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    Amy Pasquinelli

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0349
    CA La Jolla 92093
    Phone858-822-3006
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Role of miRNA Argonautes in organismal aging
      NIH/NIA R01AG056562Sep 1, 2017 - Apr 30, 2022
      Role: Principal Investigator
      Role of Argonaute in miRNA biogenesis and function
      NIH/NIGMS R01GM071654Jun 1, 2004 - Jan 31, 2018
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Pasquinelli A. A sense-able microRNA. Genes Dev. 2016 Sep 15; 30(18):2019-2020. PMID: 27798846.
        View in: PubMed
      2. Broughton JP, Pasquinelli A. A tale of two sequences: microRNA-target chimeric reads. Genet Sel Evol. 2016; 48(1):31. PMID: 27044644.
        View in: PubMed
      3. Mondol V, Ahn BC, Pasquinelli A. Splicing remodels the let-7 primary microRNA to facilitate Drosha processing in Caenorhabditis elegans. RNA. 2015 Aug; 21(8):1396-403. PMID: 26081559.
        View in: PubMed
      4. Pasquinelli A. MicroRNAs: heralds of the noncoding RNA revolution. RNA. 2015 Apr; 21(4):709-10. PMID: 25780202.
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      5. Van Wynsberghe PM, Pasquinelli A. Period homolog LIN-42 regulates miRNA transcription to impact developmental timing. Worm. 2014 Oct-Dec; 3(4):e974453. PMID: 26435883.
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      6. Fonslow BR, Moresco JJ, Tu PG, Aalto AP, Pasquinelli A, Dillin AG, Yates Iii JR. Mass spectrometry-based shotgun proteomic analysis of C. elegans protein complexes. WormBook. 2014; 1-18. PMID: 24967700.
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      7. Van Wynsberghe PM, Finnegan EF, Stark T, Angelus EP, Homan KE, Yeo GW, Pasquinelli A. The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans. Dev Biol. 2014 Jun 15; 390(2):126-35. PMID: 24699545.
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      8. Lima SA, Pasquinelli A. Identification of miRNAs and Their Targets in C. elegans. Adv Exp Med Biol. 2014; 825:431-50. PMID: 25201113.
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      9. Pasquinelli A. The primary target of let-7 microRNA. Biochem Soc Trans. 2013 Aug; 41(4):821-4. PMID: 23863138.
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      10. Broughton JP, Pasquinelli A. Identifying Argonaute binding sites in Caenorhabditis elegans using iCLIP. Methods. 2013 Sep 15; 63(2):119-25. PMID: 23583680.
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      11. Hunter SE, Finnegan EF, Zisoulis DG, Lovci MT, Melnik-Martinez KV, Yeo GW, Pasquinelli A. Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans. PLoS Genet. 2013; 9(3):e1003353. PMID: 23516374.
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      12. Massirer KB, Pasquinelli A. MicroRNAs that interfere with RNAi. Worm. 2013 Jan 1; 2(1):e21835. PMID: 24058860.
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      13. Kai ZS, Finnegan EF, Huang S, Pasquinelli A. Multiple cis-elements and trans-acting factors regulate dynamic spatio-temporal transcription of let-7 in Caenorhabditis elegans. Dev Biol. 2013 Feb 1; 374(1):223-33. PMID: 23201578.
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      14. Finnegan EF, Pasquinelli A. MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol. 2013 Jan-Feb; 48(1):51-68. PMID: 23163351.
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      15. Pasquinelli A. Birthing histone mRNAs by CSR-1 section. EMBO J. 2012 Oct 3; 31(19):3790-1. PMID: 22960639.
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      16. Zisoulis DG, Kai ZS, Chang RK, Pasquinelli A. Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature. 2012 Jun 28; 486(7404):541-4. PMID: 22722835.
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      17. Aalto AP, Pasquinelli A. Small non-coding RNAs mount a silent revolution in gene expression. Curr Opin Cell Biol. 2012 Jun; 24(3):333-40. PMID: 22464106.
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      18. Pasquinelli A. MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet. 2012 Apr; 13(4):271-82. PMID: 22411466.
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      19. Massirer KB, Perez SG, Mondol V, Pasquinelli A. The miR-35-41 family of microRNAs regulates RNAi sensitivity in Caenorhabditis elegans. PLoS Genet. 2012; 8(3):e1002536. PMID: 22412382.
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      20. Pasquinelli A. A team effort blocks the ribosome in its tracks. Nat Struct Mol Biol. 2012 Feb; 19(2):133-4. PMID: 22301874.
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      21. Mondol V, Pasquinelli A. Let's make it happen: the role of let-7 microRNA in development. Curr Top Dev Biol. 2012; 99:1-30. PMID: 22365733.
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      22. Van Wynsberghe PM, Kai ZS, Massirer KB, Burton VH, Yeo GW, Pasquinelli A. LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans. Nat Struct Mol Biol. 2011 Mar; 18(3):302-8. PMID: 21297634.
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      23. Zisoulis DG, Yeo GW, Pasquinelli A. Comprehensive identification of miRNA target sites in live animals. Methods Mol Biol. 2011; 732:169-85. PMID: 21431713.
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      24. Bracht JR, Van Wynsberghe PM, Mondol V, Pasquinelli A. Regulation of lin-4 miRNA expression, organismal growth and development by a conserved RNA binding protein in C. elegans. Dev Biol. 2010 Dec 15; 348(2):210-21. PMID: 20937268.
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      25. Pasquinelli A. Molecular biology. Paring miRNAs through pairing. Science. 2010 Jun 18; 328(5985):1494-5. PMID: 20558697.
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      26. Hinton A, Afrikanova I, Wilson M, King CC, Maurer B, Yeo GW, Hayek A, Pasquinelli A. A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. Stem Cells Dev. 2010 Jun; 19(6):797-807. PMID: 19807270.
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      27. Godshalk SE, Melnik-Martinez KV, Pasquinelli A, Slack FJ. MicroRNAs and cancer: a meeting summary of the eponymous Keystone Conference. Epigenetics. 2010 Feb 16; 5(2):164-8. PMID: 20168081.
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      28. Kai Z, Pasquinelli A. A genome wide view of hunchback-like-1 targets. Cell Cycle. 2010 Jan 15; 9(2):230-1. PMID: 20061795.
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      29. Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Liang TY, Pasquinelli A, Yeo GW. Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Nat Struct Mol Biol. 2010 Feb; 17(2):173-9. PMID: 20062054.
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      30. Kai ZS, Pasquinelli A. MicroRNA assassins: factors that regulate the disappearance of miRNAs. Nat Struct Mol Biol. 2010 Jan; 17(1):5-10. PMID: 20051982.
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      31. Holtz J, Pasquinelli A. Uncoupling of lin-14 mRNA and protein repression by nutrient deprivation in Caenorhabditis elegans. RNA. 2009 Mar; 15(3):400-5. PMID: 19155321.
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      32. Norden-Krichmar TM, Holtz J, Pasquinelli A, Gaasterland T. Computational prediction and experimental validation of Ciona intestinalis microRNA genes. BMC Genomics. 2007; 8:445. PMID: 18047675.
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      33. Chendrimada TP, Finn KJ, Ji X, Baillat D, Gregory RI, Liebhaber SA, Pasquinelli A, Shiekhattar R. MicroRNA silencing through RISC recruitment of eIF6. Nature. 2007 Jun 14; 447(7146):823-8. PMID: 17507929.
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      34. Massirer KB, Pasquinelli A. The evolving role of microRNAs in animal gene expression. Bioessays. 2006 May; 28(5):449-52. PMID: 16615087.
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      35. Pasquinelli A. Demystifying small RNA pathways. Dev Cell. 2006 Apr; 10(4):419-24. PMID: 16625708.
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      36. Bagga S, Pasquinelli A. Identification and analysis of microRNAs. Genet Eng (N Y). 2006; 27:1-20. PMID: 16382868.
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      37. Lancman JJ, Caruccio NC, Harfe BD, Pasquinelli A, Schageman JJ, Pertsemlidis A, Fallon JF. Analysis of the regulation of lin-41 during chick and mouse limb development. Dev Dyn. 2005 Dec; 234(4):948-60. PMID: 16245339.
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      38. Bagga S, Bracht J, Hunter S, Massirer K, Holtz J, Eachus R, Pasquinelli A. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell. 2005 Aug 26; 122(4):553-63. PMID: 16122423.
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      39. Pasquinelli A, Hunter S, Bracht J. MicroRNAs: a developing story. Curr Opin Genet Dev. 2005 Apr; 15(2):200-5. PMID: 15797203.
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      40. Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. Functional genomic analysis of RNA interference in C. elegans. Science. 2005 May 20; 308(5725):1164-7. PMID: 15790806.
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      41. Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli A, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004 Oct; 36(10):1079-83. PMID: 15361871.
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      42. Bracht J, Hunter S, Eachus R, Weeks P, Pasquinelli A. Trans-splicing and polyadenylation of let-7 microRNA primary transcripts. RNA. 2004 Oct; 10(10):1586-94. PMID: 15337850.
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      43. Pasquinelli A, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J. Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution? Evol Dev. 2003 Jul-Aug; 5(4):372-8. PMID: 12823453.
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      44. Bashirullah A, Pasquinelli A, Kiger AA, Perrimon N, Ruvkun G, Thummel CS. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol. 2003 Jul 1; 259(1):1-8. PMID: 12812783.
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      45. Lin SY, Johnson SM, Abraham M, Vella MC, Pasquinelli A, Gamberi C, Gottlieb E, Slack FJ. The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev Cell. 2003 May; 4(5):639-50. PMID: 12737800.
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      46. Pasquinelli A, Ruvkun G. Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol. 2002; 18:495-513. PMID: 12142272.
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      47. Pasquinelli A. MicroRNAs: deviants no longer. Trends Genet. 2002 Apr; 18(4):171-3. PMID: 11932009.
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      48. Grishok A, Pasquinelli A, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001 Jul 13; 106(1):23-34. PMID: 11461699.
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      49. Hutvágner G, McLachlan J, Pasquinelli A, Bálint E, Tuschl T, Zamore PD. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 2001 Aug 3; 293(5531):834-8. PMID: 11452083.
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      50. Pasquinelli A, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000 Nov 2; 408(6808):86-9. PMID: 11081512.
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      51. Reinhart BJ, Slack FJ, Basson M, Pasquinelli A, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000 Feb 24; 403(6772):901-6. PMID: 10706289.
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      52. Pasquinelli A, Powers MA, Lund E, Forbes D, Dahlberg JE. Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14394-9. PMID: 9405623.
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      53. Pasquinelli A, Ernst RK, Lund E, Grimm C, Zapp ML, Rekosh D, Hammarskjöld ML, Dahlberg JE. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway. EMBO J. 1997 Dec 15; 16(24):7500-10. PMID: 9405378.
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      54. Pasquinelli A, Dahlberg JE, Lund E. Reverse 5' caps in RNAs made in vitro by phage RNA polymerases. RNA. 1995 Nov; 1(9):957-67. PMID: 8548660.
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      55. Greenspan DS, Pasquinelli A. BstUI and DpnII RFLPs at the COL5A1 gene. Hum Mol Genet. 1994 Feb; 3(2):385. PMID: 7911701.
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