UCSD Profiles
search, discover, network
Powered by Altman Clinical and
Translational Research Institute
Search
About
Help / Contact Us
Sign in
to edit your profile (add interests, mentoring, photo, etc.)
Menu
Find People
Find Everything
About This Site
Login to Profiles
Alexandr Kornev
Title
Project Scientist
School
University of California, San Diego
Department
Pharmacology
Address
9500 Gilman Drive #0654
CA La Jolla 92093
Phone
858-534-8190
vCard
Download vCard
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
login
to make corrections and additions, or
contact us for help
.
List All
|
Timeline
Publications by year:
View visualization as text
Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL,
Kornev A
, Taylor SS, Veglia G. A dynamic hydrophobic core orchestrates allostery in protein kinases. Sci Adv. 2017 Apr; 3(4):e1600663. PMID: 28435869.
View in:
PubMed
P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC,
Kornev A
, Taylor SS, Amaro RE. Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIa. Biochemistry. 2017 Mar 14; 56(10):1536-1545. PMID: 28221775.
View in:
PubMed
Kornev A
, Taylor SS. Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci. 2015 Nov; 40(11):628-47. PMID: 26481499; PMCID: PMC4630092 [Available on 11/01/16].
View in:
PubMed
,
PubMed Central
Antal CE, Callender JA,
Kornev A
, Taylor SS, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C ßII. Cell Rep. 2015 Aug 25; 12(8):1252-60. PMID: 26279568; PMCID: PMC4551583.
View in:
PubMed
,
PubMed Central
Zhang P, Ye F, Bastidas AC,
Kornev A
, Wu J, Ginsberg MH, Taylor SS. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 01; 23(9):1563-72. PMID: 26278174; PMCID: PMC4558360.
View in:
PubMed
,
PubMed Central
Malmstrom RD,
Kornev A
, Taylor SS, Amaro RE. Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nat Commun. 2015 Jul 06; 6:7588. PMID: 26145448; PMCID: PMC4504738.
View in:
PubMed
,
PubMed Central
Zhang P,
Kornev A
, Wu J, Taylor SS. Discovery of Allostery in PKA Signaling. Biophys Rev. 2015 Jun 01; 7(2):227-238. PMID: 26097522.
View in:
PubMed
Taylor SS, Shaw AS, Kannan N,
Kornev A
. Integration of signaling in the kinome: Architecture and regulation of the aC Helix. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1567-74. PMID: 25891902; PMCID: PMC4577442 [Available on 10/01/16].
View in:
PubMed
,
PubMed Central
Hu J, Ahuja LG, Meharena HS, Kannan N,
Kornev A
, Taylor SS, Shaw AS. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015 Jan; 35(1):264-76. PMID: 25348715; PMCID: PMC4295384.
View in:
PubMed
,
PubMed Central
McClendon CL,
Kornev A
, Gilson MK, Taylor SS. Dynamic architecture of a protein kinase. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4623-31. PMID: 25319261; PMCID: PMC4217441.
View in:
PubMed
,
PubMed Central
Boras BW,
Kornev A
, Taylor SS, McCulloch AD. Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIa activation in response to cAMP binding. J Biol Chem. 2014 Oct 24; 289(43):30040-51. PMID: 25202018; PMCID: PMC4208011.
View in:
PubMed
,
PubMed Central
Shaw AS,
Kornev A
, Hu J, Ahuja LG, Taylor SS. Kinases and pseudokinases: lessons from RAF. Mol Cell Biol. 2014 May; 34(9):1538-46. PMID: 24567368; PMCID: PMC3993607.
View in:
PubMed
,
PubMed Central
Bruystens JG, Wu J, Fortezzo A,
Kornev A
, Blumenthal DK, Taylor SS. PKA RIa homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure. 2014 Jan 07; 22(1):59-69. PMID: 24316401; PMCID: PMC3963464.
View in:
PubMed
,
PubMed Central
Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor SS,
Kornev A
. Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol. 2013 Oct; 11(10):e1001680. PMID: 24143133; PMCID: PMC3797032.
View in:
PubMed
,
PubMed Central
Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ,
Kornev A
, Taylor SS, Shaw AS. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 2013 Aug 29; 154(5):1036-46. PMID: 23993095; PMCID: PMC3844432.
View in:
PubMed
,
PubMed Central
Taylor SS, Shaw A, Hu J, Meharena HS,
Kornev A
. Pseudokinases from a structural perspective. Biochem Soc Trans. 2013 Aug; 41(4):981-6. PMID: 23863167; PMCID: PMC4399968.
View in:
PubMed
,
PubMed Central
Taylor SS, Zhang P, Steichen JM, Keshwani MM,
Kornev A
. PKA: lessons learned after twenty years. Biochim Biophys Acta. 2013 Jul; 1834(7):1271-8. PMID: 23535202; PMCID: PMC3763834.
View in:
PubMed
,
PubMed Central
Taylor SS, Ilouz R, Zhang P,
Kornev A
. Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol. 2012 Oct; 13(10):646-58. PMID: 22992589; PMCID: PMC3985763.
View in:
PubMed
,
PubMed Central
Taylor SS, Keshwani MM, Steichen JM,
Kornev A
. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2517-28. PMID: 22889904; PMCID: PMC3415842.
View in:
PubMed
,
PubMed Central
Ilouz R, Bubis J, Wu J, Yim YY, Deal MS,
Kornev A
, Ma Y, Blumenthal DK, Taylor SS. Localization and quaternary structure of the PKA RIß holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12443-8. PMID: 22797896; PMCID: PMC3411989.
View in:
PubMed
,
PubMed Central
Keshwani MM, Klammt C, von Daake S, Ma Y,
Kornev A
, Choe S, Insel PA, Taylor SS. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1221-9. PMID: 22493239; PMCID: PMC3356610.
View in:
PubMed
,
PubMed Central
Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS,
Kornev A
, Taylor SS. Structure and allostery of the PKA RIIß tetrameric holoenzyme. Science. 2012 Feb 10; 335(6069):712-6. PMID: 22323819; PMCID: PMC3985767.
View in:
PubMed
,
PubMed Central
Yang J, Wu J, Steichen JM,
Kornev A
, Deal MS, Li S, Sankaran B, Woods VL, Taylor SS. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol. 2012 Jan 27; 415(4):666-79. PMID: 22138346; PMCID: PMC3445030.
View in:
PubMed
,
PubMed Central
Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL,
Kornev A
, Taylor SS, Dostmann WR. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure. 2011 Sep 07; 19(9):1317-27. PMID: 21893290; PMCID: PMC3168983.
View in:
PubMed
,
PubMed Central
Hu J, Yu H,
Kornev A
, Zhao J, Filbert EL, Taylor SS, Shaw AS. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6067-72. PMID: 21441104; PMCID: PMC3076888.
View in:
PubMed
,
PubMed Central
Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA,
Kornev A
, Taylor SS. Realizing the allosteric potential of the tetrameric protein kinase A RIa holoenzyme. Structure. 2011 Feb 09; 19(2):265-76. PMID: 21300294; PMCID: PMC3097484.
View in:
PubMed
,
PubMed Central
Taylor SS,
Kornev A
. Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci. 2011 Feb; 36(2):65-77. PMID: 20971646; PMCID: PMC3084033.
View in:
PubMed
,
PubMed Central
Masterson LR, Cheng C, Yu T, Tonelli M,
Kornev A
, Taylor SS, Veglia G. Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol. 2010 Nov; 6(11):821-8. PMID: 20890288; PMCID: PMC3487389.
View in:
PubMed
,
PubMed Central
Sjoberg TJ,
Kornev A
, Taylor SS. Dissecting the cAMP-inducible allosteric switch in protein kinase A RIalpha. Protein Sci. 2010 Jun; 19(6):1213-21. PMID: 20512974; PMCID: PMC2895245.
View in:
PubMed
,
PubMed Central
Taylor SS,
Kornev A
. Yet another "active" pseudokinase, Erb3. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8047-8. PMID: 20421461; PMCID: PMC2889589.
View in:
PubMed
,
PubMed Central
Anand GS, Krishnamurthy S, Bishnoi T,
Kornev A
, Taylor SS, Johnson DA. Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. Mol Cell Proteomics. 2010 Oct; 9(10):2225-37. PMID: 20167947; PMCID: PMC2957725.
View in:
PubMed
,
PubMed Central
Kornev A
, Taylor SS. Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta. 2010 Mar; 1804(3):440-4. PMID: 19879387; PMCID: PMC3435107.
View in:
PubMed
,
PubMed Central
Thompson EE,
Kornev A
, Kannan N, Kim C, Ten Eyck LF, Taylor SS. Comparative surface geometry of the protein kinase family. Protein Sci. 2009 Oct; 18(10):2016-26. PMID: 19610074; PMCID: PMC2786965.
View in:
PubMed
,
PubMed Central
Romano RA, Kannan N,
Kornev A
, Allison CJ, Taylor SS. A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1. Protein Sci. 2009 Jul; 18(7):1486-97. PMID: 19530248; PMCID: PMC2775216.
View in:
PubMed
,
PubMed Central
Kornev A
, Taylor SS. Pseudokinases: functional insights gleaned from structure. Structure. 2009 Jan 14; 17(1):5-7. PMID: 19141276.
View in:
PubMed
Kornev A
, Taylor SS, Ten Eyck LF. A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14377-82. PMID: 18787129; PMCID: PMC2533684.
View in:
PubMed
,
PubMed Central
Kornev A
, Taylor SS, Ten Eyck LF. A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. PLoS Comput Biol. 2008 Apr 11; 4(4):e1000056. PMID: 18404204; PMCID: PMC2275311.
View in:
PubMed
,
PubMed Central
Ten Eyck LF, Taylor SS,
Kornev A
. Conserved spatial patterns across the protein kinase family. Biochim Biophys Acta. 2008 Jan; 1784(1):238-43. PMID: 18067871.
View in:
PubMed
Kornev A
, Haste NM, Taylor SS, Eyck LF. Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17783-8. PMID: 17095602; PMCID: PMC1693824.
View in:
PubMed
,
PubMed Central
Berman HM, Ten Eyck LF, Goodsell DS, Haste NM,
Kornev A
, Taylor SS. The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):45-50. PMID: 15618393; PMCID: PMC544069.
View in:
PubMed
,
PubMed Central
Lebedev VS,
Kornev A
, Fedorov IuI. [The effect of surface and membrane potential on 1-anilino-8-naphthalenesulfonate binding with E. coli membrane]. Biofizika. 1988 Sep-Oct; 33(5):800-3. PMID: 3066405.
View in:
PubMed
Lebedev VS, Kuzovnikova TA,
Kornev A
, Fedorov IuI. [Characteristics of copper-induced streptomycin transport in Escherichia coli]. Biofizika. 1987 Jul-Aug; 32(4):638-41. PMID: 3311169.
View in:
PubMed
View timeline visualization
Year
Publications
1987
1
1988
1
2004
1
2006
1
2007
1
2008
2
2009
4
2010
5
2011
4
2012
5
2013
5
2014
4
2015
6
2017
2
Alexandr's Networks
Concepts
Derived automatically from this person's publications.
Cyclic AMP-Dependent Protein Kinases
Protein Kinases
Models, Molecular
Cyclic AMP
Eukaryota
See all (142) concept(s)
_
Co-Authors
People in Profiles who have published with this person.
Newton, Alexandra
Ilouz, Ronit
Amaro, Rommie
Taylor, Susan
Ten Eyck, Lynn
See all (12) people
_
Similar People
People who share similar concepts with this person.
Guan, Kun-liang
Godzik, Adam
Mccammon, J. Andrew
Saier, Milton
Taylor, Susan
See all (60) people
_
Same Department
Chun, Jerold
Leffert, Hyam
Michkov, Alexander
Spinler, Kyle
Wu, Meilin
Search Department
Physical Neighbors
People whose addresses are nearby this person.
Lawson, Mark
Schangali, Amir
Lopez Ramirez, Miguel
Dhar, Debanjan
Chiang, Wei-chieh
_