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    Andres Leschziner

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0694
    CA La Jolla 92093
    Phone858-246-1252
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      Collapse Research 
      Collapse Research Activities and Funding
      West/Midwest Consortium for High-Resolution Cryo Electron Microscopy
      NIH/NIGMS U24GM116792Jul 11, 2016 - Jun 30, 2021
      Role: Principal Investigator
      Regulation of Cytoplasmic Dynein
      NIH/NIGMS R01GM107214Jun 10, 2014 - Feb 28, 2018
      Role: Principal Investigator
      A comparative structural study of ATP-dependent chromatin remodeling complexes
      NIH/NIGMS R01GM092895Apr 1, 2011 - Mar 31, 2016
      Role: Principal Investigator
      National Resource for Automated Molecular Microscopy
      NIH P41RR017573Sep 30, 2002 - Jul 31, 2012
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. DeSantis ME, Cianfrocco MA, Htet ZM, Tran PT, Reck-Peterson SL, Leschziner A. Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 2017 Sep 07; 170(6):1197-1208.e12. PMID: 28886386.
        View in: PubMed
      2. Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner A, Dixon JE, Xiao J. Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. Elife. 2017 Apr 22; 6. PMID: 28432788.
        View in: PubMed
      3. Cianfrocco MA, DeSantis ME, Leschziner A, Reck-Peterson SL. Mechanism and regulation of cytoplasmic dynein. Annu Rev Cell Dev Biol. 2015; 31:83-108. PMID: 26436706; PMCID: PMC4644480 [Available on 11/13/16].
      4. Cianfrocco MA, Leschziner A. Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud. Elife. 2015 May 08; 4. PMID: 25955969; PMCID: PMC4440898.
      5. Toropova K, Zou S, Roberts AJ, Redwine WB, Goodman BS, Reck-Peterson SL, Leschziner A. Lis1 regulates dynein by sterically blocking its mechanochemical cycle. Elife. 2014 Nov 07; 3. PMID: 25380312; PMCID: PMC4359366.
      6. Cianfrocco MA, Leschziner A. Traffic control: adaptor proteins guide dynein-cargo takeoff. EMBO J. 2014 Sep 01; 33(17):1845-6. PMID: 25061224; PMCID: PMC4195778.
      7. Nguyen VQ, Ranjan A, Stengel F, Wei D, Aebersold R, Wu C, Leschziner A. Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1. Cell. 2013 Sep 12; 154(6):1220-31. PMID: 24034246; PMCID: PMC3776929.
      8. Derr ND, Goodman BS, Jungmann R, Leschziner A, Shih WM, Reck-Peterson SL. Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science. 2012 Nov 02; 338(6107):662-5. PMID: 23065903; PMCID: PMC3840815.
      9. Huang J, Roberts AJ, Leschziner A, Reck-Peterson SL. Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell. 2012 Aug 31; 150(5):975-86. PMID: 22939623; PMCID: PMC3438448.
      10. Leschziner A. Electron microscopy studies of nucleosome remodelers. Curr Opin Struct Biol. 2011 Dec; 21(6):709-18. PMID: 22040801; PMCID: PMC3241934.
      11. Chandramouli P, Hernandez-Lopez R, Wang HW, Leschziner A. Validation of the orthogonal tilt reconstruction method with a biological test sample. J Struct Biol. 2011 Jul; 175(1):85-96. PMID: 21536134.
        View in: PubMed
      12. Norville JE, Derda R, Gupta S, Drinkwater KA, Belcher AM, Leschziner A, Knight TF. Introduction of customized inserts for s-treamlined assembly and optimization of BioBrick synthetic genetic circuits. J Biol Eng. 2010 Dec 20; 4:17. PMID: 21172029; PMCID: PMC3022552.
      13. Leschziner A. The orthogonal tilt reconstruction method. Methods Enzymol. 2010; 482:237-62. PMID: 20888964.
        View in: PubMed
      14. Bleichert F, Gagnon KT, Brown BA, Maxwell ES, Leschziner A, Unger VM, Baserga SJ. A dimeric structure for archaeal box C/D small ribonucleoproteins. Science. 2009 Sep 11; 325(5946):1384-7. PMID: 19745151; PMCID: PMC2975540.
      15. Wang HW, Ramey VH, Westermann S, Leschziner A, Welburn JP, Nakajima Y, Drubin DG, Barnes G, Nogales E. Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nat Struct Mol Biol. 2007 Aug; 14(8):721-6. PMID: 17643123.
        View in: PubMed
      16. Leschziner A, Saha A, Wittmeyer J, Zhang Y, Bustamante C, Cairns BR, Nogales E. Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):4913-8. PMID: 17360331; PMCID: PMC1820885.
      17. Leschziner A, Nogales E. Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions. Annu Rev Biophys Biomol Struct. 2007; 36:43-62. PMID: 17201674.
        View in: PubMed
      18. Clarey MG, Erzberger JP, Grob P, Leschziner A, Berger JM, Nogales E, Botchan M. Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol. 2006 Aug; 13(8):684-90. PMID: 16829958.
        View in: PubMed
      19. Leschziner A, Nogales E. The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles. J Struct Biol. 2006 Mar; 153(3):284-99. PMID: 16431136.
        View in: PubMed
      20. Leschziner A, Lemon B, Tjian R, Nogales E. Structural studies of the human PBAF chromatin-remodeling complex. Structure. 2005 Feb; 13(2):267-75. PMID: 15698570.
        View in: PubMed
      21. Leschziner A, Grindley ND. The architecture of the gammadelta resolvase crossover site synaptic complex revealed by using constrained DNA substrates. Mol Cell. 2003 Sep; 12(3):775-81. PMID: 14527421.
        View in: PubMed
      22. Sarkis GJ, Murley LL, Leschziner A, Boocock MR, Stark WM, Grindley ND. A model for the gamma delta resolvase synaptic complex. Mol Cell. 2001 Sep; 8(3):623-31. PMID: 11583624.
        View in: PubMed
      23. Xu Y, Potapova O, Leschziner A, Grindley ND, Joyce CM. Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate. J Biol Chem. 2001 Aug 10; 276(32):30167-77. PMID: 11349126.
        View in: PubMed
      24. Leschziner A, Moukhles H, Lindenbaum M, Gee SH, Butterworth J, Campbell KP, Carbonetto S. Neural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscle. J Neurochem. 2000 Jan; 74(1):70-80. PMID: 10617107.
        View in: PubMed
      25. Griffin TJ, Parsons L, Leschziner A, DeVost J, Derbyshire KM, Grindley ND. In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis. Nucleic Acids Res. 1999 Oct 01; 27(19):3859-65. PMID: 10481025; PMCID: PMC148649.
      26. Leschziner A, Griffin TJ, Grindley ND. Tn552 transposase catalyzes concerted strand transfer in vitro. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7345-50. PMID: 9636151; PMCID: PMC22612.
      27. Grindley ND, Leschziner A. DNA transposition: from a black box to a color monitor. Cell. 1995 Dec 29; 83(7):1063-6. PMID: 8548793.
        View in: PubMed
      28. Leschziner A, Boocock MR, Grindley ND. The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions. Mol Microbiol. 1995 Mar; 15(5):865-70. PMID: 7596288.
        View in: PubMed