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    Alfredo Molinolo

    Address9500 Gilman Drive #0819
    CA La Jolla 92093
    Phone858-246-0179
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Khurana A, Chapelin F, Xu H, Acevedo JR, Molinolo A, Nguyen Q, Ahrens ET. Visualization of macrophage recruitment in head and neck carcinoma model using fluorine-19 magnetic resonance imaging. Magn Reson Med. 2017 Jul 26. PMID: 28748562.
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      2. Rojas PA, May M, Sequeira GR, Elia A, Alvarez M, Martínez P, Gonzalez P, Hewitt S, He X, Perou CM, Molinolo A, Gibbons L, Abba MC, Gass H, Lanari C. Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness. J Natl Cancer Inst. 2017 07 01; 109(7). PMID: 28376177.
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      3. Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo A, Tsien RY, Nguyen QT. Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Oral Oncol. 2017 Aug; 71:156-162. PMID: 28688684.
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      4. Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo A, Inoue A, Offermanns S, Gutkind JS. Epidermal loss of Gaq confers a migratory and differentiation defect in keratinocytes. PLoS One. 2017; 12(3):e0173692. PMID: 28301547.
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      5. Rey S, Quintavalle C, Burmeister K, Calabrese D, Schlageter M, Quagliata L, Cathomas G, Diebold J, Molinolo A, Heim MH, Terracciano LM, Matter MS. LIVER DAMAGE AND SENESCENCE INCREASES IN PATIENTS DEVELOPING HEPATOCELLULAR CARCINOMA. J Gastroenterol Hepatol. 2017 Jan 03. PMID: 28052383.
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      6. Ramnitz MS, Gourh P, Goldbach-Mansky R, Wodajo F, Ichikawa S, Econs MJ, White KE, Molinolo A, Chen MY, Heller T, Del Rivero J, Seo-Mayer P, Arabshahi B, Jackson MB, Hatab S, McCarthy E, Guthrie LC, Brillante BA, Gafni RI, Collins MT. Phenotypic and Genotypic Characterization and Treatment of a Cohort With Familial Tumoral Calcinosis/Hyperostosis-Hyperphosphatemia Syndrome. J Bone Miner Res. 2016 Oct; 31(10):1845-1854. PMID: 27164190.
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      7. Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano JA, Molinolo A, Gutkind JS. mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model. Carcinogenesis. 2016 Oct; 37(10):1014-25. PMID: 27538837.
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      8. Fadlullah MZ, Chiang IK, Dionne KR, Yee PS, Gan CP, Sam KK, Tiong KH, Wen Ng AK, Martin D, Lim KP, Kallarakkal TG, Wan Mustafa WM, Lau SH, Abraham MT, Zain RB, Abdul Rahman ZA, Molinolo A, Patel V, Gutkind JS, Tan AC, Cheong SC. Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies. Oncotarget. 2016 Apr 1; 7(19):27802-18. PMID: 27050151.
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      9. Matter MS, Marquardt JU, Andersen JB, Quintavalle C, Korokhov N, Stauffer JK, Kaji K, Decaens T, Quagliata L, Elloumi F, Hoang T, Molinolo A, Conner EA, Weber A, Heikenwalder M, Factor VM, Thorgeirsson SS. Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype. Hepatology. 2016 Jun; 63(6):1888-99. PMID: 26844528.
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      10. Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo A, Cohen EE, Califano JA, Lippman SM, Luo J, Gutkind JS. A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. Oncotarget. 2016 Mar 8; 7(10):10696-709. PMID: 26882569.
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      11. O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo A, Gutkind JS. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Ga13/RhoA axis in B cells. Oncogene. 2015 Nov 30. PMID: 26616858.
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      12. May M, Mosto J, Vazquez PM, Gonzalez P, Rojas P, Gass H, Lanari C, Molinolo A. Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer. Exp Mol Pathol. 2016 Feb; 100(1):39-44. PMID: 26551078.
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      13. Yoneda M, Molinolo A, Ward JM, Kimura S, Goodlad RA. A Simple Device to Rapidly Prepare Whole Mounts of the Mouse Intestine. J Vis Exp. 2015; (105). PMID: 26556642.
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      14. Milenic DE, Molinolo A, Solivella MS, Banaga E, Torgue J, Besnainou S, Brechbiel MW, Baidoo KE. Toxicological Studies of 212Pb Intravenously or Intraperitoneally Injected into Mice for a Phase 1 Trial. Pharmaceuticals (Basel). 2015; 8(3):416-34. PMID: 26213947.
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      15. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo A, Gutkind JS. Inactivation of a Gas-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015 Jun; 17(6):793-803. PMID: 25961504.
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      16. Doçi CL, Mikelis CM, Lionakis MS, Molinolo A, Gutkind JS. Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma. Cancer Res. 2015 Jul 15; 75(14):2937-48. PMID: 25952650.
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      17. Zoratti GL, Tanabe LM, Varela FA, Murray AS, Bergum C, Colombo É, Lang JE, Molinolo A, Leduc R, Marsault E, Boerner J, List K. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun. 2015; 6:6776. PMID: 25873032.
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      18. Madera D, Vitale-Cross L, Martin D, Schneider A, Molinolo A, Gangane N, Carey TE, McHugh JB, Komarck CM, Walline HM, William WN, Seethala RR, Ferris RL, Gutkind JS. Prevention of Tumor Growth Driven by PIK3CA and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3. Cancer Prev Res (Phila). 2015 Mar; 8(3):197-207. PMID: 25681087.
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      19. Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo A, Gutkind JS. SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gai/mTORC1 axis. FASEB J. 2015 Mar; 29(3):1056-68. PMID: 25466898.
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      20. Williams KA, Lee M, Hu Y, Andreas J, Patel SJ, Zhang S, Chines P, Elkahloun A, Chandrasekharappa S, Gutkind JS, Molinolo A, Crawford NP. A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes. PLoS Genet. 2014 Nov; 10(11):e1004809. PMID: 25411967.
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      21. Wargon V, Riggio M, Giulianelli S, Sequeira GR, Rojas P, May M, Polo ML, Gorostiaga MA, Jacobsen B, Molinolo A, Novaro V, Lanari C. Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters. Int J Cancer. 2015 Jun 1; 136(11):2680-92. PMID: 25363551.
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      22. Gan CP, Patel V, Mikelis CM, Zain RB, Molinolo A, Abraham MT, Teo SH, Abdul Rahman ZA, Gutkind JS, Cheong SC. Heterotrimeric G-protein alpha-12 (Ga12) subunit promotes oral cancer metastasis. Oncotarget. 2014 Oct 30; 5(20):9626-40. PMID: 25275299.
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      23. Martin D, Abba MC, Molinolo A, Vitale-Cross L, Wang Z, Zaida M, Delic NC, Samuels Y, Lyons JG, Gutkind JS. The head and neck cancer cell oncogenome: A platform for the development of precision molecular therapies. Oncotarget. 2014 Oct 15; 5(19):8906-23. PMID: 25275298.
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      24. Smith JP, Cooper TK, McGovern CO, Gilius EL, Zhong Q, Liao J, Molinolo A, Gutkind JS, Matters GL. Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice. Pancreas. 2014 Oct; 43(7):1050-9. PMID: 25058882.
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      25. Wang Z, Martin D, Molinolo A, Patel V, Iglesias-Bartolome R, Sol Degese M, Vitale-Cross L, Chen Q, Gutkind JS. mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations. J Natl Cancer Inst. 2014 Sep; 106(9). PMID: 25099740.
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      26. Farsaci B, Donahue RN, Coplin MA, Grenga I, Lepone LM, Molinolo A, Hodge JW. Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines. Cancer Immunol Res. 2014 Nov; 2(11):1090-102. PMID: 25092771.
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      27. Madsen DH, Szabo R, Molinolo A, Bugge TH. TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition. Biochem J. 2014 Aug 1; 461(3):487-95. PMID: 24832573.
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      28. Peters DE, Hoover B, Cloud LG, Liu S, Molinolo A, Leppla SH, Bugge TH. Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities. Toxicol Appl Pharmacol. 2014 Sep 1; 279(2):220-9. PMID: 24971906.
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      29. Sequeira G, Vanzulli SI, Rojas P, Lamb C, Colombo L, May M, Molinolo A, Lanari C. The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer. Oncotarget. 2014 May 30; 5(10):3246-60. PMID: 24912774.
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      30. Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo A, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell. 2014 Jun 16; 25(6):831-45. PMID: 24882515.
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      31. Wang HD, Boyce AM, Tsai JY, Gafni RI, Farley FA, Kasa-Vubu JZ, Molinolo A, Collins MT. Effects of denosumab treatment and discontinuation on human growth plates. J Clin Endocrinol Metab. 2014 Mar; 99(3):891-7. PMID: 24423331.
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      32. Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo A, Hoover SB, Rodriguez-Canales J, Hewitt SM. Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. Pigment Cell Melanoma Res. 2014 Jan; 27(1):37-47. PMID: 24128326.
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      33. Leelahavanichkul K, Amornphimoltham P, Molinolo A, Basile JR, Koontongkaew S, Gutkind JS. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol. 2014 Feb; 8(1):105-18. PMID: 24216180.
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      34. Ono M, Inkson CA, Sonn R, Kilts TM, de Castro LF, Maeda A, Fisher LW, Robey PG, Berendsen AD, Li L, McCartney-Francis N, Brown AC, Crawford NP, Molinolo A, Jain A, Fedarko NS, Young MF. WISP1/CCN4: a potential target for inhibiting prostate cancer growth and spread to bone. PLoS One. 2013; 8(8):e71709. PMID: 23977121.
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      35. Coppock JD, Wieking BG, Molinolo A, Gutkind JS, Miskimins WK, Lee JH. Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition. Neoplasia. 2013 Jun; 15(6):620-30. PMID: 23730210.
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      36. Martin D, Nguyen Q, Molinolo A, Gutkind JS. Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene. Oncogene. 2014 May 1; 33(18):2405-12. PMID: 23708663.
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      37. Sahores A, Luque GM, Wargon V, May M, Molinolo A, Becu-Villalobos D, Lanari C, Lamb CA. Novel, low cost, highly effective, handmade steroid pellets for experimental studies. PLoS One. 2013; 8(5):e64049. PMID: 23691144.
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      38. Squarize CH, Castilho RM, Abrahao AC, Molinolo A, Lingen MW, Gutkind JS. PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia. 2013 May; 15(5):461-71. PMID: 23633918.
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      39. Patel SJ, Molinolo A, Gutkind S, Crawford NP. Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma. PLoS One. 2013; 8(4):e61848. PMID: 23620793.
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      40. Amornphimoltham P, Rechache K, Thompson J, Masedunskas A, Leelahavanichkul K, Patel V, Molinolo A, Gutkind JS, Weigert R. Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res. 2013 Mar 15; 19(6):1375-88. PMID: 23340300.
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      41. Giulianelli S, Molinolo A, Lanari C. Targeting progesterone receptors in breast cancer. Vitam Horm. 2013; 93:161-84. PMID: 23810006.
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      42. Patel V, Martin D, Malhotra R, Marsh CA, Doçi CL, Veenstra TD, Nathan CA, Sinha UK, Singh B, Molinolo A, Rusling JF, Gutkind JS. DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays. Oral Oncol. 2013 Feb; 49(2):93-101. PMID: 23010602.
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      43. Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo A, Mitchell JB, Gutkind JS. mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell. 2012 Sep 7; 11(3):401-14. PMID: 22958932.
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      44. Rudmann D, Cardiff R, Chouinard L, Goodman D, Küttler K, Marxfeld H, Molinolo A, Treumann S, Yoshizawa K. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. Toxicol Pathol. 2012 Aug; 40(6 Suppl):7S-39S. PMID: 22949413.
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      45. Tamburrino A, Molinolo A, Salerno P, Chernock RD, Raffeld M, Xi L, Gutkind JS, Moley JF, Wells SA, Santoro M. Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases. Clin Cancer Res. 2012 Jul 1; 18(13):3532-40. PMID: 22753663.
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      46. Boyce AM, Chong WH, Yao J, Gafni RI, Kelly MH, Chamberlain CE, Bassim C, Cherman N, Ellsworth M, Kasa-Vubu JZ, Farley FA, Molinolo A, Bhattacharyya N, Collins MT. Denosumab treatment for fibrous dysplasia. J Bone Miner Res. 2012 Jul; 27(7):1462-70. PMID: 22431375.
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      47. Gandini NA, Fermento ME, Salomón DG, Blasco J, Patel V, Gutkind JS, Molinolo A, Facchinetti MM, Curino AC. Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas. Exp Mol Pathol. 2012 Oct; 93(2):237-45. PMID: 22580187.
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      48. Peters DE, Zhang Y, Molinolo A, Miller-Randolph S, Szabo R, Bugge TH, Leppla SH, Liu S. Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis. Biochem Biophys Res Commun. 2012 Jun 8; 422(3):393-7. PMID: 22575514.
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      49. Lanari C, Wargon V, Rojas P, Molinolo A. Antiprogestins in breast cancer treatment: are we ready? Endocr Relat Cancer. 2012 Jun; 19(3):R35-50. PMID: 22351709.
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      50. Vitale-Cross L, Molinolo A, Martin D, Younis RH, Maruyama T, Patel V, Chen W, Schneider A, Gutkind JS. Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions. Cancer Prev Res (Phila). 2012 Apr; 5(4):562-73. PMID: 22467081.
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      51. Degese MS, Mendizabal JE, Gandini NA, Gutkind JS, Molinolo A, Hewitt SM, Curino AC, Coso OA, Facchinetti MM. Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. Lung Cancer. 2012 Jul; 77(1):168-75. PMID: 22418244.
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      52. Molinolo A, Marsh C, El Dinali M, Gangane N, Jennison K, Hewitt S, Patel V, Seiwert TY, Gutkind JS. mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas. Clin Cancer Res. 2012 May 1; 18(9):2558-68. PMID: 22409888.
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      53. Giulianelli S, Vaqué JP, Soldati R, Wargon V, Vanzulli SI, Martins R, Zeitlin E, Molinolo A, Helguero LA, Lamb CA, Gutkind JS, Lanari C. Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters. Cancer Res. 2012 May 1; 72(9):2416-27. PMID: 22396492.
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      54. Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo A, Wikenheiser-Brokamp KA, Wells SI. Future directions and treatment strategies for head and neck squamous cell carcinomas. Transl Res. 2012 Sep; 160(3):167-77. PMID: 22683420.
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      55. Giulianelli S, Vaqué JP, Wargon V, Soldati R, Vanzulli SI, Martins R, Zeitlin E, Helguero L, Lamb C, Molinolo A, Gutkind JS, Lanari C. [The role of estrogen receptor alpha in breast cancer cell proliferation mediated by progestins]. Medicina (B Aires). 2012; 72(4):315-20. PMID: 22892083.
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      56. Kosa P, Szabo R, Molinolo A, Bugge TH. Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis. Oncogene. 2012 Aug 9; 31(32):3679-95. PMID: 22139080.
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      57. Cerliani JP, Vanzulli SI, Piñero CP, Bottino MC, Sahores A, Nuñez M, Varchetta R, Martins R, Zeitlin E, Hewitt SM, Molinolo A, Lanari C, Lamb CA. Associated expressions of FGFR-2 and FGFR-3: from mouse mammary gland physiology to human breast cancer. Breast Cancer Res Treat. 2012 Jun; 133(3):997-1008. PMID: 22124578.
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      58. Bian Y, Hall B, Sun ZJ, Molinolo A, Chen W, Gutkind JS, Waes CV, Kulkarni AB. Loss of TGF-ß signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. Oncogene. 2012 Jul 12; 31(28):3322-32. PMID: 22037217.
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      59. Patel V, Marsh CA, Dorsam RT, Mikelis CM, Masedunskas A, Amornphimoltham P, Nathan CA, Nathan CA, Singh B, Weigert R, Molinolo A, Gutkind JS. Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. Cancer Res. 2011 Nov 15; 71(22):7103-12. PMID: 21975930.
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      60. Prickett TD, Wei X, Cardenas-Navia I, Teer JK, Lin JC, Walia V, Gartner J, Jiang J, Cherukuri PF, Molinolo A, Davies MA, Gershenwald JE, Stemke-Hale K, Rosenberg SA, Margulies EH, Samuels Y. Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma. Nat Genet. 2011 Nov; 43(11):1119-26. PMID: 21946352.
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      61. Yagi H, Tan W, Dillenburg-Pilla P, Armando S, Amornphimoltham P, Simaan M, Weigert R, Molinolo A, Bouvier M, Gutkind JS. A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells. Sci Signal. 2011 Sep 20; 4(191):ra60. PMID: 21934106.
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      62. Sales KU, Hobson JP, Wagenaar-Miller R, Szabo R, Rasmussen AL, Bey A, Shah MF, Molinolo A, Bugge TH. Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT. PLoS One. 2011; 6(8):e23261. PMID: 21853097.
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      63. Martin D, Galisteo R, Molinolo A, Wetzker R, Hirsch E, Gutkind JS. PI3K? mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell. 2011 Jun 14; 19(6):805-13. PMID: 21665152.
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      64. Chong WH, Molinolo A, Chen CC, Collins MT. Tumor-induced osteomalacia. Endocr Relat Cancer. 2011 Jun; 18(3):R53-77. PMID: 21490240.
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      65. Schafer JM, Peters DE, Morley T, Liu S, Molinolo A, Leppla SH, Bugge TH. Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin. PLoS One. 2011; 6(5):e20532. PMID: 21655226.
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      66. Szabo R, Rasmussen AL, Moyer AB, Kosa P, Schafer JM, Molinolo A, Gutkind JS, Bugge TH. c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase. Oncogene. 2011 Apr 28; 30(17):2003-16. PMID: 21217780.
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      67. Patel V, Iglesias-Bartolome R, Siegele B, Marsh CA, Leelahavanichkul K, Molinolo A, Gutkind JS. Cellular systems for studying human oral squamous cell carcinomas. Adv Exp Med Biol. 2011; 720:27-38. PMID: 21901616.
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      68. Bhirde AA, Patel S, Sousa AA, Patel V, Molinolo A, Ji Y, Leapman RD, Gutkind JS, Rusling JF. Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. Nanomedicine (Lond). 2010 Dec; 5(10):1535-46. PMID: 21143032.
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      69. Abrahao AC, Castilho RM, Squarize CH, Molinolo A, dos Santos-Pinto D, Gutkind JS. A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. Oral Oncol. 2010 Dec; 46(12):880-7. PMID: 20951077.
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      70. Wei X, Prickett TD, Viloria CG, Molinolo A, Lin JC, Cardenas-Navia I, Cruz P. Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma. Mol Cancer Res. 2010 Nov; 8(11):1513-25. PMID: 21047771.
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      71. Giulianelli S, Herschkowitz JI, Patel V, Lamb CA, Gutkind JS, Molinolo A, Perou CM, Lanari C. MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements. Breast Cancer Res Treat. 2011 Aug; 129(1):49-67. PMID: 20890655.
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      72. Ma T, Jham BC, Hu J, Friedman ER, Basile JR, Molinolo A, Sodhi A, Montaner S. Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14363-8. PMID: 20660728.
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      73. Fabris VT, Sahores A, Vanzulli SI, Colombo L, Molinolo A, Lanari C, Lamb CA. Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth. BMC Cancer. 2010; 10:293. PMID: 20553594.
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      74. Bottino MC, Cerliani JP, Rojas P, Giulianelli S, Soldati R, Mondillo C, Gorostiaga MA, Pignataro OP, Calvo JC, Gutkind JS. Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects. Breast Cancer Res Treat. 2011 Apr; 126(3):621-36. PMID: 20535544.
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      75. Connolly BM, Choi EY, Gårdsvoll H, Bey AL, Currie BM, Chavakis T, Liu S, Molinolo A, Ploug M, Leppla SH, Bugge TH. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood. 2010 Sep 2; 116(9):1593-603. PMID: 20466854.
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      76. Novosyadlyy R, Lann DE, Vijayakumar A, Rowzee A, Lazzarino DA, Fierz Y, Carboni JM, Gottardis MM, Pennisi PA, Molinolo A, Kurshan N, Mejia W, Santopietro S, Yakar S, Wood TL, LeRoith D. Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. Cancer Res. 2010 Jan 15; 70(2):741-51. PMID: 20068149.
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      77. Cerliani JP, Giulianelli S, Sahores A, Wargon V, Gongora A, Baldi A, Molinolo A, Lamb CE, Lanari C. Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia. Medicina (B Aires). 2010; 70(6):529-32. PMID: 21163742.
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      78. Soldati R, Wargon V, Cerliani JP, Giulianelli S, Vanzulli SI, Gorostiaga MA, Bolado J, do Campo P, Molinolo A, Vollmer G, Lanari C. Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta? Breast Cancer Res Treat. 2010 Oct; 123(3):709-24. PMID: 20012353.
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      79. Sramkova M, Masedunskas A, Parente L, Molinolo A, Weigert R. Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1347-57. PMID: 19794147.
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      80. List K, Kosa P, Szabo R, Bey AL, Wang CB, Molinolo A, Bugge TH. Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol. 2009 Oct; 175(4):1453-63. PMID: 19717635.
        View in: PubMed
      81. Bian Y, Terse A, Du J, Hall B, Molinolo A, Zhang P, Chen W, Flanders KC, Gutkind JS, Wakefield LM, Kulkarni AB. Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res. 2009 Jul 15; 69(14):5918-26. PMID: 19584284.
        View in: PubMed
      82. Raimondi AR, Molinolo A, Gutkind JS. Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res. 2009 May 15; 69(10):4159-66. PMID: 19435901.
        View in: PubMed
      83. Vitale-Cross L, Czerninski R, Amornphimoltham P, Patel V, Molinolo A, Gutkind JS. Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer. Cancer Prev Res (Phila). 2009 May; 2(5):419-22. PMID: 19401522.
        View in: PubMed
      84. Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo A, Fetsch P, Filie AC, O'Connell MP, Banister CE, Howard JD, Buckhaults P, Weeraratna AT, Brody LC, Rosenberg SA, Samuels Y. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nat Genet. 2009 May; 41(5):518-20. PMID: 19330028.
        View in: PubMed
      85. Lanari C, Lamb CA, Fabris VT, Helguero LA, Soldati R, Bottino MC, Giulianelli S, Cerliani JP, Wargon V, Molinolo A. The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer. Endocr Relat Cancer. 2009 Jun; 16(2):333-50. PMID: 19190078.
        View in: PubMed
      86. Czerninski R, Amornphimoltham P, Patel V, Molinolo A, Gutkind JS. Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. Cancer Prev Res (Phila). 2009 Jan; 2(1):27-36. PMID: 19139015.
        View in: PubMed
      87. Amornphimoltham P, Leelahavanichkul K, Molinolo A, Patel V, Gutkind JS. Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions. Clin Cancer Res. 2008 Dec 15; 14(24):8094-101. PMID: 19073969.
        View in: PubMed
      88. Giulianelli S, Cerliani JP, Lamb CA, Fabris VT, Bottino MC, Gorostiaga MA, Novaro V, Góngora A, Baldi A, Molinolo A, Lanari C. Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis. Int J Cancer. 2008 Dec 1; 123(11):2518-31. PMID: 18767044.
        View in: PubMed
      89. Molinolo A, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS. Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol. 2009 Apr-May; 45(4-5):324-34. PMID: 18805044.
        View in: PubMed
      90. Szabo R, Hobson JP, List K, Molinolo A, Lin CY, Bugge TH. Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem. 2008 Oct 24; 283(43):29495-504. PMID: 18713750.
        View in: PubMed
      91. Wargon V, Helguero LA, Bolado J, Rojas P, Novaro V, Molinolo A, Lanari C. Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas. Breast Cancer Res Treat. 2009 Aug; 116(3):449-60. PMID: 18677559.
        View in: PubMed
      92. Sausville J, Molinolo A, Cheng X, Frampton J, Takebe N, Gutkind JS, Feldman RA. RCAS/SCL-TVA animal model allows targeted delivery of polyoma middle T oncogene to vascular endothelial progenitors in vivo and results in hemangioma development. Clin Cancer Res. 2008 Jun 15; 14(12):3948-55. PMID: 18559617.
        View in: PubMed
      93. Saikkonen B, Pareek TK, Agarwal N, Molinolo A, Kriete M, Kulkarni AB. Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions. Cell Cycle. 2008 Mar 15; 7(6):750-3. PMID: 18239462.
        View in: PubMed
      94. Patel V, Hood BL, Molinolo A, Lee NH, Conrads TP, Braisted JC, Krizman DB, Veenstra TD, Gutkind JS. Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression. Clin Cancer Res. 2008 Feb 15; 14(4):1002-14. PMID: 18281532.
        View in: PubMed
      95. Liu S, Wang H, Currie BM, Molinolo A, Leung HJ, Moayeri M, Basile JR, Alfano RW, Gutkind JS, Frankel AE, Bugge TH, Leppla SH. Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem. 2008 Jan 4; 283(1):529-40. PMID: 17974567.
        View in: PubMed
      96. List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH. Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem. 2007 Dec 14; 282(50):36714-23. PMID: 17940283.
        View in: PubMed
      97. List K, Hobson JP, Molinolo A, Bugge TH. Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase. J Cell Physiol. 2007 Oct; 213(1):237-45. PMID: 17471493.
        View in: PubMed
      98. Molinolo A, Hewitt SM, Amornphimoltham P, Keelawat S, Rangdaeng S, Meneses García A, Raimondi AR, Jufe R, Itoiz M, Gao Y, Saranath D, Kaleebi GS, Yoo GH, Leak L, Myers EM, Shintani S, Wong D, Massey HD, Yeudall WA, Lonardo F, Ensley J, Gutkind JS. Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res. 2007 Sep 1; 13(17):4964-73. PMID: 17785546.
        View in: PubMed
      99. Honjo Y, Bian Y, Kawakami K, Molinolo A, Longenecker G, Boppana R, Larsson J, Karlsson S, Gutkind JS, Puri RK, Kulkarni AB. TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle. 2007 Jun 1; 6(11):1360-6. PMID: 17534148.
        View in: PubMed
      100. Nandula SR, Amarnath S, Molinolo A, Bandyopadhyay BC, Hall B, Goldsmith CM, Zheng C, Larsson J, Sreenath T, Chen W, Ambudkar IS, Karlsson S, Baum BJ, Kulkarni AB. Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands. Arthritis Rheum. 2007 Jun; 56(6):1798-805. PMID: 17530708.
        View in: PubMed
      101. Castilho RM, Squarize CH, Patel V, Millar SE, Zheng Y, Molinolo A, Gutkind JS. Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene. 2007 Aug 2; 26(35):5078-85. PMID: 17334398.
        View in: PubMed
      102. Montero Girard G, Vanzulli SI, Cerliani JP, Bottino MC, Bolado J, Vela J, Becu-Villalobos D, Benavides F, Gutkind S, Patel V, Molinolo A, Lanari C. Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment. Breast Cancer Res. 2007; 9(2):R22. PMID: 17341305.
        View in: PubMed
      103. Sulek J, Wagenaar-Miller RA, Shireman J, Molinolo A, Madsen DH, Engelholm LH, Behrendt N, Bugge TH. Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer. J Histochem Cytochem. 2007 Apr; 55(4):347-53. PMID: 17189524.
        View in: PubMed
      104. Szabo R, Molinolo A, List K, Bugge TH. Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development. Oncogene. 2007 Mar 8; 26(11):1546-56. PMID: 16983341.
        View in: PubMed
      105. Sodhi A, Chaisuparat R, Hu J, Ramsdell AK, Manning BD, Sausville EA, Sawai ET, Molinolo A, Gutkind JS, Montaner S. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell. 2006 Aug; 10(2):133-43. PMID: 16904612.
        View in: PubMed
      106. Benakanakere I, Besch-Williford C, Schnell J, Brandt S, Ellersieck MR, Molinolo A, Hyder SM. Natural and synthetic progestins accelerate 7,12-dimethylbenz[a]anthracene-initiated mammary tumors and increase angiogenesis in Sprague-Dawley rats. Clin Cancer Res. 2006 Jul 1; 12(13):4062-71. PMID: 16818706.
        View in: PubMed
      107. Raimondi AR, Vitale-Cross L, Amornphimoltham P, Gutkind JS, Molinolo A. Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. Am J Pathol. 2006 May; 168(5):1654-65. PMID: 16651631.
        View in: PubMed
      108. List K, Szabo R, Molinolo A, Nielsen BS, Bugge TH. Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis. Am J Pathol. 2006 May; 168(5):1513-25. PMID: 16651618.
        View in: PubMed
      109. Raimondi AR, Molinolo A, Itoiz ME. Fibroblast growth factor-2 expression during experimental oral carcinogenesis. Its possible role in the induction of pre-malignant fibrosis. J Oral Pathol Med. 2006 Apr; 35(4):212-7. PMID: 16519768.
        View in: PubMed
      110. Cardiff RD, Anver MR, Boivin GP, Bosenberg MW, Maronpot RR, Molinolo A, Nikitin AY, Rehg JE, Thomas GV, Russell RG, Ward JM. Precancer in mice: animal models used to understand, prevent, and treat human precancers. Toxicol Pathol. 2006; 34(6):699-707. PMID: 17074738.
        View in: PubMed
      111. Simian M, Molinolo A, Lanari C. Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regression. Am J Pathol. 2006 Jan; 168(1):270-9. PMID: 16400029.
        View in: PubMed
      112. Miura M, Miura Y, Padilla-Nash HM, Molinolo A, Fu B, Patel V, Seo BM, Sonoyama W, Zheng JJ, Baker CC, Chen W, Ried T, Shi S. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells. 2006 Apr; 24(4):1095-103. PMID: 16282438.
        View in: PubMed
      113. Lamb CA, Helguero LA, Giulianelli S, Soldati R, Vanzulli SI, Molinolo A, Lanari C. Antisense oligonucleotides targeting the progesterone receptor inhibit hormone-independent breast cancer growth in mice. Breast Cancer Res. 2005; 7(6):R1111-21. PMID: 16457691.
        View in: PubMed
      114. Amornphimoltham P, Patel V, Sodhi A, Nikitakis NG, Sauk JJ, Sausville EA, Molinolo A, Gutkind JS. Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. Cancer Res. 2005 Nov 1; 65(21):9953-61. PMID: 16267020.
        View in: PubMed
      115. List K, Szabo R, Molinolo A, Sriuranpong V, Redeye V, Murdock T, Burke B, Nielsen BS, Gutkind JS, Bugge TH. Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev. 2005 Aug 15; 19(16):1934-50. PMID: 16103220.
        View in: PubMed
      116. Curino AC, Engelholm LH, Yamada SS, Holmbeck K, Lund LR, Molinolo A, Behrendt N, Nielsen BS, Bugge TH. Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol. 2005 Jun 20; 169(6):977-85. PMID: 15967816.
        View in: PubMed
      117. Proietti C, Salatino M, Rosemblit C, Carnevale R, Pecci A, Kornblihtt AR, Molinolo A, Frahm I, Charreau EH, Schillaci R, Elizalde PV. Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells. Mol Cell Biol. 2005 Jun; 25(12):4826-40. PMID: 15923602.
        View in: PubMed
      118. Liu S, Redeye V, Kuremsky JG, Kuhnen M, Molinolo A, Bugge TH, Leppla SH. Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin. Nat Biotechnol. 2005 Jun; 23(6):725-30. PMID: 15895075.
        View in: PubMed
      119. Vanzulli SI, Soldati R, Meiss R, Colombo L, Molinolo A, Lanari C. Estrogen or antiprogestin treatment induces complete regression of pulmonary and axillary metastases in an experimental model of breast cancer progression. Carcinogenesis. 2005 Jun; 26(6):1055-63. PMID: 15774491.
        View in: PubMed
      120. Lamb CA, Fabris V, Gorostiaga MA, Helguero LA, Efeyan A, Bottino MC, Simian M, Soldati R, Sanjuan N, Molinolo A, Lanari C. Isolation of a stromal cell line from an early passage of a mouse mammary tumor line: a model for stromal parenchymal interactions. J Cell Physiol. 2005 Mar; 202(3):672-82. PMID: 15389583.
        View in: PubMed
      121. Baker H, Patel V, Molinolo A, Shillitoe EJ, Ensley JF, Yoo GH, Meneses-García A, Myers JN, El-Naggar AK, Gutkind JS, Hancock WS. Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry. Oral Oncol. 2005 Feb; 41(2):183-99. PMID: 15695121.
        View in: PubMed
      122. Vitale-Cross L, Amornphimoltham P, Fisher G, Molinolo A, Gutkind JS. Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis. Cancer Res. 2004 Dec 15; 64(24):8804-7. PMID: 15604235.
        View in: PubMed
      123. Curino A, Patel V, Nielsen BS, Iskander AJ, Ensley JF, Yoo GH, Holsinger FC, Myers JN, El-Nagaar A, Kellman RM, Shillitoe EJ, Molinolo A, Gutkind JS, Bugge TH. Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography. Oral Oncol. 2004 Nov; 40(10):1026-32. PMID: 15509494.
        View in: PubMed
      124. Sriuranpong V, Mutirangura A, Gillespie JW, Patel V, Amornphimoltham P, Molinolo A, Kerekhanjanarong V, Supanakorn S, Supiyaphun P, Rangdaeng S, Voravud N, Gutkind JS. Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays. Clin Cancer Res. 2004 Aug 1; 10(15):4944-58. PMID: 15297395.
        View in: PubMed
      125. Salatino M, Schillaci R, Proietti CJ, Carnevale R, Frahm I, Molinolo A, Iribarren A, Charreau EH, Elizalde PV. Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity. Oncogene. 2004 Jul 1; 23(30):5161-74. PMID: 15122317.
        View in: PubMed
      126. Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J, Sausville EA, Molinolo A, Gutkind JS. Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res. 2004 Jun 15; 10(12 Pt 1):4029-37. PMID: 15217935.
        View in: PubMed
      127. Efeyan A, Fabris V, Merani S, Lanari C, Molinolo A. Establishment of two hormone-responsive mouse mammary carcinoma cell lines derived from a metastatic mammary tumor. Breast Cancer Res Treat. 2004 Feb; 83(3):233-44. PMID: 14758093.
        View in: PubMed
      128. Helguero LA, Viegas M, Asaithamby A, Shyamala G, Lanari C, Molinolo A. Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment. Breast Cancer Res Treat. 2003 Jun; 79(3):379-90. PMID: 12846422.
        View in: PubMed
      129. Lamb CA, Helguero LA, Fabris V, Lucas C, Molinolo A, Lanari C. Differential effects of raloxifene, tamoxifen and fulvestrant on a murine mammary carcinoma. Breast Cancer Res Treat. 2003 May; 79(1):25-35. PMID: 12779079.
        View in: PubMed
      130. Helguero LA, Lamb C, Molinolo A, Lanari C. Evidence for two progesterone receptor binding sites in murine mammary carcinomas. J Steroid Biochem Mol Biol. 2003 Jan; 84(1):9-14. PMID: 12648519.
        View in: PubMed
      131. Montaner S, Sodhi A, Molinolo A, Bugge TH, Sawai ET, He Y, Li Y, Ray PE, Gutkind JS. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell. 2003 Jan; 3(1):23-36. PMID: 12559173.
        View in: PubMed
      132. Lanari C, Molinolo A. Progesterone receptors--animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer. Breast Cancer Res. 2002; 4(6):240-3. PMID: 12473170.
        View in: PubMed
      133. Vanzulli S, Efeyan A, Benavides F, Helguero LA, Peters G, Shen J, Conti CJ, Lanari C, Molinolo A. p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas. Carcinogenesis. 2002 May; 23(5):749-58. PMID: 12016147.
        View in: PubMed
      134. Vermeulen M, Pazos P, Lanari C, Molinolo A, Gamberale R, Geffner JR, Giordano M. Medroxyprogesterone acetate enhances in vivo and in vitro antibody production. Immunology. 2001 Sep; 104(1):80-6. PMID: 11576224.
        View in: PubMed
      135. Pazos P, Lanari C, Molinolo A. Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice. Leuk Res. 2001 Feb; 25(2):165-7. PMID: 11166832.
        View in: PubMed
      136. Lanari C, Lüthy I, Lamb CA, Fabris V, Pagano E, Helguero LA, Sanjuan N, Merani S, Molinolo A. Five novel hormone-responsive cell lines derived from murine mammary ductal carcinomas: in vivo and in vitro effects of estrogens and progestins. Cancer Res. 2001 Jan 1; 61(1):293-302. PMID: 11196177.
        View in: PubMed
      137. Lamb C, Simian M, Molinolo A, Pazos P, Lanari C. Regulation of cell growth of a progestin-dependent murine mammary carcinoma in vitro: progesterone receptor involvement in serum or growth factor-induced cell proliferation. J Steroid Biochem Mol Biol. 1999 Sep-Oct; 70(4-6):133-42. PMID: 10622401.
        View in: PubMed
      138. Montecchia MF, Molinolo A, Lanari C. Reversal of estrogen-resistance in murine mammary adenocarcinomas. Breast Cancer Res Treat. 1999 Mar; 54(2):93-9. PMID: 10424399.
        View in: PubMed
      139. Montecchia MF, Lamb C, Molinolo A, Luthy IA, Pazos P, Charreau E, Vanzulli S, Lanari C. Progesterone receptor involvement in independent tumor growth in MPA-induced murine mammary adenocarcinomas. J Steroid Biochem Mol Biol. 1999 Jan; 68(1-2):11-21. PMID: 10215033.
        View in: PubMed
      140. Elizalde PV, Lanari C, Molinolo A, Guerra FK, Balañá ME, Simian M, Iribarren AM, Charreau EH. Involvement of insulin-like growth factors-I and -II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas. J Steroid Biochem Mol Biol. 1998 Nov; 67(4):305-17. PMID: 9883987.
        View in: PubMed
      141. Molinolo A, Simian M, Vanzulli S, Pazos P, Lamb C, Montecchia F, Lanari C. Involvement of EGF in medroxyprogesterone acetate (MPA)-induced mammary gland hyperplasia and its role in MPA-induced mammary tumors in BALB/c mice. Cancer Lett. 1998 Apr 10; 126(1):49-57. PMID: 9563648.
        View in: PubMed
      142. Pazos P, Lanari C, Elizalde P, Montecchia F, Charreau EH, Molinolo A. Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice. Carcinogenesis. 1998 Mar; 19(3):529-31. PMID: 9525291.
        View in: PubMed
      143. Lanari C, Montecchia MF, Pazos P, Simian M, Vanzulli S, Lamb C, Molinolo A. [Progestin-induced mammary adenocarcinomas in BALB/c mice. Progression from hormone-dependent to autonomous tumors]. Medicina (B Aires). 1997; 57 Suppl 2:55-69. PMID: 9567344.
        View in: PubMed
      144. Dran G, Luthy IA, Molinolo A, Montecchia F, Charreau EH, Pasqualini CD, Lanari C. Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma. Breast Cancer Res Treat. 1995 Aug; 35(2):173-86. PMID: 7647339.
        View in: PubMed
      145. Roselli M, Hitchcock CL, Molinolo A, Milenic DE, Colcher D, Martin EW, Hinkle GH, Schlom J. Autoradiographic evaluation of radiolabeled monoclonal antibody B72.3 distribution in tumor and lymph nodes of adenocarcinoma patients. Anticancer Res. 1995 May-Jun; 15(3):975-84. PMID: 7645989.
        View in: PubMed
      146. Kordon EC, Guerra F, Molinolo A, Elizalde P, Charreau EH, Pasqualini CD, Montecchia F, Pazos P, Dran G, Lanari C. Effect of sialoadenectomy on medroxyprogesterone-acetate-induced mammary carcinogenesis in BALB/c mice. Correlation between histology and epidermal-growth-factor receptor content. Int J Cancer. 1994 Oct 15; 59(2):196-203. PMID: 7927919.
        View in: PubMed
      147. Kordon EC, Molinolo A, Pasqualini CD, Charreau EH, Pazos P, Dran G, Lanari C. Progesterone induction of mammary carcinomas in BALB/c female mice. Correlation between progestin dependence and morphology. Breast Cancer Res Treat. 1993 Oct; 28(1):29-39. PMID: 8123867.
        View in: PubMed
      148. Lanari C, Molinolo A, Pasqualini CD. Re: Oral contraceptives and breast cancer. J Natl Cancer Inst. 1993 Sep 15; 85(18):1525. PMID: 8360937.
        View in: PubMed
      149. Lanari C, Molinolo A, Dosne Pasqualini C. [Progesterone and breast cancer]. Medicina (B Aires). 1993; 53(3):276-7. PMID: 8114637.
        View in: PubMed
      150. Greiner JW, Guadagni F, Goldstein D, Smalley RV, Borden EC, Simpson JF, Molinolo A, Schlom J. Intraperitoneal administration of interferon-gamma to carcinoma patients enhances expression of tumor-associated glycoprotein-72 and carcinoembryonic antigen on malignant ascites cells. J Clin Oncol. 1992 May; 10(5):735-46. PMID: 1569446.
        View in: PubMed
      151. Schlom J, Eggensperger D, Colcher D, Molinolo A, Houchens D, Miller LS, Hinkle G, Siler K. Therapeutic advantage of high-affinity anticarcinoma radioimmunoconjugates. Cancer Res. 1992 Mar 1; 52(5):1067-72. PMID: 1310638.
        View in: PubMed
      152. Kordon E, Lanari C, Molinolo A, Elizalde PV, Charreau EH, Dosne Pasqualini C. Estrogen inhibition of MPA-induced mouse mammary tumor transplants. Int J Cancer. 1991 Dec 2; 49(6):900-5. PMID: 1835715.
        View in: PubMed
      153. Lanari C, Molinolo A, Kordon E, Pasualini CD, Charreau EH. Progesterone receptors in estrogen-induced fibromatosis of guinea pigs. Cancer Lett. 1990 Jun 15; 51(3):235-45. PMID: 2350763.
        View in: PubMed
      154. Schlom J, Molinolo A, Simpson JF, Siler K, Roselli M, Hinkle G, Houchens DP, Colcher D. Advantage of dose fractionation in monoclonal antibody-targeted radioimmunotherapy. J Natl Cancer Inst. 1990 May 2; 82(9):763-71. PMID: 2182892.
        View in: PubMed
      155. Molinolo A, Simpson JF, Thor A, Schlom J. Enhanced tumor binding using immunohistochemical analyses by second generation anti-tumor-associated glycoprotein 72 monoclonal antibodies versus monoclonal antibody B72.3 in human tissue. Cancer Res. 1990 Feb 15; 50(4):1291-8. PMID: 2297774.
        View in: PubMed
      156. Lanari C, Kordon E, Molinolo A, Pasqualini CD, Charreau EH. Mammary adenocarcinomas induced by medroxyprogesterone acetate: hormone dependence and EGF receptors of BALB/c in vivo sublines. Int J Cancer. 1989 May 15; 43(5):845-50. PMID: 2523869.
        View in: PubMed
      157. Shrivastav S, Schlom J, Raubitschek A, Molinolo A, Simpson J, Hand PH. Studies concerning the effect of external irradiation on localization of radiolabeled monoclonal antibody B72.3 to human colon carcinoma xenografts. Int J Radiat Oncol Biol Phys. 1989 Mar; 16(3):721-9. PMID: 2921170.
        View in: PubMed
      158. Muraro R, Kuroki M, Wunderlich D, Poole DJ, Colcher D, Thor A, Greiner JW, Simpson JF, Molinolo A, Noguchi P. Generation and characterization of B72.3 second generation monoclonal antibodies reactive with the tumor-associated glycoprotein 72 antigen. Cancer Res. 1988 Aug 15; 48(16):4588-96. PMID: 3396010.
        View in: PubMed
      159. Molinolo A, Lanari C, Charreau EH, Sanjuan N, Pasqualini CD. Mouse mammary tumors induced by medroxyprogesterone acetate: immunohistochemistry and hormonal receptors. J Natl Cancer Inst. 1987 Dec; 79(6):1341-50. PMID: 2826865.
        View in: PubMed
      160. Lanari C, Molinolo A, Pasqualini CD. Induction of mammary adenocarcinomas by medroxyprogesterone acetate in BALB/c female mice. Cancer Lett. 1986 Nov; 33(2):215-23. PMID: 2947675.
        View in: PubMed
      161. Lanari C, Molinolo A, Pasqualini CD. Inhibitory effect of medroxyprogesterone acetate on foreign body tumorigenesis in mice. J Natl Cancer Inst. 1986 Jul; 77(1):157-64. PMID: 3522997.
        View in: PubMed
      162. Molinolo A, Meiss RP, Leo P, Sens AI. Demonstration of cytokeratins by immunoperoxidase staining in prostatic tissue. J Urol. 1985 Nov; 134(5):1037-40. PMID: 2414467.
        View in: PubMed
      163. Jufe R, Molinolo A, Fefer SA, Meiss RP. Plasma cell granuloma of the bladder: a case report. J Urol. 1984 Jun; 131(6):1175-6. PMID: 6726924.
        View in: PubMed