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    Amy Tsai

    TitleResearcher
    SchoolUniversity of California, San Diego
    DepartmentBioengineering
    Address9500 Gilman Drive #0412
    CA La Jolla 92093
    Phone858-534-5847
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Plasma hyperviscosity for the reversal of hypovolemic cardiovascular collapse
      NIH/NHLBI R01HL076182Jan 1, 2004 - Dec 31, 2008
      Role: Principal Investigator
      CRITICAL MICROVASCULAR OXYGEN FLUCTUATIONS
      NIH/NHLBI F32HL008343Dec 24, 1990
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zimmerman R, Tsai A, Salazar Vázquez BY, Cabrales P, Hofmann A, Meier J, Shander A, Spahn DR, Friedman JM, Tartakovsky DM, Intaglietta M. Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity. Anesth Analg. 2017 May; 124(5):1547-1554. PMID: 28328758.
        View in: PubMed
      2. Martucci AF, Abreu Martucci AC, Cabrales P, Nascimento PD, Intaglietta M, Tsai A, Castiglia YM. Acute kidney function and morphology following topload administration of recombinant hemoglobin solution. Artif Cells Nanomed Biotechnol. 2017 Feb; 45(1):24-30. PMID: 27797281.
        View in: PubMed
      3. Tsai A, Vázquez BY, Hofmann A, Acharya SA, Intaglietta M. Supra-plasma expanders: the future of treating blood loss and anemia without red cell transfusions? J Infus Nurs. 2015 May-Jun; 38(3):217-22. PMID: 25871869.
        View in: PubMed
      4. Mooij HL, Cabrales P, Bernelot Moens SJ, Xu D, Udayappan SD, Tsai A, van der Sande MA, de Groot E, Intaglietta M, Kastelein JJ, Dallinga-Thie GM, Esko JD, Stroes ES, Nieuwdorp M. Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function. J Am Heart Assoc. 2014 Dec 02; 3(6):e001274. PMID: 25468659; PMCID: PMC4338717.
      5. Tsai A, Salazar Vázquez BY, Cabrales P, Kistler EB, Tartakovsky DM, Subramaniam S, Acharya SA, Intaglietta M. Replacing the Transfusion of 1-2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies. J Funct Biomater. 2014 Oct 27; 5(4):232-45. PMID: 25350267; PMCID: PMC4285404.
      6. Tsai A, Cabrales P, Young MA, Winslow RM, Intaglietta M. Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and functional capillary density in the transgenic mouse model of sickle cell anemia. Artif Cells Nanomed Biotechnol. 2015 Feb; 43(1):10-7. PMID: 25060721.
        View in: PubMed
      7. Meng F, Tsai A, Intaglietta M, Acharya SA. PEGylation of aa-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG aa-Hbs. Artif Cells Nanomed Biotechnol. 2015; 43(4):270-81. PMID: 24597567; PMCID: PMC4167218.
      8. Martini J, Cabrales P, Fries D, Intaglietta M, Tsai A. Effects of fibrinogen concentrate after shock/resuscitation: a comparison between in vivo microvascular clot formation and thromboelastometry*. Crit Care Med. 2013 Nov; 41(11):e301-8. PMID: 23978812; PMCID: PMC4109711.
      9. McQueen FM, Doyle A, Reeves Q, Gao A, Tsai A, Gamble GD, Curteis B, Williams M, Dalbeth N. Bone erosions in patients with chronic gouty arthropathy are associated with tophi but not bone oedema or synovitis: new insights from a 3 T MRI study. Rheumatology (Oxford). 2014 Jan; 53(1):95-103. PMID: 24080252.
        View in: PubMed
      10. Wadden TA, Volger S, Tsai A, Sarwer DB, Berkowitz RI, Diewald LK, Carvajal R, Moran CH, Vetter M. Managing obesity in primary care practice: an overview with perspective from the POWER-UP study. Int J Obes (Lond). 2013 Aug; 37 Suppl 1:S3-11. PMID: 23921779; PMCID: PMC3786742.
      11. Yalcin O, Ortiz D, Tsai A, Johnson PC, Cabrales P. Microhemodynamic aberrations created by transfusion of stored blood. Transfusion. 2014 Apr; 54(4):1015-27. PMID: 23901933; PMCID: PMC4105299.
      12. Tsai A, Intaglietta M, Sakai H, Delpy E, La Rochelle CD, Rousselot M, Zal F. Microcirculation and NO-CO studies of a natural extracellular hemoglobin developed for an oxygen therapeutic carrier. Curr Drug Discov Technol. 2012 Sep; 9(3):166-72. PMID: 22564165.
        View in: PubMed
      13. Sriram K, Salazar Vázquez BY, Tsai A, Cabrales P, Intaglietta M, Tartakovsky DM. Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit. Am J Physiol Heart Circ Physiol. 2012 Nov 01; 303(9):H1096-106. PMID: 22923620; PMCID: PMC3517642.
      14. Landsverk SA, Tsai A, Cabrales P, Intaglietta M. Impact of enzymatic degradation of the endothelial glycocalyx on vascular permeability in an awake hamster model. Crit Care Res Pract. 2012; 2012:842545. PMID: 22792450; PMCID: PMC3389652.
      15. Hightower CM, Salazar Vázquez BY, Cabrales P, Tsai A, Acharya SA, Intaglietta M. Plasma expander and blood storage effects on capillary perfusion in transfusion after hemorrhage. Transfusion. 2013 Jan; 53(1):49-59. PMID: 22554380; PMCID: PMC4517570.
      16. Sriram K, Tsai A, Cabrales P, Meng F, Acharya SA, Tartakovsky DM, Intaglietta M. PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning. Am J Physiol Heart Circ Physiol. 2012 Jun 15; 302(12):H2489-97. PMID: 22505638; PMCID: PMC3378262.
      17. Villela NR, Tsai A, Cabrales P, Intaglietta M. Improved resuscitation from hemorrhagic shock with Ringer's lactate with increased viscosity in the hamster window chamber model. J Trauma. 2011 Aug; 71(2):418-24. PMID: 21248647.
        View in: PubMed
      18. Vázquez BY, Hightower CM, Martini J, Messmer C, Frienesenecker B, Corbels P, Tsai A, Intaglietta M. Vasoactive hemoglobin solution improves survival in hemodilution followed by hemorrhagic shock. Crit Care Med. 2011 Jun; 39(6):1461-6. PMID: 21336111; PMCID: PMC3318980.
      19. Hightower CM, Salazar Vázquez BY, Woo Park S, Sriram K, Martini J, Yalcin O, Tsai A, Cabrales P, Tartakovsky DM, Johnson PC, Intaglietta M. Integration of cardiovascular regulation by the blood/endothelium cell-free layer. Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug; 3(4):458-70. PMID: 21523919.
        View in: PubMed
      20. Salazar Vázquez BY, Cabrales P, Tsai A, Intaglietta M. Nonlinear cardiovascular regulation consequent to changes in blood viscosity. Clin Hemorheol Microcirc. 2011; 49(1-4):29-36. PMID: 22214675.
        View in: PubMed
      21. Vázquez BY, Martini J, Tsai A, Johnson PC, Cabrales P, Intaglietta M. The variability of blood pressure due to small changes of hematocrit. Am J Physiol Heart Circ Physiol. 2010 Sep; 299(3):H863-7. PMID: 20601464; PMCID: PMC2944491.
      22. Tsai A, Hofmann A, Cabrales P, Intaglietta M. Perfusion vs. oxygen delivery in transfusion with "fresh" and "old" red blood cells: the experimental evidence. Transfus Apher Sci. 2010 Aug; 43(1):69-78. PMID: 20646963; PMCID: PMC2918661.
      23. Tsai A, Cabrales P, Intaglietta M. The physics of oxygen delivery: facts and controversies. Antioxid Redox Signal. 2010 Mar 15; 12(6):683-91. PMID: 19757988; PMCID: PMC2834451.
      24. Buehler PW, Zhou Y, Cabrales P, Jia Y, Sun G, Harris DR, Tsai A, Intaglietta M, Palmer AF. Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins. Biomaterials. 2010 May; 31(13):3723-35. PMID: 20149433; PMCID: PMC2837140.
      25. Salazar Vázquez BY, Martini J, Chávez Negrete A, Tsai A, Forconi S, Cabrales P, Johnson PC, Intaglietta M. Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence. Clin Hemorheol Microcirc. 2010; 44(2):75-85. PMID: 20203362.
        View in: PubMed
      26. Cabrales P, Sun G, Zhou Y, Harris DR, Tsai A, Intaglietta M, Palmer AF. Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction. J Appl Physiol (1985). 2009 Nov; 107(5):1548-58. PMID: 19745190; PMCID: PMC2777796.
      27. Cabrales P, Tsai A. Will fixing the vasoactivity caused by hemoglobin-based oxygen carriers be enough? Crit Care Med. 2009 Jun; 37(6):2125-6. PMID: 19448469.
        View in: PubMed
      28. Meng F, Manjula BN, Tsai A, Cabrales P, Intaglietta M, Smith PK, Prabhakaran M, Acharya SA. Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts. Protein J. 2009 Jun; 28(5):199-212. PMID: 19653083.
        View in: PubMed
      29. Villela NR, Cabrales P, Tsai A, Intaglietta M. Microcirculatory effects of changing blood hemoglobin oxygen affinity during hemorrhagic shock resuscitation in an experimental model. Shock. 2009 Jun; 31(6):645-52. PMID: 18948853.
        View in: PubMed
      30. Cabrales P, Tsai A, Intaglietta M. Exogenous nitric oxide induces protection during hemorrhagic shock. Resuscitation. 2009 Jun; 80(6):707-12. PMID: 19362408; PMCID: PMC2747810.
      31. Cabrales P, Tsai A, Intaglietta M. Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters. Shock. 2009 Mar; 31(3):300-7. PMID: 18636045.
        View in: PubMed
      32. Salazar Vázquez BY, Martini J, Chávez Negrete A, Cabrales P, Tsai A, Intaglietta M. Microvascular benefits of increasing plasma viscosity and maintaining blood viscosity: counterintuitive experimental findings. Biorheology. 2009; 46(3):167-79. PMID: 19581725.
        View in: PubMed
      33. Cabrales P, Tsai A, Intaglietta M. Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H2212-8. PMID: 18835914; PMCID: PMC2614583.
      34. Cabrales P, Tsai A, Ananda K, Acharya SA, Intaglietta M. Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin. Resuscitation. 2008 Oct; 79(1):139-46. PMID: 18621463; PMCID: PMC2758307.
      35. Cabrales P, Tsai A, Intaglietta M. Balance between vasoconstriction and enhanced oxygen delivery. Transfusion. 2008 Oct; 48(10):2087-95. PMID: 18631171; PMCID: PMC2747808.
      36. Mao Q, Gundavarapu S, Patel C, Tsai A, Luks FI, De Paepe ME. The Fas system confers protection against alveolar disruption in hyperoxia-exposed newborn mice. Am J Respir Cell Mol Biol. 2008 Dec; 39(6):717-29. PMID: 18587053; PMCID: PMC2586047.
      37. Salazar Vázquez BY, Wettstein R, Cabrales P, Tsai A, Intaglietta M. Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs. blood viscosity in shock resuscitation. Biochim Biophys Acta. 2008 Oct; 1784(10):1421-7. PMID: 18502215; PMCID: PMC2886513.
      38. Martini J, Cabrales P, K A, Acharya SA, Intaglietta M, Tsai A. Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective. Crit Care. 2008; 12(2):R54. PMID: 18423033; PMCID: PMC2447609.
      39. Cabrales P, Tsai A, Intaglietta M. Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock. Resuscitation. 2008 Jun; 77(3):379-86. PMID: 18308459; PMCID: PMC3224810.
      40. Cabrales P, Tsai A, Intaglietta M. Resuscitation from hemorrhagic shock with hydroxyethyl starch and coagulation changes. Shock. 2007 Oct; 28(4):461-7. PMID: 17558350.
        View in: PubMed
      41. Cabrales P, Tsai A, Intaglietta M. Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemia. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):354-61. PMID: 17884988; PMCID: PMC2258455.
      42. Salazar Vázquez BY, Cabrales P, Tsai A, Johnson PC, Intaglietta M. Lowering of blood pressure by increasing hematocrit with non nitric oxide scavenging red blood cells. Am J Respir Cell Mol Biol. 2008 Feb; 38(2):135-42. PMID: 17709601; PMCID: PMC2214674.
      43. Acharya SA, Acharya VN, Kanika ND, Tsai A, Intaglietta M, Manjula BN. Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation. Biochem J. 2007 Aug 01; 405(3):503-11. PMID: 17425516; PMCID: PMC2267292.
      44. Tsai A, Johnson PC, Intaglietta M. Is the distribution of tissue pO(2) homogeneous? Antioxid Redox Signal. 2007 Jul; 9(7):979-84. PMID: 17508919.
        View in: PubMed
      45. Cabrales P, Intaglietta M, Tsai A. Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity. Resuscitation. 2007 Oct; 75(1):124-34. PMID: 17481796; PMCID: PMC3224809.
      46. Tsai A, Cabrales P, Johnson PC, Intaglietta M. New phosphorescence quenching oxygen measurements technique yields unusual tissue and plasma PO2 distributions. J Appl Physiol (1985). 2007 May; 102(5):2081-2; author reply 2083. PMID: 17483445.
        View in: PubMed
      47. Hangai-Hoger N, Tsai A, Cabrales P, Suematsu M, Intaglietta M. Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution. Crit Care Med. 2007 Apr; 35(4):1123-32. PMID: 17334240.
        View in: PubMed
      48. Cabrales P, Tsai A, Intaglietta M. Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity? Shock. 2007 Apr; 27(4):380-9. PMID: 17414420.
        View in: PubMed
      49. Cabrales P, Vázquez BY, Tsai A, Intaglietta M. Microvascular and capillary perfusion following glycocalyx degradation. J Appl Physiol (1985). 2007 Jun; 102(6):2251-9. PMID: 17347383.
        View in: PubMed
      50. Cabrales P, Tsai A, Intaglietta M. Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin. Antioxid Redox Signal. 2007 Mar; 9(3):375-84. PMID: 17184174.
        View in: PubMed
      51. Cabrales P, Tsai A, Intaglietta M. Perfluorocarbon in microcirculation during ischemia reperfusion. J Am Coll Surg. 2007 Feb; 204(2):225-35. PMID: 17254926.
        View in: PubMed
      52. Hangai-Hoger N, Tsai A, Cabrales P, Intaglietta M. Terminal lymphatics: the potential "lethal corner" in the distribution of tissue pO2. Lymphat Res Biol. 2007; 5(3):159-68. PMID: 18035934.
        View in: PubMed
      53. Friesenecker B, Tsai A, Dünser MW, Martini J, Hasibeder W, Intaglietta M. Lowered microvascular vessel wall oxygen consumption augments tissue pO2 during PgE1-induced vasodilation. Eur J Appl Physiol. 2007 Mar; 99(4):405-14. PMID: 17165051.
        View in: PubMed
      54. Cabrales P, Tsai A, Intaglietta M. Hemorrhagic shock resuscitation with carbon monoxide saturated blood. Resuscitation. 2007 Feb; 72(2):306-18. PMID: 17092627.
        View in: PubMed
      55. Wettstein R, Tsai A, Harder Y, Erni D, Intaglietta M. Early resuscitation with polymerized bovine hemoglobin reverses acidosis, but not peripheral tissue oxygenation, in a severe hamster shock model. Shock. 2006 Nov; 26(5):496-503. PMID: 17047521.
        View in: PubMed
      56. Tsai A, Cabrales P, Manjula BN, Acharya SA, Winslow RM, Intaglietta M. Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers. Blood. 2006 Nov 15; 108(10):3603-10. PMID: 16857991; PMCID: PMC1895434.
      57. Wettstein R, Erni D, Intaglietta M, Tsai A. Rapid restoration of microcirculatory blood flow with hyperviscous and hyperoncotic solutions lowers the transfusion trigger in resuscitation from hemorrhagic shock. Shock. 2006 Jun; 25(6):641-6. PMID: 16721273.
        View in: PubMed
      58. Cabrales P, Tsai A. Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2445-52. PMID: 16731641.
        View in: PubMed
      59. Friesenecker BE, Tsai A, Martini J, Ulmer H, Wenzel V, Hasibeder WR, Intaglietta M, Dünser MW. Arteriolar vasoconstrictive response: comparing the effects of arginine vasopressin and norepinephrine. Crit Care. 2006; 10(3):R75. PMID: 16696866; PMCID: PMC1550934.
      60. Tsai A, Cabrales P. Can the effects of vasoactivity of molecular hemoglobin-based plasma expanders be ignored? Crit Care Med. 2006 May; 34(5):1566-7. PMID: 16633264.
        View in: PubMed
      61. Martini J, Cabrales P, Tsai A, Intaglietta M. Mechanotransduction and the homeostatic significance of maintaining blood viscosity in hypotension, hypertension and haemorrhage. J Intern Med. 2006 Apr; 259(4):364-72. PMID: 16594904.
        View in: PubMed
      62. Cabrales P, Martini J, Intaglietta M, Tsai A. Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H581-90. PMID: 16517943.
        View in: PubMed
      63. Martini J, Tsai A, Cabrales P, Johnson PC, Intaglietta M. Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H310-7. PMID: 16489106.
        View in: PubMed
      64. Intaglietta M, Cabrales P, Tsai A. Microvascular perspective of oxygen-carrying and -noncarrying blood substitutes. Annu Rev Biomed Eng. 2006; 8:289-321. PMID: 16834558.
        View in: PubMed
      65. Martini J, Carpentier B, Chávez Negrete A, Cabrales P, Tsai A, Intaglietta M. Beneficial effects due to increasing blood and plasma viscosity. Clin Hemorheol Microcirc. 2006; 35(1-2):51-7. PMID: 16899906.
        View in: PubMed
      66. Hangai-Hoger N, Nacharaju P, Manjula BN, Cabrales P, Tsai A, Acharya SA, Intaglietta M. Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia. Crit Care Med. 2006 Jan; 34(1):108-17. PMID: 16374164.
        View in: PubMed
      67. Tsai A, Friesenecker B, Cabrales P, Hangai-Hoger N, Intaglietta M. The vascular wall as a regulator of tissue oxygenation. Curr Opin Nephrol Hypertens. 2006 Jan; 15(1):67-71. PMID: 16340669.
        View in: PubMed
      68. Cabrales P, Tsai A, Johnson PC, Intaglietta M. Oxygen release from arterioles with normal flow and no-flow conditions. J Appl Physiol (1985). 2006 May; 100(5):1569-76. PMID: 16384838.
        View in: PubMed
      69. Cabrales P, Tsai A, Intaglietta M. Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia. J Appl Physiol (1985). 2006 Apr; 100(4):1181-7. PMID: 16357070.
        View in: PubMed
      70. Cabrales P, Tsai A, Frangos JA, Intaglietta M. Role of endothelial nitric oxide in microvascular oxygen delivery and consumption. Free Radic Biol Med. 2005 Nov 01; 39(9):1229-37. PMID: 16214038.
        View in: PubMed
      71. Tsai A, Cabrales P, Johnson PC, Intaglietta M, Golub AS, Pittman RN. Effect of oxygen consumption by measuring method on PO2 transients associated with the passage of erythrocytes in capillaries of rat mesentery. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1777; author reply H1778-9. PMID: 16162870.
        View in: PubMed
      72. Cabrales P, Tsai A, Winslow RM, Intaglietta M. Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2392-400. PMID: 16024576.
        View in: PubMed
      73. Tsai A, Cabrales P, Intaglietta M. Blood viscosity: a factor in tissue survival? Crit Care Med. 2005 Jul; 33(7):1662-3. PMID: 16003089.
        View in: PubMed
      74. Cabrales P, Nacharaju P, Manjula BN, Tsai A, Acharya SA, Intaglietta M. Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders. Shock. 2005 Jul; 24(1):66-73. PMID: 15988323.
        View in: PubMed
      75. Cabrales P, Intaglietta M, Tsai A. Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding. Shock. 2005 Jun; 23(6):549-55. PMID: 15897809.
        View in: PubMed
      76. Johnson PC, Vandegriff K, Tsai A, Intaglietta M. Effect of acute hypoxia on microcirculatory and tissue oxygen levels in rat cremaster muscle. J Appl Physiol (1985). 2005 Apr; 98(4):1177-84. PMID: 15772057.
        View in: PubMed
      77. Manjula BN, Tsai A, Intaglietta M, Tsai CH, Ho C, Smith PK, Perumalsamy K, Kanika ND, Friedman JM, Acharya SA. Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function. Protein J. 2005 Apr; 24(3):133-46. PMID: 16096719.
        View in: PubMed
      78. Sakai H, Cabrales P, Tsai A, Tsuchida E, Intaglietta M. Oxygen release from low and normal P50 Hb vesicles in transiently occluded arterioles of the hamster window model. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2897-903. PMID: 15681705.
        View in: PubMed
      79. Cabrales P, Tsai A, Winslow RM, Intaglietta M. Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2146-53. PMID: 15637119.
        View in: PubMed
      80. Acharya SA, Friedman JM, Manjula BN, Intaglietta M, Tsai A, Winslow RM, Malavalli A, Vandegriff K, Smith PK. Enhanced molecular volume of conservatively pegylated Hb: (SP-PEG5K)6-HbA is non-hypertensive. Artif Cells Blood Substit Immobil Biotechnol. 2005; 33(3):239-55. PMID: 16152690.
        View in: PubMed
      81. Cabrales P, Tsai A, Intaglietta M. Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1708-16. PMID: 15591096.
        View in: PubMed
      82. Tsai A, Acero C, Nance PR, Cabrales P, Frangos JA, Buerk DG, Intaglietta M. Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1730-9. PMID: 15576432.
        View in: PubMed
      83. Tsai A, Cabrales P, Hangai-Hoger N, Intaglietta M. Oxygen distribution and respiration by the microcirculation. Antioxid Redox Signal. 2004 Dec; 6(6):1011-8. PMID: 15548898.
        View in: PubMed
      84. Cabrales P, Sakai H, Tsai A, Takeoka S, Tsuchida E, Intaglietta M. Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1885-92. PMID: 15563528.
        View in: PubMed
      85. Hangai-Hoger N, Tsai A, Friesenecker B, Cabrales P, Intaglietta M. Microvascular oxygen delivery and consumption following treatment with verapamil. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1515-20. PMID: 15563532.
        View in: PubMed
      86. Tsai A, Cabrales P, Intaglietta M. Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions. Transfusion. 2004 Nov; 44(11):1626-34. PMID: 15504169.
        View in: PubMed
      87. Cabrales P, Tsai A, Intaglietta M. Hyperosmotic-hyperoncotic versus hyperosmotic-hyperviscous: small volume resuscitation in hemorrhagic shock. Shock. 2004 Nov; 22(5):431-7. PMID: 15489635.
        View in: PubMed
      88. Wettstein R, Cabrales P, Erni D, Tsai A, Winslow RM, Intaglietta M. Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin. Shock. 2004 Oct; 22(4):351-7. PMID: 15377891.
        View in: PubMed
      89. Manjula BN, Tsai A, Intaglietta M, Tsai CH, Ho C, Malavalli A, Vandegriff KD, Winslow RM, Smith PK, Perumalsamy K, Devi Kanika N, Friedman JM, Acharya SA. WITHDRAWN: PEGylated hemoglobin: Role of surface configuration of PEG for the modulation of hemoglobin vasoactivity. J Biol Chem. 2004 Aug 27. PMID: 15194702.
        View in: PubMed
      90. Cabrales P, Tsai A, Intaglietta M. Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin. Am J Physiol Heart Circ Physiol. 2004 Dec; 287(6):H2825-33. PMID: 15297257.
        View in: PubMed
      91. Tsai A, Cabrales P, Intaglietta M. Oxygen-carrying blood substitutes: a microvascular perspective. Expert Opin Biol Ther. 2004 Jul; 4(7):1147-57. PMID: 15268681.
        View in: PubMed
      92. Cabrales P, Tsai A, Frangos JA, Briceño JC, Intaglietta M. Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons. Am J Physiol Heart Circ Physiol. 2004 Jul; 287(1):H320-30. PMID: 15210452.
        View in: PubMed
      93. Cabrales P, Kanika ND, Manjula BN, Tsai A, Acharya SA, Intaglietta M. Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber. Am J Physiol Heart Circ Physiol. 2004 Oct; 287(4):H1609-17. PMID: 15191899.
        View in: PubMed
      94. Friesenecker B, Tsai A, Dünser MW, Mayr AJ, Martini J, Knotzer H, Hasibeder W, Intaglietta M. Oxygen distribution in microcirculation after arginine vasopressin-induced arteriolar vasoconstriction. Am J Physiol Heart Circ Physiol. 2004 Oct; 287(4):H1792-800. PMID: 15191895.
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