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    Adah Almutairi

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0600
    CA La Jolla 92093
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      Professor Adah Almutairi has been a faculty member at the University of California, San Diego since 2008. She is the director of UCSD's Center of Excellence in Nanomedicine, a rapidly expanding interdisciplinary research collaborative team developing tools for the future of biology and medicine. Her primary appointment is in the Skaggs School of Pharmacy and Pharmaceutical Sciences, and she is a member of the departments of NanoEngineering, and Radiology. She came to UC San Diego from UC Berkeley, where she worked with Professor Jean Fréchet to develop several nanoprobes for in vivo imaging. Prior to that, she completed her PhD in Materials Chemistry at UC Riverside on electron delocalization and molecular structure, in which she developed a novel polymer for electromechanical actuation.

      Collapse Research 
      Collapse Research Activities and Funding
      Biomaterial enhancement of stem cell transplant efficacy for macular degeneration
      NIH/NEI R01EY024134Feb 1, 2014 - Jan 31, 2017
      Role: Principal Investigator
      Chemically amplified response strategies for medical sciences;concepts borrowed
      NIH DP2OD006499Sep 30, 2009 - Jun 30, 2014
      Role: Principal Investigator

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sheng W, He S, Seare WJ, Almutairi A. Review of the progress toward achieving heat confinement-the holy grail of photothermal therapy. J Biomed Opt. 2017 Aug 01; 22(8):80901. PMID: 28776627.
        View in: PubMed
      2. He S, Johnson NJJ, Nguyen Huu VA, Cory E, Huang Y, Sah RL, Jokerst JV, Almutairi A. Simultaneous Enhancement of Photoluminescence, MRI Relaxivity, and CT Contrast by Tuning the Interfacial Layer of Lanthanide Heteroepitaxial Nanoparticles. Nano Lett. 2017 Aug 09; 17(8):4873-4880. PMID: 28657755.
        View in: PubMed
      3. Viger ML, Collet G, Lux J, Nguyen Huu VA, Guma M, Foucault-Collet A, Olejniczak J, Joshi-Barr S, Firestein GS, Almutairi A. Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast. Biomaterials. 2017 Jul; 133:119-131. PMID: 28433935.
        View in: PubMed
      4. Johnson NJ, He S, Diao S, Chan EM, Dai H, Almutairi A. Direct Evidence for Coupled Surface and Concentration Quenching Dynamics in Lanthanide-Doped Nanocrystals. J Am Chem Soc. 2017 Mar 01; 139(8):3275-3282. PMID: 28169535.
        View in: PubMed
      5. Olejniczak J, Collet G, Nguyen Huu VA, Chan M, Lee S, Almutairi A. Biorthogonal click chemistry on poly(lactic-co-glycolic acid)-polymeric particles. Biomater Sci. 2017 Jan 31; 5(2):211-215. PMID: 27981322.
        View in: PubMed
      6. Johnson NJ, He S, Nguyen Huu VA, Almutairi A. Compact Micellization: A Strategy for Ultrahigh T1 Magnetic Resonance Contrast with Gadolinium-Based Nanocrystals. ACS Nano. 2016 Sep 27; 10(9):8299-307. PMID: 27588579.
        View in: PubMed
      7. Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A. Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3185-90. PMID: 26944080; PMCID: PMC4812712.
      8. Carling CJ, Olejniczak J, Foucault-Collet A, Collet G, Viger ML, Huu VA, Duggan BM, Almutairi A. Efficient Red Light Photo-Uncaging of Active Molecules in Water Upon Assembly into Nanoparticles. Chem Sci. 2016 Mar; 7(3):2392-2398. PMID: 27014436.
        View in: PubMed
      9. Olejniczak J, Nguyen Huu VA, Lux J, Grossman M, He S, Almutairi A. Light-triggered chemical amplification to accelerate degradation and release from polymeric particles. Chem Commun (Camb). 2015 Dec 11; 51(95):16980-3. PMID: 26445896; PMCID: PMC4819761.
      10. Chan M, Almutairi A. Nanogels as imaging agents for modalities spanning the electromagnetic spectrum. Mater Horiz. 2016 Jan 21; 3(1):21-40. PMID: 27398218.
        View in: PubMed
      11. de Gracia Lux C, Lux J, Collet G, He S, Chan M, Olejniczak J, Foucault-Collet A, Almutairi A. Short Soluble Coumarin Crosslinkers for Light-Controlled Release of Cells and Proteins from Hydrogels. Biomacromolecules. 2015 Oct 12; 16(10):3286-96. PMID: 26349005.
        View in: PubMed
      12. Olejniczak J, Carling CJ, Almutairi A. Photocontrolled release using one-photon absorption of visible or NIR light. J Control Release. 2015 Dec 10; 219:18-30. PMID: 26394063.
        View in: PubMed
      13. Chan M, Lux J, Nishimura T, Akiyoshi K, Almutairi A. Long-Lasting and Efficient Tumor Imaging Using a High Relaxivity Polysaccharide Nanogel Magnetic Resonance Imaging Contrast Agent. Biomacromolecules. 2015 Sep 14; 16(9):2964-71. PMID: 26278775.
        View in: PubMed
      14. Suarez SL, Rane AA, Muñoz A, Wright AT, Zhang SX, Braden RL, Almutairi A, McCulloch AD, Christman KL. Intramyocardial injection of hydrogel with high interstitial spread does not impact action potential propagation. Acta Biomater. 2015 Oct; 26:13-22. PMID: 26265060; PMCID: PMC4772723 [Available on 10/15/16].
      15. Wen JH, Choi O, Taylor-Weiner H, Fuhrmann A, Karpiak JV, Almutairi A, Engler AJ. Haptotaxis is cell type specific and limited by substrate adhesiveness. Cell Mol Bioeng. 2015 Dec 01; 8(4):530-542. PMID: 26640598.
        View in: PubMed
      16. Sheng W, Alhasan AH, DiBernardo G, Almutairi KM, Rubin JP, DiBernardo BE, Almutairi A. Gold Nanoparticle-assisted Selective Photothermolysis of Adipose Tissue (NanoLipo). Plast Reconstr Surg Glob Open. 2014 Dec; 2(12):e283. PMID: 25587517; PMCID: PMC4292265.
      17. Huu VA, Luo J, Zhu J, Zhu J, Patel S, Boone A, Mahmoud E, McFearin C, Olejniczak J, de Gracia Lux C, Lux J, Fomina N, Huynh M, Zhang K, Almutairi A. Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye. J Control Release. 2015 Feb 28; 200:71-7. PMID: 25571784; PMCID: PMC4384820.
      18. Lux J, White AG, Chan M, Anderson CJ, Almutairi A. Nanogels from metal-chelating crosslinkers as versatile platforms applied to copper-64 PET imaging of tumors and metastases. Theranostics. 2015; 5(3):277-88. PMID: 25553115; PMCID: PMC4279191.
      19. Carling CJ, Viger ML, Huu VA, Garcia AV, Almutairi A. In Vivo Visible Light-Triggered Drug Release From an Implanted Depot. Chem Sci. 2015 Jan 01; 6(1):335-341. PMID: 25598962.
        View in: PubMed
      20. Andrew MacKay J, Almutairi A, Hennink W, Hoffman AS. NanoDDS 2013: The 11th International Nano Drug Delivery Symposium. J Control Release. 2014 Oct 10; 191:1-3. PMID: 25091643.
        View in: PubMed
      21. Lantigua C, He S, Bouzan MA, Hayenga W, Johnson NJ, Almutairi A, Khajavikhan M. Engineering upconversion emission spectra using plasmonic nanocavities. Opt Lett. 2014 Jul 01; 39(13):3710-3. PMID: 24978717.
        View in: PubMed
      22. Memish ZA, Al-Tawfiq JA, Makhdoom HQ, Assiri A, Alhakeem RF, Albarrak A, Alsubaie S, Al-Rabeeah AA, Hajomar WH, Hussain R, Kheyami AM, Almutairi A, Azhar EI, Drosten C, Watson SJ, Kellam P, Cotten M, Zumla A. Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome. J Infect Dis. 2014 Nov 15; 210(10):1590-4. PMID: 24837403.
        View in: PubMed
      23. Joshi-Barr S, de Gracia Lux C, Mahmoud E, Almutairi A. Exploiting oxidative microenvironments in the body as triggers for drug delivery systems. Antioxid Redox Signal. 2014 Aug 10; 21(5):730-54. PMID: 24328819; PMCID: PMC4098119.
      24. Viger ML, Sheng W, Doré K, Alhasan AH, Carling CJ, Lux J, de Gracia Lux C, Grossman M, Malinow R, Almutairi A. Near-infrared-induced heating of confined water in polymeric particles for efficient payload release. ACS Nano. 2014 May 27; 8(5):4815-26. PMID: 24717072; PMCID: PMC4046803.
      25. Almutairi A, McCarthy A, Gardner GE. Understanding cultural competence in a multicultural nursing workforce: registered nurses' experience in Saudi Arabia. J Transcult Nurs. 2015 Jan; 26(1):16-23. PMID: 24626280.
        View in: PubMed
      26. Lux J, Chan M, Elst LV, Schopf E, Mahmoud E, Laurent S, Almutairi A. Metal Chelating Crosslinkers Form Nanogels with High Chelation Stability. J Mater Chem B Mater Biol Med. 2013 Dec 14; 1(46):6359-6364. PMID: 24505553.
        View in: PubMed
      27. Almutairi A, Gardner GE, McCarthy A. Practical guidance for the use of a pattern-matching technique in case-study research: a case presentation. Nurs Health Sci. 2014 Jun; 16(2):239-44. PMID: 24251820.
        View in: PubMed
      28. Suarez S, Grover GN, Braden RL, Christman KL, Almutairi A. Tunable protein release from acetalated dextran microparticles: a platform for delivery of protein therapeutics to the heart post-MI. Biomacromolecules. 2013 Nov 11; 14(11):3927-35. PMID: 24053580; PMCID: PMC3910395.
      29. Olejniczak J, Sankaranarayanan J, Viger ML, Almutairi A. Highest Efficiency Two-Photon Degradable Copolymer for Remote Controlled Release. ACS Macro Lett. 2013 Aug 20; 2(8):683-687. PMID: 24044102.
        View in: PubMed
      30. Almutairi A, Rondney P. Critical cultural competence for culturally diverse workforces: toward equitable and peaceful health care. ANS Adv Nurs Sci. 2013 Jul-Sep; 36(3):200-12. PMID: 23907302.
        View in: PubMed
      31. Viger ML, Sheng W, McFearin CL, Berezin MY, Almutairi A. Application of time-resolved fluorescence for direct and continuous probing of release from polymeric delivery vehicles. J Control Release. 2013 Nov 10; 171(3):308-14. PMID: 23792808; PMCID: PMC3795917.
      32. Viger ML, Grossman M, Fomina N, Almutairi A. Low power upconverted near-IR light for efficient polymeric nanoparticle degradation and cargo release. Adv Mater. 2013 Jul 19; 25(27):3733-8. PMID: 23722298; PMCID: PMC3980738.
      33. de Gracia Lux C, Almutairi A. Intramolecular Cyclization for Stimuli-Controlled Depolymerization of Polycaprolactone Particles Leading to Disassembly and Payload Release. ACS Macro Lett. 2013 May 21; 2(5):432-435. PMID: 23814697.
        View in: PubMed
      34. Viger ML, Sankaranarayanan J, de Gracia Lux C, Chan M, Almutairi A. Collective activation of MRI agents via encapsulation and disease-triggered release. J Am Chem Soc. 2013 May 29; 135(21):7847-50. PMID: 23672342; PMCID: PMC3680118.
      35. Joshi-Barr S, Karpiak JV, Ner Y, Wen JH, Engler AJ, Almutairi A. Density gradient multilayered polymerization (DGMP): a novel technique for creating multi-compartment, customizable scaffolds for tissue engineering. J Vis Exp. 2013 Feb 12; (72). PMID: 23426045; PMCID: PMC3601043.
      36. Almutairi A, Gardner G, McCarthy A. Perceptions of clinical safety climate of the multicultural nursing workforce in Saudi Arabia: a cross-sectional survey. Collegian. 2013; 20(3):187-94. PMID: 24151697.
        View in: PubMed
      37. Ruff LE, Mahmoud EA, Sankaranarayanan J, Morachis JM, Katayama CD, Corr M, Hedrick SM, Almutairi A. Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies. Integr Biol (Camb). 2013 Jan; 5(1):195-203. PMID: 23060228; PMCID: PMC3535018.
      38. de Gracia Lux C, Joshi-Barr S, Nguyen T, Mahmoud E, Schopf E, Fomina N, Almutairi A. Biocompatible polymeric nanoparticles degrade and release cargo in response to biologically relevant levels of hydrogen peroxide. J Am Chem Soc. 2012 Sep 26; 134(38):15758-64. PMID: 22946840; PMCID: PMC3478073.
      39. Chan M, Schopf E, Sankaranarayanan J, Almutairi A. Iron oxide nanoparticle-based magnetic resonance method to monitor release kinetics from polymeric particles with high resolution. Anal Chem. 2012 Sep 18; 84(18):7779-84. PMID: 22891894; PMCID: PMC3482982.
      40. Al-Hussaini A, Almutairi A, Mursi A, Alghofely M, Asery A. Isolated cortisol deficiency: a rare cause of neonatal cholestasis. Saudi J Gastroenterol. 2012 Sep-Oct; 18(5):339-41. PMID: 23006463; PMCID: PMC3500024.
      41. de Gracia Lux C, McFearin CL, Joshi-Barr S, Sankaranarayanan J, Fomina N, Almutairi A. A Single UV or Near IR Triggering Event Leads to Polymer Degradation into Small Molecules. ACS Macro Lett. 2012 Jul 17; 1(7):922-926. PMID: 23066523.
        View in: PubMed
      42. Morachis JM, Mahmoud EA, Sankaranarayanan J, Almutairi A. Triggered rapid degradation of nanoparticles for gene delivery. J Drug Deliv. 2012; 2012:291219. PMID: 22778965; PMCID: PMC3388356.
      43. Schopf E, Sankaranarayanan J, Chan M, Mattrey R, Almutairi A. An extracellular MRI polymeric contrast agent that degrades at physiological pH. Mol Pharm. 2012 Jul 02; 9(7):1911-8. PMID: 22657107; PMCID: PMC3443308.
      44. Morachis JM, Mahmoud EA, Almutairi A. Physical and chemical strategies for therapeutic delivery by using polymeric nanoparticles. Pharmacol Rev. 2012 Jul; 64(3):505-19. PMID: 22544864; PMCID: PMC3400833.
      45. Fomina N, McFearin CL, Almutairi A. Increasing materials' response to two-photon NIR light via self-immolative dendritic scaffolds. Chem Commun (Camb). 2012 Sep 21; 48(73):9138-40. PMID: 22475792; PMCID: PMC3421069.
      46. Fomina N, Sankaranarayanan J, Almutairi A. Photochemical mechanisms of light-triggered release from nanocarriers. Adv Drug Deliv Rev. 2012 Aug; 64(11):1005-20. PMID: 22386560; PMCID: PMC3395781.
      47. Karpiak JV, Ner Y, Almutairi A. Density gradient multilayer polymerization for creating complex tissue. Adv Mater. 2012 Mar 15; 24(11):1466-70. PMID: 22318771; PMCID: PMC3309044.
      48. Mahmoud EA, Sankaranarayanan J, Morachis JM, Kim G, Almutairi A. Inflammation responsive logic gate nanoparticles for the delivery of proteins. Bioconjug Chem. 2011 Jul 20; 22(7):1416-21. PMID: 21688843; PMCID: PMC3206642.
      49. McFearin CL, Sankaranarayanan J, Almutairi A. Application of fiber-optic attenuated total reflection-FT-IR methods for in situ characterization of protein delivery systems in real time. Anal Chem. 2011 May 15; 83(10):3943-9. PMID: 21476582; PMCID: PMC3094485.
      50. Roberts AG, Sjögren SE, Fomina N, Vu KT, Almutairi A, Halpert JR. NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation. Biochemistry. 2011 Mar 29; 50(12):2123-34. PMID: 21375273; PMCID: PMC3163098.
      51. Al Kadri HM, Al-Moamary MS, Elzubair M, Magzoub ME, AlMutairi A, Roberts C, van der Vleuten C. Exploring factors affecting undergraduate medical students' study strategies in the clinical years: a qualitative study. Adv Health Sci Educ Theory Pract. 2011 Dec; 16(5):553-67. PMID: 21207243; PMCID: PMC3226698.
      52. Fomina N, McFearin CL, Sermsakdi M, Morachis JM, Almutairi A. Low power, biologically benign NIR light triggers polymer disassembly. Macromolecules. 2011; 44(21):8590-8597. PMID: 22096258.
        View in: PubMed
      53. Sankaranarayanan J, Mahmoud EA, Kim G, Morachis JM, Almutairi A. Multiresponse strategies to modulate burst degradation and release from nanoparticles. ACS Nano. 2010 Oct 26; 4(10):5930-6. PMID: 20828178; PMCID: PMC2964039.
      54. Fomina N, McFearin C, Sermsakdi M, Edigin O, Almutairi A. UV and near-IR triggered release from polymeric nanoparticles. J Am Chem Soc. 2010 Jul 21; 132(28):9540-2. PMID: 20568765; PMCID: PMC2945686.
      55. Alwelaie YA, Alsuhaibani EA, Al-Harthy AM, Radwan RH, Al-Mohammady RG, Almutairi A. Breastfeeding knowledge and attitude among Saudi women in Central Saudi Arabia. Saudi Med J. 2010 Feb; 31(2):193-8. PMID: 20174738.
        View in: PubMed
      56. Alharbi M, Almutairi A, Alotaibi D, Alotaibi A, Shaikh S, Bahammam AS. The prevalence of asthma in patients with obstructive sleep apnoea. Prim Care Respir J. 2009 Dec; 18(4):328-30. PMID: 19407917.
        View in: PubMed
      57. Almutairi A, Hussain YA. Triangle of safety technique: a new approach to laparoscopic cholecystectomy. HPB Surg. 2009; 2009:476159. PMID: 19547662; PMCID: PMC2699444.
      58. Almutairi A, Sun Z, Ng C, Al-Safran ZA, Al-Mulla AA, Al-Jamaan AI. Optimal scanning protocols of 64-slice CT angiography in coronary artery stents: an in vitro phantom study. Eur J Radiol. 2010 Apr; 74(1):156-60. PMID: 19231124.
        View in: PubMed
      59. Almutairi A, Rossin R, Shokeen M, Hagooly A, Ananth A, Capoccia B, Guillaudeu S, Abendschein D, Anderson CJ, Welch MJ, Fréchet JM. Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis. Proc Natl Acad Sci U S A. 2009 Jan 20; 106(3):685-90. PMID: 19129498; PMCID: PMC2630081.
      60. Berezin MY, Lee H, Akers W, Guo K, Goiffon RJ, Almutairi A, Fréchet JM, Achilefu S. Engineering NIR dyes for fluorescent lifetime contrast. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:114-7. PMID: 19964923.
        View in: PubMed
      61. Sun Z, Almutairi A. Diagnostic accuracy of 64 multislice CT angiography in the assessment of coronary in-stent restenosis: a meta-analysis. Eur J Radiol. 2010 Feb; 73(2):266-73. PMID: 19056191.
        View in: PubMed
      62. Almutairi A, Akers WJ, Berezin MY, Achilefu S, Fréchet JM. Monitoring the biodegradation of dendritic near-infrared nanoprobes by in vivo fluorescence imaging. Mol Pharm. 2008 Nov-Dec; 5(6):1103-10. PMID: 19434857; PMCID: PMC2772156.
      63. Cohen JL, Almutairi A, Cohen JA, Bernstein M, Brody SL, Schuster DP, Fréchet JM. Enhanced cell penetration of acid-degradable particles functionalized with cell-penetrating peptides. Bioconjug Chem. 2008 Apr; 19(4):876-81. PMID: 18318462.
        View in: PubMed
      64. Almutairi A, Guillaudeu SJ, Berezin MY, Achilefu S, Fréchet JM. Biodegradable pH-sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging. J Am Chem Soc. 2008 Jan 16; 130(2):444-5. PMID: 18088125.
        View in: PubMed
      65. Kanta H, Laprade L, Almutairi A, Pinto I. Suppressor analysis of a histone defect identifies a new function for the hda1 complex in chromosome segregation. Genetics. 2006 May; 173(1):435-50. PMID: 16415367; PMCID: PMC1461434.
      66. Morsy MR, Almutairi A, Gibbons J, Yun SJ, de Los Reyes BG. The OsLti6 genes encoding low-molecular-weight membrane proteins are differentially expressed in rice cultivars with contrasting sensitivity to low temperature. Gene. 2005 Jan 03; 344:171-80. PMID: 15656983.
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      67. Marsella MJ, Yoon K, Almutairi A, Butt SK, Tham FS. Helical sexithiophenes: an experimental and theoretical study implicating the alternating 2,2':3,3' regioisomer as a reliable helical motif. J Am Chem Soc. 2003 Nov 19; 125(46):13928-9. PMID: 14611207.
        View in: PubMed
      68. Mitchell RH, Ward TR, Chen Y, Wang Y, Weerawarna SA, Dibble PW, Marsella MJ, Almutairi A, Wang ZQ. Synthesis and photochromic properties of molecules containing [e]-annelated dihydropyrenes. Two and three way pi-switches based on the dimethyldihydropyrene-metacyclophanediene valence isomerization. J Am Chem Soc. 2003 Mar 12; 125(10):2974-88. PMID: 12617665.
        View in: PubMed
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