|School||University of California, San Diego|
|Address||9500 Gilman Drive #0666|
CA La Jolla 92093
Biology of the inner and middle ears, including hair cell gene and fate regulation, drug and noise damage to hearing, inner ear neuronal targeting, pathogenesis and recovery mechanisms in otitis media, and drug delivery to the middle and inner ears.Research Topics
Current Project Titles
- Cell Biology
- Drug Delivery
- Infectious Disease
- Innate Immunity
- Molecular Biology
- Regeneration/Stem Cells
- Structural Biology
- Translational Research
- Recovery from blast-induced hearing loss (DoD)
- A biological interface for the cochlear implant (VA)
- Middle ear responses in otitis media (NIH)
- Mechanisms of persistence and recovery in otitis media (NIH)
- New methods for the treatment of hearing and balance disorders (Pending)
My laboratory studies the basic biology of hearing. A major focus of the group is the sensory hair cells of the cochlea. This includes studies of gene regulation in these cells, as well as fate determination by combinatorial transcription factor coding. We also study cellular mechanisms of hair cell damage and death induced by ototoxic drugs, noise trauma and excitotoxicity. A second area of interest is the two types of afferent neurons in the cochlea. In particular the type II neurons that innervate outer hair cells are poorly understood with respect to their function and the regulation of their complex pathfinding to their target hair cells. We also study pathogenesis and recovery of the middle ear mucosa during otitis media, with a focus on cell phenotype determination and innate immunity. Finally, we are interested in novel methods for drug delivery to the middle and inner ears.
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