Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Alexander Groisman

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPhysics
    Address9500 Gilman Drive #0374
    CA La Jolla 92093
    Phone858-822-1838
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      CHEMOTAXIS IN DICTYOSTELIUM DISCOIDEUM: AN INTEGRATIVE APPROACH
      NIH P01GM078586Jul 1, 2006 - Jul 31, 2017
      Role: Co-Investigator
      Cell Adhesion Mechanisms in Vascular Disease & Thrombosis
      NIH/NHLBI P01HL078784Dec 1, 2004 - Apr 30, 2020
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Paulick A, Jakovljevic V, Zhang S, Erickstad M, Groisman A, Meir Y, Ryu WS, Wingreen NS, Sourjik V. Mechanism of bidirectional thermotaxis in Escherichia coli. Elife. 2017 Aug 03; 6. PMID: 28826491.
        View in: PubMed
      2. Costigliola N, Ding L, Burckhardt CJ, Han SJ, Gutierrez E, Mota A, Groisman A, Mitchison TJ, Danuser G. Vimentin fibers orient traction stress. Proc Natl Acad Sci U S A. 2017 May 16; 114(20):5195-5200. PMID: 28465431.
        View in: PubMed
      3. Weijts B, Tkachenko E, Traver D, Groisman A. A Four-Well Dish for High-Resolution Longitudinal Imaging of the Tail and Posterior Trunk of Larval Zebrafish. Zebrafish. 2017 Jan 24. PMID: 28118101.
        View in: PubMed
      4. Cremer J, Segota I, Yang CY, Arnoldini M, Sauls JT, Zhang Z, Gutierrez E, Groisman A, Hwa T. Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel. Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41):11414-11419. PMID: 27681630.
        View in: PubMed
      5. Vertelov G, Gutierrez E, Lee SA, Ronan E, Groisman A, Tkachenko E. Rigidity of silicone substrates controls cell spreading and stem cell differentiation. Sci Rep. 2016; 6:33411. PMID: 27651230.
        View in: PubMed
      6. Fan Z, McArdle S, Marki A, Mikulski Z, Gutierrez E, Engelhardt B, Deutsch U, Ginsberg M, Groisman A, Ley K. Neutrophil recruitment limited by high-affinity bent ß2 integrin binding ligand in cis. Nat Commun. 2016; 7:12658. PMID: 27578049.
        View in: PubMed
      7. Marki A, Gutierrez E, Mikulski Z, Groisman A, Ley K. Microfluidics-based side view flow chamber reveals tether-to-sling transition in rolling neutrophils. Sci Rep. 2016; 6:28870. PMID: 27357741.
        View in: PubMed
      8. Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver VM. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integr Biol (Camb). 2016 Jul 11; 8(7):795-804. PMID: 27334548.
        View in: PubMed
      9. Kuwano Y, Adler M, Zhang H, Groisman A, Ley K. Gai2 and Gai3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils. J Immunol. 2016 May 1; 196(9):3828-33. PMID: 26976957.
        View in: PubMed
      10. Lee K, Elliott HL, Oak Y, Zee CT, Groisman A, Tytell JD, Danuser G. Functional hierarchy of redundant actin assembly factors revealed by fine-grained registration of intrinsic image fluctuations. Cell Syst. 2015 Jul 29; 1(1):37-50. PMID: 26273703.
        View in: PubMed
      11. Bober BG, Gutierrez E, Plaxe S, Groisman A, Shah SB. Combinatorial influences of paclitaxel and strain on axonal transport. Exp Neurol. 2015 Sep; 271:358-67. PMID: 26143110.
        View in: PubMed
      12. Han SJ, Oak Y, Groisman A, Danuser G. Traction microscopy to identify force modulation in subresolution adhesions. Nat Methods. 2015 Jul; 12(7):653-6. PMID: 26030446.
        View in: PubMed
      13. Erickstad M, Hale LA, Chalasani SH, Groisman A. A microfluidic system for studying the behavior of zebrafish larvae under acute hypoxia. Lab Chip. 2015 Jan 22; 15(3):857-66. PMID: 25490410.
        View in: PubMed
      14. Polinkovsky ME, Gambin Y, Banerjee PR, Erickstad MJ, Groisman A, Deniz AA. Ultrafast cooling reveals microsecond-scale biomolecular dynamics. Nat Commun. 2014; 5:5737. PMID: 25517430.
        View in: PubMed
      15. Erickstad M, Gutierrez E, Groisman A. A low-cost low-maintenance ultraviolet lithography light source based on light-emitting diodes. Lab Chip. 2014 Dec 3; 15(1):57-61. PMID: 25322205.
        View in: PubMed
      16. Skoge M, Yue H, Erickstad M, Bae A, Levine H, Groisman A, Loomis WF, Rappel WJ. Cellular memory in eukaryotic chemotaxis. Proc Natl Acad Sci U S A. 2014 Oct 7; 111(40):14448-53. PMID: 25249632.
        View in: PubMed
      17. Manthey CF, Calabio CB, Wosinski A, Hanson EM, Vallance BA, Groisman A, Martín MG, Wang JY, Eckmann L. Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions. Am J Physiol Cell Physiol. 2014 Jul 15; 307(2):C180-9. PMID: 24848114.
        View in: PubMed
      18. Deris JB, Kim M, Zhang Z, Okano H, Hermsen R, Groisman A, Hwa T. The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria. Science. 2013 Nov 29; 342(6162):1237435. PMID: 24288338; NIHMSID: NIHMS587924.
        View in: PubMed
      19. Tkachenko E, Gutierrez E, Saikin SK, Fogelstrand P, Kim C, Groisman A, Ginsberg MH. The nucleus of endothelial cell as a sensor of blood flow direction. Biol Open. 2013; 2(10):1007-12. PMID: 24167710.
        View in: PubMed
      20. Adler M, Erickstad M, Gutierrez E, Groisman A. Studies of bacterial aerotaxis in a microfluidic device. Lab Chip. 2012 Nov 21; 12(22):4835-47. PMID: 23010909; NIHMSID: NIHMS416705.
        View in: PubMed
      21. Razooky BS, Gutierrez E, Terry VH, Spina CA, Groisman A, Weinberger LS. Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes. Lab Chip. 2012 Nov 7; 12(21):4305-12. PMID: 22976503.
        View in: PubMed
      22. Loomis WF, Fuller D, Gutierrez E, Groisman A, Rappel WJ. Innate non-specific cell substratum adhesion. PLoS One. 2012; 7(8):e42033. PMID: 22952588.
        View in: PubMed
      23. Sundd P, Gutierrez E, Koltsova EK, Kuwano Y, Fukuda S, Pospieszalska MK, Groisman A, Ley K. 'Slings' enable neutrophil rolling at high shear. Nature. 2012 Aug 16; 488(7411):399-403. PMID: 22763437.
        View in: PubMed
      24. Adler M, Groisman A. Linear conversion of pressure into concentration, rapid switching of concentration, and generation of linear ramps of concentration in a microfluidic device. Biomicrofluidics. 2012 Jun; 6(2):24109-2410916. PMID: 22550555; PMCID: PMC3338547.
      25. Takeda K, Shao D, Adler M, Charest PG, Loomis WF, Levine H, Groisman A, Rappel WJ, Firtel RA. Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway. Sci Signal. 2012 Jan 3; 5(205):ra2. PMID: 22215733.
        View in: PubMed
      26. Kim M, Zhang Z, Okano H, Yan D, Groisman A, Hwa T. Need-based activation of ammonium uptake in Escherichia coli. Mol Syst Biol. 2012; 8:616. PMID: 23010999; PMCID: PMC3472687.
      27. Gutierrez E, Groisman A. Measurements of elastic moduli of silicone gel substrates with a microfluidic device. PLoS One. 2011; 6(9):e25534. PMID: 21980487; PMCID: PMC3184124.
      28. Gutierrez E, Tkachenko E, Besser A, Sundd P, Ley K, Danuser G, Ginsberg MH, Groisman A. High refractive index silicone gels for simultaneous total internal reflection fluorescence and traction force microscopy of adherent cells. PLoS One. 2011; 6(9):e23807. PMID: 21961031.
        View in: PubMed
      29. Carvalho A, Olson SK, Gutierrez E, Zhang K, Noble LB, Zanin E, Desai A, Groisman A, Oegema K. Acute drug treatment in the early C. elegans embryo. PLoS One. 2011; 6(9):e24656. PMID: 21935434.
        View in: PubMed
      30. Sundd P, Gutierrez E, Petrich BG, Ginsberg MH, Groisman A, Ley K. Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting. Microcirculation. 2011 Jul; 18(5):361-72. PMID: 21418380.
        View in: PubMed
      31. Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH. Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol. 2011 Jun; 13(6):660-7. PMID: 21572420.
        View in: PubMed
      32. Gambin Y, VanDelinder V, Ferreon AC, Lemke EA, Groisman A, Deniz AA. Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing. Nat Methods. 2011 Mar; 8(3):239-41. PMID: 21297620; NIHMSID: NIHMS264963.
        View in: PubMed
      33. Mitsios JV, Prevost N, Kasirer-Friede A, Gutierrez E, Groisman A, Abrams CS, Wang Y, Litvinov RI, Zemljic-Harpf A, Ross RS, Shattil SJ. What is vinculin needed for in platelets? J Thromb Haemost. 2010 Oct; 8(10):2294-304. PMID: 20670372.
        View in: PubMed
      34. Skoge M, Adler M, Groisman A, Levine H, Loomis WF, Rappel WJ. Gradient sensing in defined chemotactic fields. Integr Biol (Camb). 2010 Nov; 2(11-12):659-68. PMID: 20882228.
        View in: PubMed
      35. Fuller D, Chen W, Adler M, Groisman A, Levine H, Rappel WJ, Loomis WF. External and internal constraints on eukaryotic chemotaxis. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9656-9. PMID: 20457897.
        View in: PubMed
      36. Gambin Y, Simonnet C, VanDelinder V, Deniz A, Groisman A. Ultrafast microfluidic mixer with three-dimensional flow focusing for studies of biochemical kinetics. Lab Chip. 2010 Mar 7; 10(5):598-609. PMID: 20162235.
        View in: PubMed
      37. Adler M, Polinkovsky M, Gutierrez E, Groisman A. Generation of oxygen gradients with arbitrary shapes in a microfluidic device. Lab Chip. 2010 Feb 7; 10(3):388-91. PMID: 20091013; NIHMSID: NIHMS207353.
        View in: PubMed
      38. Lemke EA, Gambin Y, Vandelinder V, Brustad EM, Liu HW, Schultz PG, Groisman A, Deniz AA. Microfluidic device for single-molecule experiments with enhanced photostability. J Am Chem Soc. 2009 Sep 30; 131(38):13610-2. PMID: 19772358; NIHMSID: NIHMS144571.
        View in: PubMed
      39. Vandelinder V, Ferreon AC, Gambin Y, Deniz AA, Groisman A. High-resolution temperature-concentration diagram of alpha-synuclein conformation obtained from a single Förster resonance energy transfer image in a microfluidic device. Anal Chem. 2009 Aug 15; 81(16):6929-35. PMID: 19555081; NIHMSID: NIHMS132547.
        View in: PubMed
      40. Polinkovsky M, Gutierrez E, Levchenko A, Groisman A. Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures. Lab Chip. 2009 Apr 21; 9(8):1073-84. PMID: 19350089.
        View in: PubMed
      41. Tkachenko E, Gutierrez E, Ginsberg MH, Groisman A. An easy to assemble microfluidic perfusion device with a magnetic clamp. Lab Chip. 2009 Apr 21; 9(8):1085-95. PMID: 19350090.
        View in: PubMed
      42. Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, Groisman A, Zhang J, Ginsberg MH. Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell. 2008 Nov; 19(11):4930-41. PMID: 18784251.
        View in: PubMed
      43. Latz MI, Bovard M, VanDelinder V, Segre E, Rohr J, Groisman A. Bioluminescent response of individual dinoflagellate cells to hydrodynamic stress measured with millisecond resolution in a microfluidic device. J Exp Biol. 2008 Sep; 211(Pt 17):2865-75. PMID: 18723546.
        View in: PubMed
      44. Groisman A, Zamek S, Campbell K, Pang L, Levy U, Fainman Y. Optofluidic 1x4 switch. Opt Express. 2008 Sep 1; 16(18):13499-508. PMID: 18772958.
        View in: PubMed
      45. Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A. Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip. 2008 Sep; 8(9):1486-95. PMID: 18818803.
        View in: PubMed
      46. Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH. Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circ Res. 2008 Jul 18; 103(2):177-85. PMID: 18583710.
        View in: PubMed
      47. Shefi O, Simonnet C, Groisman A, Macagno ER. Localized RNAi and ectopic gene expression in the medicinal leech. J Vis Exp. 2008; (14). PMID: 19066579.
        View in: PubMed
      48. Cho H, Jönsson H, Campbell K, Melke P, Williams JW, Jedynak B, Stevens AM, Groisman A, Levchenko A. Self-organization in high-density bacterial colonies: efficient crowd control. PLoS Biol. 2007 Oct 30; 5(11):e302. PMID: 18044986; PMCID: PMC2043048.
      49. Herzmark P, Campbell K, Wang F, Wong K, El-Samad H, Groisman A, Bourne HR. Bound attractant at the leading vs. the trailing edge determines chemotactic prowess. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13349-54. PMID: 17684096; PMCID: PMC1940227.
      50. Paliwal S, Iglesias PA, Campbell K, Hilioti Z, Groisman A, Levchenko A. MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature. 2007 Mar 1; 446(7131):46-51. PMID: 17310144.
        View in: PubMed
      51. Gutierrez E, Groisman A. Quantitative measurements of the strength of adhesion of human neutrophils to a substratum in a microfluidic device. Anal Chem. 2007 Mar 15; 79(6):2249-58. PMID: 17305308.
        View in: PubMed
      52. VanDelinder V, Groisman A. Perfusion in microfluidic cross-flow: separation of white blood cells from whole blood and exchange of medium in a continuous flow. Anal Chem. 2007 Mar 1; 79(5):2023-30. PMID: 17249639.
        View in: PubMed
      53. Campbell K, Groisman A. Generation of complex concentration profiles in microchannels in a logarithmically small number of steps. Lab Chip. 2007 Feb; 7(2):264-72. PMID: 17268630.
        View in: PubMed
      54. Simonnet C, Groisman A. High-throughput and high-resolution flow cytometry in molded microfluidic devices. Anal Chem. 2006 Aug 15; 78(16):5653-63. PMID: 16906708.
        View in: PubMed
      55. Shefi O, Simonnet C, Baker MW, Glass JR, Macagno ER, Groisman A. Microtargeted gene silencing and ectopic expression in live embryos using biolistic delivery with a pneumatic capillary gun. J Neurosci. 2006 Jun 7; 26(23):6119-23. PMID: 16763019.
        View in: PubMed
      56. VanDelinder V, Groisman A. Separation of plasma from whole human blood in a continuous cross-flow in a molded microfluidic device. Anal Chem. 2006 Jun 1; 78(11):3765-71. PMID: 16737235.
        View in: PubMed
      57. Pang L, Levy U, Campbell K, Groisman A, Fainman Y. Set of two orthogonal adaptive cylindrical lenses in a monolith elastomer device. Opt Express. 2005 Oct 31; 13(22):9003-13. PMID: 19498935.
        View in: PubMed
      58. Groisman A, Lobo C, Cho H, Campbell JK, Dufour YS, Stevens AM, Levchenko A. A microfluidic chemostat for experiments with bacterial and yeast cells. Nat Methods. 2005 Sep; 2(9):685-9. PMID: 16118639.
        View in: PubMed
      59. Simonnet C, Groisman A. Chaotic mixing in a steady flow in a microchannel. Phys Rev Lett. 2005 Apr 8; 94(13):134501. PMID: 15903994.
        View in: PubMed
      60. Burghelea T, Segre E, Bar-Joseph I, Groisman A, Steinberg V. Chaotic flow and efficient mixing in a microchannel with a polymer solution. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Jun; 69(6 Pt 2):066305. PMID: 15244724.
        View in: PubMed