Sunil Advani

Title(s)Professor, Radiation Medicine and Applied Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Overview 
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Elucidation and therapeutic exploitation of PAK mediated radioresistance
    NIH/NCI R01CA215081Dec 18, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Elucidation and therapeutic exploitation of PAK mediated radioresistance
    NIH R37CA215081Dec 18, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Developing targeted activatable peptides to amplify radiosensitizer delivery
    NIH R03CA219744Aug 15, 2017 - Jul 31, 2020
    Role: Principal Investigator
    Restricting radiosensitization through ErbB targeted antibody drug conjugates
    NIH R21CA205765Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy. Nat Commun. 2022 07 05; 13(1):3869. Hingorani DV, Allevato MM, Camargo MF, Lesperance J, Quraishi MA, Aguilera J, Franiak-Pietryga I, Scanderbeg DJ, Wang Z, Molinolo AA, Alvarado D, Sharabi AB, Bui JD, Cohen EEW, Adams SR, Gutkind JS, Advani SJ. PMID: 35790753; PMCID: PMC9256669.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    2. A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models. Mol Cancer Ther. 2022 01; 21(1):113-124. Do M, Wu CCN, Sonavane PR, Juarez EF, Adams SR, Ross J, Rodriguez Y Baena A, Patel C, Mesirov JP, Carson DA, Advani SJ, Willert K. PMID: 34667113; PMCID: PMC8742765.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    3. Establishment of Patient-Derived Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response. Clin Cancer Res. 2022 01 01; 28(1):187-200. Yebra M, Bhargava S, Kumar A, Burgoyne AM, Tang CM, Yoon H, Banerjee S, Aguilera J, Cordes T, Sheth V, Noh S, Ustoy R, Li S, Advani SJ, Corless CL, Heinrich MC, Kurzrock R, Lippman SM, Fanta PT, Harismendy O, Metallo C, Sicklick JK. PMID: 34426440; PMCID: PMC8738129.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    4. Tumor Activated Cell Penetrating Peptides to Selectively Deliver Immune Modulatory Drugs. Pharmaceutics. 2021 Mar 10; 13(3). Hingorani DV, Camargo MF, Quraishi MA, Adams SR, Advani SJ. PMID: 33801967; PMCID: PMC8000974.
      View in: PubMed   Mentions: 6  
    5. Redirecting extracellular proteases to molecularly guide radiosensitizing drugs to tumors. Biomaterials. 2020 07; 248:120032. Hingorani DV, Crisp JL, Doan MK, Camargo MF, Quraishi MA, Aguilera J, Gilardi M, Gross LA, Jiang T, Li WT, Ongkeko WM, Cohen EEW, Gutkind JS, Adams SR, Advani SJ. PMID: 32304937; PMCID: PMC7285923.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    6. Precision Chemoradiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability. Mol Cancer Ther. 2020 01; 19(1):157-167. Hingorani DV, Doan MK, Camargo MF, Aguilera J, Song SM, Pizzo D, Scanderbeg DJ, Cohen EEW, Lowy AM, Adams SR, Advani SJ. PMID: 31597712; PMCID: PMC6946877.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    7. An in vitro study for the dosimetric and radiobiological validation of respiratory gating in conventional and hypofractionated radiotherapy of the lung: effect of dose, dose rate, and breathing pattern. Phys Med Biol. 2019 07 04; 64(13):135009. Cerviño LI, Soultan D, Advani SJ, Cornell M, Yock A, Pettersson N, Song WY, Aguilera J, Murphy J, Hoh C, James C, Paravati A, Coope R, Gill B, Moiseenko V. PMID: 31189137.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Radiation-Drug Combinations to Improve Clinical Outcomes and Reduce Normal Tissue Toxicities: Current Challenges and New Approaches: Report of the Symposium Held at the 63rd Annual Meeting of the Radiation Research Society, 15-18 October 2017; Cancun, Mexico. Radiat Res. 2018 10; 190(4):350-360. Falls KC, Sharma RA, Lawrence YR, Amos RA, Advani SJ, Ahmed MM, Vikram B, Coleman CN, Prasanna PG. PMID: 30280985; PMCID: PMC6322391.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    9. A novel 3D-printed phantom insert for 4D PET/CT imaging and simultaneous integrated boost radiotherapy. Med Phys. 2017 Oct; 44(10):5467-5474. Cerviño L, Soultan D, Cornell M, Yock A, Pettersson N, Song WY, Aguilera J, Advani S, Murphy J, Hoh C, James C, Paravati A, Coope R, Gill B, Moiseenko V. PMID: 28766726.
      View in: PubMed   Mentions: 7     Fields:    
    10. Phase I Trial of Intravenous Oncolytic Vaccinia Virus (GL-ONC1) with Cisplatin and Radiotherapy in Patients with Locoregionally Advanced Head and Neck Carcinoma. Clin Cancer Res. 2017 Oct 01; 23(19):5696-5702. Mell LK, Brumund KT, Daniels GA, Advani SJ, Zakeri K, Wright ME, Onyeama SJ, Weisman RA, Sanghvi PR, Martin PJ, Szalay AA. PMID: 28679776.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCellsCTClinical Trials
    11. MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun. 2016 11 25; 7:13597. Wilson R, Espinosa-Diez C, Kanner N, Chatterjee N, Ruhl R, Hipfinger C, Advani SJ, Li J, Khan OF, Franovic A, Weis SM, Kumar S, Coussens LM, Anderson DG, Chen CC, Cheresh DA, Anand S. PMID: 27886180; PMCID: PMC5133658.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    12. Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. Nat Commun. 2016 10 04; 7:13019. Adams SR, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ. PMID: 27698471; PMCID: PMC5059467.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    13. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 2016 Jan; 52:58-65. Yu V, Rahimy M, Korrapati A, Xuan Y, Zou AE, Krishnan AR, Tsui T, Aguilera JA, Advani S, Crotty Alexander LE, Brumund KT, Wang-Rodriguez J, Ongkeko WM. PMID: 26547127; PMCID: PMC4891196.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    14. Kinase-independent role for CRAF-driving tumour radioresistance via CHK2. Nat Commun. 2015 Sep 03; 6:8154. Advani SJ, Camargo MF, Seguin L, Mielgo A, Anand S, Hicks AM, Aguilera J, Franovic A, Weis SM, Cheresh DA. PMID: 26333361; PMCID: PMC4559870.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    15. Clinical and cosmetic outcomes in patients treated with high-dose-rate electronic brachytherapy for nonmelanoma skin cancer. Pract Radiat Oncol. 2015 Nov-Dec; 5(6):e659-64. Paravati AJ, Hawkins PG, Martin AN, Mansy G, Rahn DA, Advani SJ, Hoisak J, Dragojevic I, Martin PJ, Miller CJ, Sanghvi P. PMID: 26432680.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    16. Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma. Oral Oncol. 2015 May; 51(5):470-5. Raju SC, Hauff SJ, Lemieux AJ, Orosco RK, Gross AM, Nguyen LT, Savariar E, Moss W, Whitney M, Cohen EE, Lippman SM, Tsien RY, Ideker T, Advani SJ, Nguyen QT. PMID: 25735654; PMCID: PMC4427339.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 01; 75(7):1376-1387. Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ. PMID: 25681274; PMCID: PMC4458508.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    18. Combination of fractionated irradiation with anti-VEGF expressing vaccinia virus therapy enhances tumor control by simultaneous radiosensitization of tumor associated endothelium. Int J Cancer. 2013 Dec 15; 133(12):2989-99. Buckel L, Advani SJ, Frentzen A, Zhang Q, Yu YA, Chen NG, Ehrig K, Stritzker J, Mundt AJ, Szalay AA. PMID: 23729266.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    19. Preferential replication of systemically delivered oncolytic vaccinia virus in focally irradiated glioma xenografts. Clin Cancer Res. 2012 May 01; 18(9):2579-90. Advani SJ, Buckel L, Chen NG, Scanderbeg DJ, Geissinger U, Zhang Q, Yu YA, Aguilar RJ, Mundt AJ, Szalay AA. PMID: 22379115.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    20. A MEK-independent role for CRAF in mitosis and tumor progression. Nat Med. 2011 Nov 13; 17(12):1641-5. Mielgo A, Seguin L, Huang M, Camargo MF, Anand S, Franovic A, Weis SM, Advani SJ, Murphy EA, Cheresh DA. PMID: 22081024; PMCID: PMC3233644.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    21. DNA damage response and repair: insights into strategies for radiation sensitization of gliomas. Future Oncol. 2011 Nov; 7(11):1335-46. Kesari S, Advani SJ, Lawson JD, Kahle KT, Ng K, Carter B, Chen CC. PMID: 22044206; PMCID: PMC3236247.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    22. Increased oncolytic efficacy for high-grade gliomas by optimal integration of ionizing radiation into the replicative cycle of HSV-1. Gene Ther. 2011 Nov; 18(11):1098-102. Advani SJ, Markert JM, Sood RF, Samuel S, Gillespie GY, Shao MY, Roizman B, Weichselbaum RR. PMID: 21544094; PMCID: PMC8670556.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    23. Enhancing radiotherapy with genetically engineered viruses. J Clin Oncol. 2007 Sep 10; 25(26):4090-5. Advani SJ, Weichselbaum RR, Chmura SJ. PMID: 17827458.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    24. ReVOLT: radiation-enhanced viral oncolytic therapy. Int J Radiat Oncol Biol Phys. 2006 Nov 01; 66(3):637-46. Advani SJ, Mezhir JJ, Roizman B, Weichselbaum RR. PMID: 17011442.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    25. Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses. Cancer Res. 2005 Oct 15; 65(20):9479-84. Mezhir JJ, Advani SJ, Smith KD, Darga TE, Poon AP, Schmidt H, Posner MC, Roizman B, Weichselbaum RR. PMID: 16230412.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    26. The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1. J Virol. 2005 Jun; 79(11):6757-62. Durand LO, Advani SJ, Poon AP, Roizman B. PMID: 15890914; PMCID: PMC1112163.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    27. Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1. J Virol. 2003 Nov; 77(22):11927-32. Advani SJ, Durand LO, Weichselbaum RR, Roizman B. PMID: 14581529; PMCID: PMC254286.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. Sustained inhibition of experimental neointimal hyperplasia with a genetically modified herpes simplex virus. J Vasc Surg. 2003 Jun; 37(6):1294-300. Curi MA, Skelly CL, Meyerson SL, Baldwin ZK, Balasubramanian V, Advani SJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB. PMID: 12764278.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    29. Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4825-30. Advani SJ, Weichselbaum RR, Roizman B. PMID: 12665617; PMCID: PMC153640.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    30. Prospects for viral-based strategies enhancing the anti-tumor effects of ionizing radiation. Semin Radiat Oncol. 2001 Oct; 11(4):338-45. Chmura SJ, Gupta N, Advani SJ, Kufe DW, Weichselbaum RR. PMID: 11677658.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    31. Role of cyclin D3 in the biology of herpes simplex virus 1 ICPO. J Virol. 2001 Feb; 75(4):1888-98. Van Sant C, Lopez P, Advani SJ, Roizman B. PMID: 11160688; PMCID: PMC115135.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    32. Molecular targeting of gene therapy and radiotherapy. Acta Oncol. 2001; 40(6):735-8. Weichselbaum RR, Kufe DW, Advani SJ, Roizman B. PMID: 11765068.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. The role of cdc2 in the expression of herpes simplex virus genes. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10996-1001. Advani SJ, Weichselbaum RR, Roizman B. PMID: 10995483; PMCID: PMC27137.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    34. E2F proteins are posttranslationally modified concomitantly with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1. J Virol. 2000 Sep; 74(17):7842-50. Advani SJ, Weichselbaum RR, Roizman B. PMID: 10933691; PMCID: PMC112314.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    35. The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes. J Virol. 2000 Jan; 74(1):8-15. Advani SJ, Brandimarti R, Weichselbaum RR, Roizman B. PMID: 10590085; PMCID: PMC111507.
      View in: PubMed   Mentions: 53     Fields:    Translation:Cells
    36. Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus 1. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):12062-7. Khodarev NN, Advani SJ, Gupta N, Roizman B, Weichselbaum RR. PMID: 10518576; PMCID: PMC18412.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    37. Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors. Cancer Res. 1999 May 01; 59(9):2055-8. Advani SJ, Chung SM, Yan SY, Gillespie GY, Markert JM, Whitley RJ, Roizman B, Weichselbaum RR. PMID: 10232586.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    38. Strategies for enhancing viral-based gene therapy using ionizing radiation. Radiat Oncol Investig. 1999; 7(5):261-9. Chmura SJ, Advani SJ, Kufe DW, Weichselbaum RR. PMID: 10580895.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    39. Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors. Gene Ther. 1998 Feb; 5(2):160-5. Advani SJ, Sibley GS, Song PY, Hallahan DE, Kataoka Y, Roizman B, Weichselbaum RR. PMID: 9578834.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    40. Radiogenetic therapy: on the interaction of viral therapy and ionizing radiation for improving local control of tumors. Semin Oncol. 1997 Dec; 24(6):633-8. Advani SJ, Chmura SJ, Weichselbaum RR. PMID: 9422260.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    With one click, see people who:

    Mentor Faculty

    Run Clinical Trials

    See more options in the Advanced Search tab

    Sunil's Networks
    Concepts (251)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (41)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSD Profiles is managed by the UC San Diego Altman Clinical and Translational Research Institute (ACTRI).
    This site is running Profiles RNS version UCSF-v3.1.0-3-g1ef1264b on PROFILES-PWEB03. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California