epidermal wound closure in C. elegans. Curr Biol. 2011 Dec 06; 21(23):1960-7. PMID: 22100061; PMCID: PMC3237753.
      31. Chen L, Wang Z, Ghosh-Roy A, Hubert T, Yan D, O'Rourke S, Bowerman B, Wu Z, Jin Y, Chisholm A. Axon regeneration pathways identified by systematic genetic screening in C. elegans. Neuron. 2011 Sep 22; 71(6):1043-57. PMID: 21943602; PMCID: PMC3183436.
      32. Chen L, Chisholm A. Axon regeneration mechanisms: insights from C. elegans. Trends Cell Biol. 2011 Oct; 21(10):577-84. PMID: 21907582; PMCID: PMC3183269.
      33. Giurumescu CA, Chisholm A. Cell identification and cell lineage analysis. Methods Cell Biol. 2011; 106:325-41. PMID: 22118283; PMCID: PMC4410678.
      34. Gotenstein JR, Swale RE, Fukuda T, Wu Z, Giurumescu CA, Goncharov A, Jin Y, Chisholm A. The C. elegans peroxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration. Development. 2010 Nov; 137(21):3603-13. PMID: 20876652; PMCID: PMC2964093.
      35. Fakhouri TH, Stevenson J, Chisholm A, Mango SE. Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA. PLoS Genet. 2010 Aug 12; 6(8). PMID: 20714352; PMCID: PMC2920861.
      36. Ghosh-Roy A, Chisholm A. Caenorhabditis elegans: a new model organism for studies of axon regeneration. Dev Dyn. 2010 May; 239(5):1460-4. PMID: 20186917; PMCID: PMC3069807.
      37. Ghosh-Roy A, Wu Z, Goncharov A, Jin Y, Chisholm A. Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase. J Neurosci. 2010 Mar 03; 30(9):3175-83. PMID: 20203177; PMCID: PMC2921707.
      38. Kaminsky R, Denison C, Bening-Abu-Shach U, Chisholm A, Gygi SP, Broday L. SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegans. Dev Cell. 2009 Nov; 17(5):724-35. PMID: 19922876; PMCID: PMC2803632.
      39. Yan D, Wu Z, Chisholm A, Jin Y. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell. 2009 Sep 04; 138(5):1005-18. PMID: 19737525; PMCID: PMC2772821.
      40. Tong A, Lynn G, Ngo V, Wong D, Moseley SL, Ewbank JJ, Goncharov A, Wu YC, Pujol N, Chisholm A. Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1457-61. PMID: 19164535; PMCID: PMC2629440.
      41. Ding M, King RS, Berry EC, Wang Y, Hardin J, Chisholm A. The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PLoS One. 2008 Oct 03; 3(10):e3346. PMID: 18833327; PMCID: PMC2553197.
      42. Woo WM, Berry EC, Hudson ML, Swale RE, Goncharov A, Chisholm A. The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues. Development. 2008 Aug; 135(16):2747-56. PMID: 18614580.
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      43. Chisholm A. Semaphorin signaling in morphogenesis: found in translation. Genes Dev. 2008 Apr 15; 22(8):955-9. PMID: 18413708; PMCID: PMC2732391.
      44. Pujol N, Cypowyj S, Ziegler K, Millet A, Astrain A, Goncharov A, Jin Y, Chisholm A, Ewbank JJ. Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr Biol. 2008 Apr 08; 18(7):481-9. PMID: 18394898; PMCID: PMC2394561.
      45. Wu Z, Ghosh-Roy A, Yanik MF, Zhang JZ, Jin Y, Chisholm A. Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15132-7. PMID: 17848506; PMCID: PMC1975853.
      46. Nakao F, Hudson ML, Suzuki M, Peckler Z, Kurokawa R, Liu Z, Gengyo-Ando K, Nukazuka A, Fujii T, Suto F, Shibata Y, Shioi G, Fujisawa H, Mitani S, Chisholm A, Takagi S. The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. Genetics. 2007 Jul; 176(3):1591-607. PMID: 17507686; PMCID: PMC1931547.
      47. Chisholm A. Gastrulation: Wnts signal constriction. Curr Biol. 2006 Oct 24; 16(20):R874-6. PMID: 17055968.
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      48. Nicot AS, Fares H, Payrastre B, Chisholm A, Labouesse M, Laporte J. The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans. Mol Biol Cell. 2006 Jul; 17(7):3062-74. PMID: 16801682; PMCID: PMC1483040.
      49. Hudson ML, Kinnunen T, Cinar HN, Chisholm A. C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations. Dev Biol. 2006 Jun 15; 294(2):352-65. PMID: 16677626.
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      50. Chisholm A, Hardin J. Epidermal morphogenesis. WormBook. 2005 Dec 01; 1-22. PMID: 18050408; PMCID: PMC4781537.
      51. Chisholm A, Jin Y. Neuronal differentiation in C. elegans. Curr Opin Cell Biol. 2005 Dec; 17(6):682-9. PMID: 16242313.
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      52. Furuya M, Qadota H, Chisholm A, Sugimoto A. The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6. Dev Biol. 2005 Oct 15; 286(2):452-63. PMID: 16154558.
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      53. Ackley BD, Harrington RJ, Hudson ML, Williams L, Kenyon CJ, Chisholm A, Jin Y. The two isoforms of the Caenorhabditis elegans leukocyte-common antigen related receptor tyrosine phosphatase PTP-3 function independently in axon guidance and synapse formation. J Neurosci. 2005 Aug 17; 25(33):7517-28. PMID: 16107639.
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      54. Nakata K, Abrams B, Grill B, Goncharov A, Huang X, Chisholm A, Jin Y. Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell. 2005 Feb 11; 120(3):407-20. PMID: 15707898.
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      55. Yanik MF, Cinar H, Cinar HN, Chisholm A, Jin Y, Ben-Yakar A. Neurosurgery: functional regeneration after laser axotomy. Nature. 2004 Dec 16; 432(7019):822. PMID: 15602545.
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      56. Ding M, Woo WM, Chisholm A. The cytoskeleton and epidermal morphogenesis in C. elegans. Exp Cell Res. 2004 Nov 15; 301(1):84-90. PMID: 15501449.
        View in: PubMed
      57. Cinar HN, Chisholm A. Genetic analysis of the Caenorhabditis elegans pax-6 locus: roles of paired domain-containing and nonpaired domain-containing isoforms. Genetics. 2004 Nov; 168(3):1307-22. PMID: 15579687; PMCID: PMC1448762.
      58. Zahler AM, Tuttle JD, Chisholm A. Genetic suppression of intronic +1G mutations by compensatory U1 snRNA changes in Caenorhabditis elegans. Genetics. 2004 Aug; 167(4):1689-96. PMID: 15342508; PMCID: PMC1471001.
      59. Woo WM, Goncharov A, Jin Y, Chisholm A. Intermediate filaments are required for C. elegans epidermal elongation. Dev Biol. 2004 Mar 01; 267(1):216-29. PMID: 14975728.
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      60. Ding M, Goncharov A, Jin Y, Chisholm A. C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Development. 2003 Dec; 130(23):5791-801. PMID: 14534136.
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      61. Huang CC, Hall DH, Hedgecock EM, Kao G, Karantza V, Vogel BE, Hutter H, Chisholm A, Yurchenco PD, Wadsworth WG. Laminin alpha subunits and their role in C. elegans development. Development. 2003 Jul; 130(14):3343-58. PMID: 12783803.
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      62. Bosher JM, Hahn BS, Legouis R, Sookhareea S, Weimer RM, Gansmuller A, Chisholm A, Rose AM, Bessereau JL, Labouesse M. The Caenorhabditis elegans vab-10 spectraplakin isoforms protect the epidermis against internal and external forces. J Cell Biol. 2003 May 26; 161(4):757-68. PMID: 12756232; PMCID: PMC2199363.
      63. Chin-Sang ID, Moseley SL, Ding M, Harrington RJ, George SE, Chisholm A. The divergent C. elegans ephrin EFN-4 functions inembryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor. Development. 2002 Dec; 129(23):5499-510. PMID: 12403719.
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      64. Harrington RJ, Gutch MJ, Hengartner MO, Tonks NK, Chisholm A. The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis. Development. 2002 May; 129(9):2141-53. PMID: 11959824.
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      65. Chin-Sang ID, Chisholm A. Form of the worm: genetics of epidermal morphogenesis in C. elegans. Trends Genet. 2000 Dec; 16(12):544-51. PMID: 11102704.
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      66. Chin-Sang ID, George SE, Ding M, Moseley SL, Lynch AS, Chisholm A. The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans. Cell. 1999 Dec 23; 99(7):781-90. PMID: 10619431.
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      67. Chisholm A, Tessier-Lavigne M. Conservation and divergence of axon guidance mechanisms. Curr Opin Neurobiol. 1999 Oct; 9(5):603-15. PMID: 10508749.
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      68. Dal Santo P, Logan MA, Chisholm A, Jorgensen EM. The inositol trisphosphate receptor regulates a 50-second behavioral rhythm in C. elegans. Cell. 1999 Sep 17; 98(6):757-67. PMID: 10499793.
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      69. Zhang Y, Ferreira HB, Greenstein D, Chisholm A, Emmons SW. Regulated nuclear entry of the C. elegans Pax-6 transcription factor. Mech Dev. 1998 Nov; 78(1-2):179-87. PMID: 9858725.
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      70. George SE, Simokat K, Hardin J, Chisholm A. The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. Cell. 1998 Mar 06; 92(5):633-43. PMID: 9506518.
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      71. Chisholm A, Horvitz HR. Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3. Nature. 1995 Sep 07; 377(6544):52-5. PMID: 7659159.
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      72. Wang BB, Müller-Immergluck MM, Austin J, Robinson NT, Chisholm A, Kenyon C. A homeotic gene cluster patterns the anteroposterior body axis of C. elegans. Cell. 1993 Jul 16; 74(1):29-42. PMID: 8101474.
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      73. Clark SG, Chisholm A, Horvitz HR. Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39. Cell. 1993 Jul 16; 74(1):43-55. PMID: 8101475.
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      74. Chisholm A. Control of cell fate in the tail region of C. elegans by the gene egl-5. Development. 1991 Apr; 111(4):921-32. PMID: 1879361.
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      75. Chisholm A, Hodgkin J. The mab-9 gene controls the fate of B, the major male-specific blast cell in the tail region of Caenorhabditis elegans. Genes Dev. 1989 Sep; 3(9):1413-23. PMID: 2606353.
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