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    Alice Zemljic-Harpf

    TitleAssistant Researcher
    SchoolUniversity of California, San Diego
    DepartmentAnesthesiology
    Address9500 Gilman Drive #9151
    CA La Jolla 92093
    Phone858-552-8585
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      Collapse Biography 
      Collapse Awards and Honors
      School of Medicine, University of California, San Diego2007Schulman Award, given to a trainee, who has demonstrated groundbreaking cardiovascular research
      American Heart Association2008New Investigator Travel Award, BCVS conference, Heart Failure: Molecular and Therapeutic Targets

      Collapse Overview 
      Collapse Overview
      My research focus is to investigate molecular pathways leading to congestive heart failure and cardiac arrhythmias. Further, commonly used drugs and their safety profiles are studied in vitro as well as in vivo, before and after the onset of heat failure.


      Collapse ORNG Applications 
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross RS, Hammond HK, Patel HH, Roth DM. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. PMID: 28498861.
        View in: PubMed
      2. Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth DM. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Res Cardiol. 2016 May; 111(3):28. PMID: 27023865.
        View in: PubMed
      3. Schilling JM, Cui W, Godoy JC, Risbrough VB, Niesman IR, Roth DM, Patel PM, Drummond JC, Patel HH, Zemljic-Harpf AE, Head BP. Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry. Behav Brain Res. 2014 Jul 1; 267:6-11. PMID: 24657594.
        View in: PubMed
      4. Zemljic-Harpf AE, Godoy JC, Platoshyn O, Asfaw EK, Busija AR, Domenighetti AA, Ross RS. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014 Mar 1; 127(Pt 5):1104-16. PMID: 24413171.
        View in: PubMed
      5. Thievessen I, Thompson PM, Berlemont S, Plevock KM, Plotnikov SV, Zemljic-Harpf A, Ross RS, Davidson MW, Danuser G, Campbell SL, Waterman CM. Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol. 2013 Jul 8; 202(1):163-77. PMID: 23836933.
        View in: PubMed
      6. Winkler U, Hirrlinger PG, Sestu M, Wilhelm F, Besser S, Zemljic-Harpf AE, Ross RS, Bornschein G, Kr├╝gel U, Ziegler WH, Hirrlinger J. Deletion of the cell adhesion adaptor protein vinculin disturbs the localization of GFAP in Bergmann glial cells. Glia. 2013 Jul; 61(7):1067-83. PMID: 23595642.
        View in: PubMed
      7. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophys J. 2013 Apr 2; 104(7):1623-33. PMID: 23561539.
        View in: PubMed
      8. Chuang JS, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI. Magn Reson Med. 2010 Nov; 64(5):1281-8. PMID: 20981782.
        View in: PubMed
      9. Mitsios JV, Prevost N, Kasirer-Friede A, Gutierrez E, Groisman A, Abrams CS, Wang Y, Litvinov RI, Zemljic-Harpf A, Ross RS, Shattil SJ. What is vinculin needed for in platelets? J Thromb Haemost. 2010 Oct; 8(10):2294-304. PMID: 20670372.
        View in: PubMed
      10. Zemljic-Harpf A, Manso AM, Ross RS. Vinculin and talin: focus on the myocardium. J Investig Med. 2009 Dec; 57(8):849-55. PMID: 19952892.
        View in: PubMed
      11. Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins GA, McCulloch AD, Ross RS. Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol. 2007 Nov; 27(21):7522-37. PMID: 17785437.
        View in: PubMed
      12. Oh YS, Jong AY, Kim DT, Li H, Wang C, Zemljic-Harpf A, Ross RS, Fishbein MC, Chen PS, Chen LS. Spatial distribution of nerve sprouting after myocardial infarction in mice. Heart Rhythm. 2006 Jun; 3(6):728-36. PMID: 16731479.
        View in: PubMed
      13. Zemljic-Harpf AE, Ponrartana S, Avalos RT, Jordan MC, Roos KP, Dalton ND, Phan VQ, Adamson ED, Ross RS. Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy. Am J Pathol. 2004 Sep; 165(3):1033-44. PMID: 15331426.
        View in: PubMed
      14. Uzui H, Harpf A, Liu M, Doherty TM, Shukla A, Chai NN, Tripathi PV, Jovinge S, Wilkin DJ, Asotra K, Shah PK, Rajavashisth TB. Increased expression of membrane type 3-matrix metalloproteinase in human atherosclerotic plaque: role of activated macrophages and inflammatory cytokines. Circulation. 2002 Dec 10; 106(24):3024-30. PMID: 12473546.
        View in: PubMed
      15. Babbitt CJ, Shai SY, Harpf AE, Pham CG, Ross RS. Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle. Histochem Cell Biol. 2002 Dec; 118(6):431-9. PMID: 12483308.
        View in: PubMed
      16. Shai SY, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, Omura M, Leil TA, Becker KD, Jiang M, Smith DJ, Cherry SR, Loftus JC, Ross RS. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res. 2002 Mar 8; 90(4):458-64. PMID: 11884376.
        View in: PubMed
      17. Shai SY, Harpf AE, Ross RS. Integrins and the myocardium. Genet Eng (N Y). 2002; 24:87-105. PMID: 12416302.
        View in: PubMed
      18. Pham CG, Harpf AE, Keller RS, Vu HT, Shai SY, Loftus JC, Ross RS. Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway. Am J Physiol Heart Circ Physiol. 2000 Dec; 279(6):H2916-26. PMID: 11087248.
        View in: PubMed
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