Alessandra Franco

Title(s)Adjunct Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    How immunodominant Fc peptide epitopes expand natural regulatory T cells and downregulate inflammation
    NIH R01AI143586Jan 23, 2019 - Dec 31, 2021
    Role: Principal Investigator
    Impact of TNFa blockade on immune function in acute Kawasaki disease
    NIH R01HL103536Apr 15, 2010 - Feb 28, 2015
    Role: Principal Investigator
    GENERATION OF THOMSEN-FREIDENREICH-SPECIFIC T CELLS
    NIH R29CA078657Jul 1, 1998 - Aug 31, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. More on Pre-Covid-19, SARS-CoV-2-Negative MIS-C. N Engl J Med. 2024 Feb 22; 390(8):771. Franco A, Tremoulet A, Burns JC. PMID: 38381691.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. T Cell Responses in Pregnant Women Who Received mRNA-Based Vaccination to Prevent COVID-19 Revealed Unknown Exposure to the Natural Infection and Numerous SARS-CoV-2-Specific CD4- CD8- Double Negative T Cells and Regulatory T Cells. Int J Mol Sci. 2024 Feb 07; 25(4). Chambers CD, Song J, da Silva Antunes R, Sette A, Franco A. PMID: 38396707.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    3. SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19. Autoimmunity. 2023 12; 56(1):2259133. Franco A, Song J, Chambers C, Sette A, Grifoni A. PMID: 37724524.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    4. T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells. Int J Mol Sci. 2022 Jun 29; 23(13). Hsieh LE, Song J, Grifoni A, Shimizu C, Tremoulet AH, Dummer KB, Burns JC, Sette A, Franco A. PMID: 35806225; PMCID: PMC9266459.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Intravenous immunoglobulin induces IgG internalization by tolerogenic myeloid dendritic cells that secrete IL-10 and expand Fc-specific regulatory T cells. Clin Exp Immunol. 2022 06 23; 208(3):361-371. Hsieh LE, Song J, Tremoulet AH, Burns JC, Franco A. PMID: 35536993; PMCID: PMC9226148.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    6. Immune Regulatory Functions of IgG in the Ontogeny of Human Natural Regulatory T Cells. Crit Rev Immunol. 2022; 42(2):29-33. Franco A. PMID: 37017286.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Anakinra Treatment in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysms: A Phase I/IIa Trial. J Pediatr. 2022 04; 243:173-180.e8. Yang J, Jain S, Capparelli EV, Best BM, Son MB, Baker A, Newburger JW, Franco A, Printz BF, He F, Shimizu C, Hoshino S, Bainto E, Moreno E, Pancheri J, Burns JC, Tremoulet AH. PMID: 34953816.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    8. SARS-CoV-2-specific T cell responses and immune regulation in infected pregnant women. J Reprod Immunol. 2022 02; 149:103464. Hsieh LE, Grifoni A, Dave H, Wang J, Johnson D, Zellner J, Sidney J, Chambers C, Franco A. PMID: 34953325; PMCID: PMC8665650.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. Characterization of SARS-CoV-2 and common cold coronavirus-specific T-cell responses in MIS-C and Kawasaki disease children. Eur J Immunol. 2022 01; 52(1):123-137. Hsieh LE, Grifoni A, Sidney J, Shimizu C, Shike H, Ramchandar N, Moreno E, Tremoulet AH, Burns JC, Franco A. PMID: 34599760; PMCID: PMC8646471.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsCTClinical Trials
    10. Characterization of the T Cell Response to Lactobacillus casei Cell Wall Extract in Children With Kawasaki Disease and Its Potential Role in Vascular Inflammation. Front Pediatr. 2021; 9:633244. Hsieh LE, Tremoulet AH, Burns JC, Noval Rivas M, Arditi M, Franco A. PMID: 33681107; PMCID: PMC7933244.
      View in: PubMed   Mentions: 1  
    11. IgG Epitopes Processed and Presented by IgG+ B Cells Induce Suppression by Human Thymic-Derived Regulatory T Cells. J Immunol. 2021 03 15; 206(6):1194-1203. Hsieh LE, Sidney J, Burns JC, Boyle DL, Firestein GS, Altman Y, Sette A, Franco A. PMID: 33579724; PMCID: PMC7939040.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    12. Phase I/IIa Trial of Atorvastatin in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysm. J Pediatr. 2019 12; 215:107-117.e12. Tremoulet AH, Jain S, Jone PN, Best BM, Duxbury EH, Franco A, Printz B, Dominguez SR, Heizer H, Anderson MS, Glodé MP, He F, Padilla RL, Shimizu C, Bainto E, Pancheri J, Cohen HJ, Whitin JC, Burns JC. PMID: 31561960; PMCID: PMC6878161.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    13. HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease. Hum Immunol. 2019 Sep; 80(9):731-738. Shimizu C, Kim J, Eleftherohorinou H, Wright VJ, Hoang LT, Tremoulet AH, Franco A, Hibberd ML, Takahashi A, Kubo M, Ito K, Tanaka T, Onouchi Y, Coin LJM, Levin M, Burns JC, Shike H, International Kawasaki Disease Genetic Consortium. PMID: 31122742; PMCID: PMC10793643.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Pediatric tolerogenic DCs expressing CD4 and immunoglobulin-like transcript receptor (ILT)-4 secrete IL-10 in response to Fc and adenosine. Eur J Immunol. 2018 03; 48(3):482-491. Franco A, Kumar J, Lin G, Behnamfar N, Hsieh LE, Shimizu C, Tremoulet AH, Burns JC, Linden J. PMID: 29244203.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    15. The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1. Gut. 2017 09; 66(9):1584-1596. Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang JT, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E. PMID: 27325418; PMCID: PMC5173457.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    16. Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (the ANAKID trial). Contemp Clin Trials. 2016 05; 48:70-5. Tremoulet AH, Jain S, Kim S, Newburger J, Arditi M, Franco A, Best B, Burns JC. PMID: 27080929; PMCID: PMC5221485.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCTClinical Trials
    17. Introduction. Autoimmunity. 2015 May; 48(3):137-8. Franco A. PMID: 25831239.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Fine specificities of natural regulatory T cells after IVIG therapy in patients with Kawasaki disease. Autoimmunity. 2015 May; 48(3):181-8. Burns JC, Touma R, Song Y, Padilla RL, Tremoulet AH, Sidney J, Sette A, Franco A. PMID: 25822882; PMCID: PMC4784966.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    19. The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease. Expert Rev Clin Immunol. 2015; 11(7):819-25. Burns JC, Franco A. PMID: 26099344; PMCID: PMC4985263.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    20. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. PMID: 25282159; PMCID: PMC4843825.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    21. Specificity of regulatory T cells that modulate vascular inflammation. Autoimmunity. 2014 Mar; 47(2):95-104. Franco A, Touma R, Song Y, Shimizu C, Tremoulet AH, Kanegaye JT, Burns JC. PMID: 24490882.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCellsCTClinical Trials
    22. Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G. PLoS One. 2013; 8(12):e81448. Ogata S, Shimizu C, Franco A, Touma R, Kanegaye JT, Choudhury BP, Naidu NN, Kanda Y, Hoang LT, Hibberd ML, Tremoulet AH, Varki A, Burns JC. PMID: 24324693; PMCID: PMC3855660.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    23. The role of TGF-β and myofibroblasts in the arteritis of Kawasaki disease. Hum Pathol. 2013 Feb; 44(2):189-98. Shimizu C, Oharaseki T, Takahashi K, Kottek A, Franco A, Burns JC. PMID: 22955109; PMCID: PMC3518690.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    24. Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease. J Pediatr. 2012 Sep; 161(3):506-512.e1. Tremoulet AH, Pancoast P, Franco A, Bujold M, Shimizu C, Onouchi Y, Tamamoto A, Erdem G, Dodd D, Burns JC. PMID: 22484354; PMCID: PMC3613150.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    25. Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones. Cell Immunol. 2010; 266(1):1-6. Franco A, Almanza G, Burns JC, Wheeler M, Zanetti M. PMID: 20951371.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    26. Memory T-cells and characterization of peripheral T-cell clones in acute Kawasaki disease. Autoimmunity. 2010 Jun; 43(4):317-24. Franco A, Shimizu C, Tremoulet AH, Burns JC. PMID: 20166878; PMCID: PMC2871072.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    27. Glycoconjugates as vaccines for cancer immunotherapy: clinical trials and future directions. Anticancer Agents Med Chem. 2008 Jan; 8(1):86-91. Franco A. PMID: 18220508.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    28. Translating the concept of suppressor/regulatory T cells to clinical applications. Int Rev Immunol. 2006 Jan-Apr; 25(1-2):27-47. Franco A, Albani S. PMID: 16669133.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
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