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    Alan Saghatelian

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentCell and Developmental Biology
    Address9500 Gilman Drive #0932
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. Nature. 2017 Sep 20; 549(7673):548-552. PMID: 28959974.
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      2. Chu Q, Rathore A, Diedrich JK, Donaldson CJ, Yates JR, Saghatelian A. Identification of Microprotein-Protein Interactions via APEX Tagging. Biochemistry. 2017 Jul 05; 56(26):3299-3306. PMID: 28589727.
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      3. Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 Apr 05; 139(13):4943-4947. PMID: 28350171.
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      4. Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Sci Rep. 2017 Feb 27; 7:43515. PMID: 28240264.
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      5. Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. Cell Metab. 2017 Feb 07; 25(2):463-471. PMID: 28089566.
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      6. Chen P, Zuo H, Xiong H, Kolar MJ, Chu Q, Saghatelian A, Siegwart DJ, Wan Y. Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A. 2017 Jan 17; 114(3):580-585. PMID: 28049847.
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      7. Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab. 2017 Feb 07; 25(2):412-427. PMID: 28041958.
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      8. Matsumoto A, Pasut A, Matsumoto M, Yamashita R, Fung J, Monteleone E, Saghatelian A, Nakayama KI, Clohessy JG, Pandolfi PP. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Nature. 2017 01 12; 541(7636):228-232. PMID: 28024296.
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      9. Krzeszinski JY, Schwaid AG, Cheng WY, Jin Z, Gallegos ZR, Saghatelian A, Wan Y. Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis. Endocrinology. 2016 Dec 14; en20161570. PMID: 27967239.
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      10. D'Lima NG, Ma J, Winkler L, Chu Q, Loh KH, Corpuz EO, Budnik BA, Lykke-Andersen J, Saghatelian A, Slavoff SA. A human microprotein that interacts with the mRNA decapping complex. Nat Chem Biol. 2017 Feb; 13(2):174-180. PMID: 27918561.
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      11. Saghatelian A, Cravatt B. Glucagon and Thyroid Hormone: A Championship Team. Cell. 2016 Oct 20; 167(3):604-605. PMID: 27768884.
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      12. Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ, Saghatelian A, Kapeller R, Metallo CM, Shaw RJ. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 Oct; 22(10):1108-1119. PMID: 27643638.
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      13. Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. J Biol Chem. 2016 Oct 14; 291(42):22207-22217. PMID: 27573241.
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      14. Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 2016 Aug 23; 55(33):4636-41. PMID: 27509211.
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      15. Chu Q, Diedrich JK, Vaughan JM, Donaldson CJ, Nunn MF, Lee KF, Saghatelian A. HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective. J Am Chem Soc. 2016 Aug 3; 138(30):9473-8. PMID: 27379525.
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      16. Moraes-Vieira PM, Saghatelian A, Kahn BB. GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects. Diabetes. 2016 Jul; 65(7):1808-15. PMID: 27288004; PMCID: PMC4915575 [Available on 07/01/17].
      17. Parsons WH, Kolar MJ, Kamat SS, Iii AB, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016 May; 12(5):367-72. PMID: 27018888.
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      18. Ma J, Diedrich JK, Jungreis I, Donaldson C, Vaughan J, Kellis M, Yates JR, Saghatelian A. Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides. Anal Chem. 2016 Apr 05; 88(7):3967-75. PMID: 27010111; PMCID: PMC4939623 [Available on 04/05/17].
      19. Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nat Protoc. 2016 Apr; 11(4):747-63. PMID: 26985573; PMCID: PMC4797065 [Available on 10/01/16].
      20. Wei W, Schwaid AG, Wang X, Wang X, Chen S, Chu Q, Saghatelian A, Wan Y. Ligand Activation of ERRa by Cholesterol Mediates Statin and Bisphosphonate Effects. Cell Metab. 2016 Mar 08; 23(3):479-91. PMID: 26777690; PMCID: PMC4785078 [Available on 03/08/17].
      21. Saghatelian A, Nomura DK, Weerapana E. Editorial overview: Omics: The maturation of chemical biology. Curr Opin Chem Biol. 2016 Feb; 30:v-vi. PMID: 26739665.
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      22. Saghatelian A, Couso JP. Discovery and characterization of smORF-encoded bioactive polypeptides. Nat Chem Biol. 2015 Dec; 11(12):909-16. PMID: 26575237; PMCID: PMC4956473 [Available on 12/01/16].
      23. Denli AM, Narvaiza I, Kerman BE, Pena M, Benner C, Marchetto MC, Diedrich JK, Aslanian A, Ma J, Moresco JJ, Moore L, Hunter T, Saghatelian A, Gage FH. Primate-specific ORF0 contributes to retrotransposon-mediated diversity. Cell. 2015 Oct 22; 163(3):583-93. PMID: 26496605.
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      24. Zhang T, Barclay L, Walensky LD, Saghatelian A. Regulation of mitochondrial ceramide distribution by members of the BCL-2 family. J Lipid Res. 2015 Aug; 56(8):1501-10. PMID: 26059977; PMCID: PMC4513991.
      25. Zamboni N, Saghatelian A, Patti GJ. Defining the metabolome: size, flux, and regulation. Mol Cell. 2015 May 21; 58(4):699-706. PMID: 26000853; PMCID: PMC4831058.
      26. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC. An alternative pluripotent state confers interspecies chimaeric competency. Nature. 2015 May 21; 521(7552):316-21. PMID: 25945737.
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      27. Kim KJ, Kim YW, Kim YG, Park HM, Jin JM, Hwan Kim Y, Yang YH, Kyu Lee J, Chung J, Lee SG, Saghatelian A. Stable isotopic labeling-based quantitative targeted glycomics (i-QTaG). Biotechnol Prog. 2015 May-Jun; 31(3):840-8. PMID: 25832445.
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      28. Chu Q, Ma J, Saghatelian A. Identification and characterization of sORF-encoded polypeptides. Crit Rev Biochem Mol Biol. 2015 Mar-Apr; 50(2):134-41. PMID: 25857697; PMCID: PMC4761265.
      29. Zhang T, Walensky LD, Saghatelian A. A nonapoptotic role for BAX and BAK in eicosanoid metabolism. ACS Chem Biol. 2015 Jun 19; 10(6):1398-403. PMID: 25815636; PMCID: PMC4599777.
      30. Jin Z, Du Y, Schwaid AG, Asterholm IW, Scherer PE, Saghatelian A, Wan Y. Maternal adiponectin controls milk composition to prevent neonatal inflammation. Endocrinology. 2015 Apr; 156(4):1504-13. PMID: 25590242; PMCID: PMC4399311.
      31. Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Data-driven synthesis of proteolysis-resistant peptide hormones. J Am Chem Soc. 2014 Dec 24; 136(51):17710-3. PMID: 25496053.
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      32. Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 09; 159(2):318-32. PMID: 25303528; PMCID: PMC4260972.
      33. Johnson LM, Barrick S, Hager MV, McFedries A, Homan EA, Rabaglia ME, Keller MP, Attie AD, Saghatelian A, Bisello A, Gellman SH. A potent a/ß-peptide analogue of GLP-1 with prolonged action in vivo. J Am Chem Soc. 2014 Sep 17; 136(37):12848-51. PMID: 25191938; PMCID: PMC4183665.
      34. Nazarian A, Lawlor K, Yi SS, Philip J, Ghosh M, Yaneva M, Villanueva J, Saghatelian A, Assel M, Vickers AJ, Eastham JA, Scher HI, Carver BS, Lilja H, Tempst P. Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer. Mol Cell Proteomics. 2014 Nov; 13(11):3082-96. PMID: 25056937; PMCID: PMC4223493.
      35. Oliver PM, Crooks JA, Leidl M, Yoon EJ, Saghatelian A, Weibel DB. Localization of anionic phospholipids in Escherichia coli cells. J Bacteriol. 2014 Oct; 196(19):3386-98. PMID: 25002539; PMCID: PMC4187673.
      36. Maianti JP, McFedries A, Foda ZH, Kleiner RE, Du XQ, Leissring MA, Tang WJ, Charron MJ, Seeliger MA, Saghatelian A, Liu DR. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. 2014 Jul 03; 511(7507):94-8. PMID: 24847884; PMCID: PMC4142213.
      37. Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. The metabolite a-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014 Jun 19; 510(7505):397-401. PMID: 24828042.
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      38. Slavoff SA, Heo J, Budnik BA, Hanakahi LA, Saghatelian A. A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. J Biol Chem. 2014 Apr 18; 289(16):10950-7. PMID: 24610814; PMCID: PMC4036235.
      39. Lone AM, Leidl M, McFedries AK, Horner JW, Creemers J, Saghatelian A. Deletion of PREPl causes growth impairment and hypotonia in mice. PLoS One. 2014; 9(2):e89160. PMID: 24586561; PMCID: PMC3938459.
      40. Ma J, Ward CC, Jungreis I, Slavoff SA, Schwaid AG, Neveu J, Budnik BA, Kellis M, Saghatelian A. Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue. J Proteome Res. 2014 Mar 07; 13(3):1757-65. PMID: 24490786; PMCID: PMC3993966.
      41. Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science. 2014 Feb 14; 343(6172):1248636. PMID: 24407481; PMCID: PMC4107353.
      42. Schwaid AG, Shannon DA, Ma J, Slavoff SA, Levin JZ, Weerapana E, Saghatelian A. Chemoproteomic discovery of cysteine-containing human short open reading frames. J Am Chem Soc. 2013 Nov 13; 135(45):16750-3. PMID: 24152191.
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      43. Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 2013 Oct 24; 502(7472):550-4. PMID: 24153306; PMCID: PMC4141623.
      44. López-Sagaseta J, Dulberger CL, McFedries A, Cushman M, Saghatelian A, Adams EJ. MAIT recognition of a stimulatory bacterial antigen bound to MR1. J Immunol. 2013 Nov 15; 191(10):5268-77. PMID: 24108697; PMCID: PMC3819123.
      45. Kim YG, Lone AM, Saghatelian A. Analysis of the proteolysis of bioactive peptides using a peptidomics approach. Nat Protoc. 2013 Sep; 8(9):1730-42. PMID: 23949379; PMCID: PMC4170687.
      46. Mitchell AJ, Lone AM, Tinoco AD, Saghatelian A. Proteolysis controls endogenous substance P levels. PLoS One. 2013; 8(7):e68638. PMID: 23894327; PMCID: PMC3716696.
      47. Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1788-94. PMID: 23723371; PMCID: PMC3794714.
      48. McFedries A, Schwaid A, Saghatelian A. Methods for the elucidation of protein-small molecule interactions. Chem Biol. 2013 May 23; 20(5):667-73. PMID: 23706633.
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      49. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24; 5(7):940-63. PMID: 23685806; PMCID: PMC3759823.
      50. López-Sagaseta J, Dulberger CL, Crooks JE, Parks CD, Luoma AM, McFedries A, Van Rhijn I, Saghatelian A, Adams EJ. The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):E1771-8. PMID: 23613577; PMCID: PMC3651419.
      51. Zhang T, Saghatelian A. Emerging roles of lipids in BCL-2 family-regulated apoptosis. Biochim Biophys Acta. 2013 Oct; 1831(10):1542-54. PMID: 23524027.
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      52. Lone AM, Kim YG, Saghatelian A. Peptidomics methods for the identification of peptidase-substrate interactions. Curr Opin Chem Biol. 2013 Feb; 17(1):83-9. PMID: 23332665; PMCID: PMC3594040.
      53. Slavoff SA, Mitchell AJ, Schwaid AG, Cabili MN, Ma J, Levin JZ, Karger AD, Budnik BA, Rinn JL, Saghatelian A. Peptidomic discovery of short open reading frame-encoded peptides in human cells. Nat Chem Biol. 2013 Jan; 9(1):59-64. PMID: 23160002; PMCID: PMC3625679.
      54. Slavoff SA, Saghatelian A. Discovering ligand-receptor interactions. Nat Biotechnol. 2012 Oct; 30(10):959-61. PMID: 23051814.
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      55. Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A, Wan Y. Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. Genes Dev. 2012 Jun 15; 26(12):1306-11. PMID: 22713870; PMCID: PMC3387658.
      56. Kim YG, Lone AM, Nolte WM, Saghatelian A. Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8523-7. PMID: 22586115; PMCID: PMC3365226.
      57. Tinoco AD, Thomas HR, Incarvito CD, Saghatelian A, Valentine AM. Cytotoxicity of a Ti(IV) compound is independent of serum proteins. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5016-21. PMID: 22411801; PMCID: PMC3323991.
      58. Guzman-Rojas L, Rangel R, Salameh A, Edwards JK, Dondossola E, Kim YG, Saghatelian A, Giordano RJ, Kolonin MG, Staquicini FI, Koivunen E, Sidman RL, Arap W, Pasqualini R. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1637-42. PMID: 22307623; PMCID: PMC3277167.
      59. Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A, Wan Y. Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. Nat Commun. 2012; 3:1008. PMID: 22910354; PMCID: PMC3520613.
      60. Kim YG, Saghatelian A. Functional analysis of protein targets by metabolomic approaches. Top Curr Chem. 2012; 324:137-62. PMID: 22083210.
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      61. Vinayavekhin N, Saghatelian A. Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. J Am Chem Soc. 2011 Nov 02; 133(43):17168-71. PMID: 21973308; PMCID: PMC4569094.
      62. Tinoco AD, Saghatelian A. Investigating endogenous peptides and peptidases using peptidomics. Biochemistry. 2011 Sep 06; 50(35):7447-61. PMID: 21786763; PMCID: PMC3418817.
      63. Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF, Saghatelian A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. J Am Chem Soc. 2011 Aug 03; 133(30):11665-74. PMID: 21692504; PMCID: PMC3145007.
      64. Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky J. VLDL hydrolysis by hepatic lipase regulates PPARd transcriptional responses. PLoS One. 2011; 6(7):e21209. PMID: 21750705; PMCID: PMC3130023.
      65. Homan EA, Kim YG, Cardia JP, Saghatelian A. Monoalkylglycerol ether lipids promote adipogenesis. J Am Chem Soc. 2011 Apr 13; 133(14):5178-81. PMID: 21428285; PMCID: PMC4761264.
      66. Tinoco AD, Kim YG, Tagore DM, Wiwczar J, Lane WS, Danial NN, Saghatelian A. A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. Biochemistry. 2011 Mar 29; 50(12):2213-22. PMID: 21299233; PMCID: PMC3076939.
      67. Kim YG, Lou AC, Saghatelian A. A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands. Mol Biosyst. 2011 Apr; 7(4):1046-9. PMID: 21283866.
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      68. Scharf L, Li NS, Hawk AJ, Garzón D, Zhang T, Fox LM, Kazen AR, Shah S, Haddadian EJ, Gumperz JE, Saghatelian A, Faraldo-Gómez JD, Meredith SC, Piccirilli JA, Adams EJ. The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity. 2010 Dec 14; 33(6):853-62. PMID: 21167756; PMCID: PMC3010391.
      69. Lone AM, Nolte WM, Tinoco AD, Saghatelian A. Peptidomics of the prolyl peptidases. AAPS J. 2010 Dec; 12(4):483-91. PMID: 20552307; PMCID: PMC2976987.
      70. Vinayavekhin N, Saghatelian A. Untargeted metabolomics. Curr Protoc Mol Biol. 2010 Apr; Chapter 30:Unit 30.1.1-24. PMID: 20373502.
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      71. Tinoco AD, Tagore DM, Saghatelian A. Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform. J Am Chem Soc. 2010 Mar 24; 132(11):3819-30. PMID: 20178363; PMCID: PMC2842575.
      72. Vinayavekhin N, Homan EA, Saghatelian A. Exploring disease through metabolomics. ACS Chem Biol. 2010 Jan 15; 5(1):91-103. PMID: 20020774.
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      73. Nolte WM, Tagore DM, Lane WS, Saghatelian A. Peptidomics of prolyl endopeptidase in the central nervous system. Biochemistry. 2009 Dec 22; 48(50):11971-81. PMID: 19911840; PMCID: PMC2813186.
      74. MacBeath G, Saghatelian A. The promise and challenge of '-omic' approaches. Curr Opin Chem Biol. 2009 Dec; 13(5-6):501-2. PMID: 19853495.
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      75. Vinayavekhin N, Saghatelian A. Regulation of alkyl-dihydrothiazole-carboxylates (ATCs) by iron and the pyochelin gene cluster in Pseudomonas aeruginosa. ACS Chem Biol. 2009 Aug 21; 4(8):617-23. PMID: 19621937.
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      76. Rodgers MA, Saghatelian A, Yang PL. Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling. J Am Chem Soc. 2009 Apr 15; 131(14):5030-1. PMID: 19301856; PMCID: PMC4166558.
      77. Tagore DM, Nolte WM, Neveu JM, Rangel R, Guzman-Rojas L, Pasqualini R, Arap W, Lane WS, Saghatelian A. Peptidase substrates via global peptide profiling. Nat Chem Biol. 2009 Jan; 5(1):23-5. PMID: 19011639; PMCID: PMC2730040.
      78. Tagore R, Thomas HR, Homan EA, Munawar A, Saghatelian A. A global metabolite profiling approach to identify protein-metabolite interactions. J Am Chem Soc. 2008 Oct 29; 130(43):14111-3. PMID: 18831549.
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      79. Voelcker NH, Guckian KM, Saghatelian A, Ghadiri MR. Sequence-addressable DNA logic. Small. 2008 Apr; 4(4):427-31. PMID: 18350554.
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      80. Chamero P, Marton TF, Logan DW, Flanagan K, Cruz JR, Saghatelian A, Cravatt BF, Stowers L. Identification of protein pheromones that promote aggressive behaviour. Nature. 2007 Dec 06; 450(7171):899-902. PMID: 18064011.
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      81. Wan Y, Saghatelian A, Chong LW, Zhang CL, Cravatt BF, Evans RM. Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. Genes Dev. 2007 Aug 01; 21(15):1895-908. PMID: 17652179; PMCID: PMC1935028.
      82. Everley PA, Gartner CA, Haas W, Saghatelian A, Elias JE, Cravatt BF, Zetter BR, Gygi SP. Assessing enzyme activities using stable isotope labeling and mass spectrometry. Mol Cell Proteomics. 2007 Oct; 6(10):1771-7. PMID: 17627935.
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      83. Ostash B, Saghatelian A, Walker S. A streamlined metabolic pathway for the biosynthesis of moenomycin A. Chem Biol. 2007 Mar; 14(3):257-67. PMID: 17379141; PMCID: PMC1936435.
      84. Chiang KP, Niessen S, Saghatelian A, Cravatt BF. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol. 2006 Oct; 13(10):1041-50. PMID: 17052608.
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      85. Saghatelian A, McKinney MK, Bandell M, Patapoutian A, Cravatt BF. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry. 2006 Aug 01; 45(30):9007-15. PMID: 16866345.
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      86. Leung D, Saghatelian A, Simon GM, Cravatt BF. Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry. 2006 Apr 18; 45(15):4720-6. PMID: 16605240; PMCID: PMC1538545.
      87. Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nat Biotechnol. 2005 Oct; 23(10):1303-7. PMID: 16200062.
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      88. Saghatelian A, Cravatt BF. Discovery metabolite profiling--forging functional connections between the proteome and metabolome. Life Sci. 2005 Aug 19; 77(14):1759-66. PMID: 15964030.
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      89. Saghatelian A, Cravatt BF. Assignment of protein function in the postgenomic era. Nat Chem Biol. 2005 Aug; 1(3):130-42. PMID: 16408016.
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      90. Go EP, Apon JV, Luo G, Saghatelian A, Daniels RH, Sahi V, Dubrow R, Cravatt BF, Vertes A, Siuzdak G. Desorption/ionization on silicon nanowires. Anal Chem. 2005 Mar 15; 77(6):1641-6. PMID: 15762567.
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      91. Saghatelian A, Cravatt BF. Global strategies to integrate the proteome and metabolome. Curr Opin Chem Biol. 2005 Feb; 9(1):62-8. PMID: 15701455.
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      92. Saghatelian A, Trauger SA, Want EJ, Hawkins EG, Siuzdak G, Cravatt BF. Assignment of endogenous substrates to enzymes by global metabolite profiling. Biochemistry. 2004 Nov 16; 43(45):14332-9. PMID: 15533037.
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      93. Cravatt BF, Saghatelian A, Hawkins EG, Clement AB, Bracey MH, Lichtman AH. Functional disassociation of the central and peripheral fatty acid amide signaling systems. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10821-6. PMID: 15247426; PMCID: PMC490018.
      94. Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL, Cravatt BF. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. J Pharmacol Exp Ther. 2004 Nov; 311(2):441-8. PMID: 15229230.
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      95. Saghatelian A, Jessani N, Joseph A, Humphrey M, Cravatt BF. Activity-based probes for the proteomic profiling of metalloproteases. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10000-5. PMID: 15220480; PMCID: PMC454150.
      96. Sánchez-Quesada J, Saghatelian A, Cheley S, Bayley H, Ghadiri MR. Single DNA rotaxanes of a transmembrane pore protein. Angew Chem Int Ed Engl. 2004 Jun 07; 43(23):3063-7. PMID: 15188482; PMCID: PMC1866269.
      97. Saghatelian A, Guckian KM, Thayer DA, Ghadiri MR. DNA detection and signal amplification via an engineered allosteric enzyme. J Am Chem Soc. 2003 Jan 15; 125(2):344-5. PMID: 12517141; PMCID: PMC2453066.
      98. Saghatelian A, Völcker NH, Guckian KM, Lin VS, Ghadiri MR. DNA-based photonic logic gates: AND, NAND, and INHIBIT. J Am Chem Soc. 2003 Jan 15; 125(2):346-7. PMID: 12517142.
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      99. Merlic CA, Aldrich CC, Albaneze-Walker J, Saghatelian A, Mammen J. Total synthesis of the calphostins: application of fischer carbene complexes and thermodynamic control of atropisomers. J Org Chem. 2001 Feb 23; 66(4):1297-309. PMID: 11312960.
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      100. Saghatelian A, Yokobayashi Y, Soltani K, Ghadiri MR. A chiroselective peptide replicator. Nature. 2001 Feb 15; 409(6822):797-801. PMID: 11236988.
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      101. Merlic CA, Aldrich CC, Albaneze-Walker J, Saghatelian A. Carbene Complexes in the Synthesis of Complex Natural Products: Total Synthesis of the Calphostins. J Am Chem Soc. 2000 Apr 05; 122(13):3224-3225. PMID: 23335811.
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