Mohit Jain

Title(s)	Clinical Professor, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

School of Medicine

M.D., Ph.D.

Boston University

Overview

Interests

Human Biology, Metabolic Biochemistry, Integrative Biology, Mass Spectrometry, Metabolomics

Websites

	Department of Pharmacology
	Jain Lab

Research

Research Activities and Funding

Bioactive Metabolites Modulate Immune-Related Adverse Events in Cancer Immunotherapy
NIH R01CA256133Jul 8, 2021 - Jun 30, 2026
Role: Co-Principal Investigator

Mapping the Plasma Exposome and its Association with Human Cardiovascular Disease
NIH R01ES027595Feb 1, 2017 - Jan 31, 2022
Role: Principal Investigator

Mapping metabolic activities in stem cell-derived models of human cardiomyopathy
NIH R03HL133720Aug 15, 2016 - Jul 31, 2018
Role: Principal Investigator

Reactive electrophiles in human aging and longevity
NIH R03AG053287Aug 1, 2016 - Apr 30, 2018
Role: Principal Investigator

RapidFire mass spectrometry system
NIH S10OD020025Apr 17, 2015 - Apr 16, 2016
Role: Principal Investigator

A systems approach to metabolic dysregulation in the heart
NIH K08HL107451Apr 22, 2011 - Mar 31, 2016
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders. Sci Adv. 2024 Feb 09; 10(6):eadj5661. Lawrence ES, Gu W, Bohlender RJ, Anza-Ramirez C, Cole AM, Yu JJ, Hu H, Heinrich EC, O'Brien KA, Vasquez CA, Cowan QT, Bruck PT, Mercader K, Alotaibi M, Long T, Hall JE, Moya EA, Bauk MA, Reeves JJ, Kong MC, Salem RM, Vizcardo-Galindo G, Macarlupu JL, Figueroa-Mujíca R, Bermudez D, Corante N, Gaio E, Fox KP, Salomaa V, Havulinna AS, Murray AJ, Malhotra A, Powel FL, Jain M, Komor AC, Cavalleri GL, Huff CD, Villafuerte FC, Simonson TS. PMID: 38335297; PMCID: PMC10857371.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Humans
Pulmonary primary oxysterol and bile acid synthesis as a predictor of outcomes in pulmonary arterial hypertension. bioRxiv. 2024 Jan 23. Alotaibi M, Harvey LD, Nichols WC, Pauciulo MW, Hemnes A, Long T, Watrous JD, Begzati A, Tuomilehto J, Havulinna AS, Niiranen TJ, Jousilahti P, Salomaa V, Bertero T, Kim NH, Desai AA, Malhotra A, Yuan JX, Cheng S, Chan SY, Jain M. PMID: 38328113; PMCID: PMC10849469.

View in: PubMed Mentions:
Author Correction: Greengenes2 unifies microbial data in a single reference tree. Nat Biotechnol. 2023 Oct 18. McDonald D, Jiang Y, Balaban M, Cantrell K, Zhu Q, Gonzalez A, Morton JT, Nicolaou G, Parks DH, Karst SM, Albertsen M, Hugenholtz P, DeSantis T, Song SJ, Bartko A, Havulinna AS, Jousilahti P, Cheng S, Inouye M, Niiranen T, Jain M, Salomaa V, Lahti L, Mirarab S, Knight R. PMID: 37853258.

View in: PubMed Mentions: 1 Fields:
Bio Biotechnology
Metabolic programs of T cell tissue residency empower tumour immunity. Nature. 2023 Sep; 621(7977):179-187. Reina-Campos M, Heeg M, Kennewick K, Mathews IT, Galletti G, Luna V, Nguyen Q, Huang H, Milner JJ, Hu KH, Vichaidit A, Santillano N, Boland BS, Chang JT, Jain M, Sharma S, Krummel MF, Chi H, Bensinger SJ, Goldrath AW. PMID: 37648857.

View in: PubMed Mentions: 7 Fields:
Sci Science
Translation:Humans Animals Cells
Greengenes2 unifies microbial data in a single reference tree. Nat Biotechnol. 2023 Jul 27. McDonald D, Jiang Y, Balaban M, Cantrell K, Zhu Q, Gonzalez A, Morton JT, Nicolaou G, Parks DH, Karst SM, Albertsen M, Hugenholtz P, DeSantis T, Song SJ, Bartko A, Havulinna AS, Jousilahti P, Cheng S, Inouye M, Niiranen T, Jain M, Salomaa V, Lahti L, Mirarab S, Knight R. PMID: 37500913; PMCID: PMC10818020.

View in: PubMed Mentions: 13 Fields:
Bio Biotechnology
Deriving Convergent and Divergent Metabolomic Correlates of Pulmonary Arterial Hypertension. Metabolites. 2023 Jun 28; 13(7). Alotaibi M, Liu Y, Magalang GA, Kwan AC, Ebinger JE, Nichols WC, Pauciulo MW, Jain M, Cheng S. PMID: 37512509; PMCID: PMC10386502.

View in: PubMed Mentions:
Reconstructing the landscape of gut microbial species across 29,000 diverse individuals. Nucleic Acids Res. 2023 05 22; 51(9):4178-4190. Segota I, Watrous JD, Kantz ED, Nallamshetty S, Tiwari S, Cheng S, Jain M, Long T. PMID: 37070603; PMCID: PMC10201371.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Humans Cells
Sex-related Differences in Eicosanoid Levels in Chronic Thromboembolic Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 02; 68(2):228-231. Alotaibi M, Fernandes T, Tang AB, Magalang GA, Watrous JD, Long T, Pretorius V, Madani M, Kim NH, Jain M, Cheng S. PMID: 36722774; PMCID: PMC9986560.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans
Regulation of Human Endogenous Metabolites by Drug Transporters and Drug Metabolizing Enzymes: An Analysis of Targeted SNP-Metabolite Associations. Metabolites. 2023 Jan 24; 13(2). Granados JC, Watrous JD, Long T, Rosenthal SB, Cheng S, Jain M, Nigam SK. PMID: 36837791; PMCID: PMC9958903.

View in: PubMed Mentions:
Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity. Chest. 2023 01; 163(1):204-215. Alotaibi M, Shao J, Pauciulo MW, Nichols WC, Hemnes AR, Malhotra A, Kim NH, Yuan JX, Fernandes T, Kerr KM, Alshawabkeh L, Desai AA, Bujor AM, Lafyatis R, Watrous JD, Long T, Cheng S, Chan SY, Jain M. PMID: 36087794; PMCID: PMC9899641.

View in: PubMed Mentions: 4 Fields:
Pul Pulmonary Medicine
Translation:Humans
Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun. 2022 07 27; 13(1):4346. Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. PMID: 35896521; PMCID: PMC9329322.

View in: PubMed Mentions: Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells PHPublic Health
Efficient computation of Faith's phylogenetic diversity with applications in characterizing microbiomes. Genome Res. 2021 11; 31(11):2131-2137. Armstrong G, Cantrell K, Huang S, McDonald D, Haiminen N, Carrieri AP, Zhu Q, Gonzalez A, McGrath I, Beck KL, Hakim D, Havulinna AS, Méric G, Niiranen T, Lahti L, Salomaa V, Jain M, Inouye M, Swafford AD, Kim HC, Parida L, Vázquez-Baeza Y, Knight R. PMID: 34479875; PMCID: PMC8559715.

View in: PubMed Mentions: 6 Fields:
Gen Genetics
Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity. Sci Rep. 2021 Jul 06; 11(1):13866. Sapp V, Aguirre A, Mainkar G, Ding J, Adler E, Liao R, Sharma S, Jain M. PMID: 34230586; PMCID: PMC8260754.

View in: PubMed Mentions: 10 Fields:
Sci Science
Translation:Humans Cells
Nontargeted mass spectrometry of dried blood spots for interrogation of the human circulating metabolome. J Mass Spectrom. 2021 May 27; 56(8):e4772. Ward C, Nallamshetty S, Watrous JD, Acres E, Long T, Mathews IT, Sharma S, Cheng S, Imam F, Jain M. PMID: 34240506; PMCID: PMC8626523.

View in: PubMed Mentions: Fields:
Che Chemistry Techniques
Imbalance Between Omega-6- and Omega-3-Derived Bioactive Lipids in Arthritis in Older Adults. J Gerontol A Biol Sci Med Sci. 2021 02 25; 76(3):415-425. Coras R, Pedersen B, Narasimhan R, Brandy A, Mateo L, Prior-Español A, Kavanaugh A, Armando AM, Jain M, Quehenberger O, Martínez-Morillo M, Guma M. PMID: 32361743; PMCID: PMC7907486.

View in: PubMed Mentions: 5 Fields:
Ger Geriatrics
Translation:Humans
Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition. Genet Med. 2021 03; 23(3):524-533. Ghosh SG, Lee S, Fabunan R, Chai G, Zaki MS, Abdel-Salam G, Sultan T, Ben-Omran T, Alvi JR, McEvoy-Venneri J, Stanley V, Patel A, Ross D, Ding J, Jain M, Pan D, Lübbert P, Kammerer B, Wiedemann N, Verhoeven-Duif NM, Jans JJ, Murphy D, Toosi MB, Ashrafzadeh F, Imannezhad S, Karimiani EG, Ibrahim K, Waters ER, Maroofian R, Gleeson JG. PMID: 33188300.

View in: PubMed Mentions: 12 Fields:
Gen Genetics
Translation:Humans Animals
Metabolomic profiles associated with a mouse model of antipsychotic-induced food intake and weight gain. Sci Rep. 2020 10 29; 10(1):18581. Zapata RC, Rosenthal SB, Fisch K, Dao K, Jain M, Osborn O. PMID: 33122657; PMCID: PMC7596057.

View in: PubMed Mentions: 5 Fields:
Sci Science
Translation:Animals
Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020 10; 2(10):1034-1045. Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. PMID: 32839596; PMCID: PMC8018782.

View in: PubMed Mentions: 85 Fields:
Met Metabolism
Translation:Humans Animals Cells
Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes. N Engl J Med. 2020 08 20; 383(8):721-732. Yoshino M, Kayser BD, Yoshino J, Stein RI, Reeds D, Eagon JC, Eckhouse SR, Watrous JD, Jain M, Knight R, Schechtman K, Patterson BW, Klein S. PMID: 32813948; PMCID: PMC7456610.

View in: PubMed Mentions: 87 Fields:
Med Medicine (General)
Translation:Humans CTClinical Trials
Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):723-733.e6. Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. PMID: 31932164; PMCID: PMC7065454.

View in: PubMed Mentions: 73 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Cells
HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):709-722.e7. Ye Q, Lau RK, Mathews IT, Birkholz EA, Watrous JD, Azimi CS, Pogliano J, Jain M, Corbett KD. PMID: 31932165; PMCID: PMC7036143.

View in: PubMed Mentions: 62 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Cells
Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. Diabetes. 2019 07; 68(7):1415-1426. Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. PMID: 31010956; PMCID: PMC6609982.

View in: PubMed Mentions: 16 Fields:
End Endocrinology
Translation:Animals Cells
Pro- and anti-inflammatory eicosanoids in psoriatic arthritis. Metabolomics. 2019 04 19; 15(4):65. Coras R, Kavanaugh A, Boyd T, Huynh Q, Pedersen B, Armando AM, Dahlberg-Wright S, Marsal S, Jain M, Paravar T, Quehenberger O, Guma M. PMID: 31004236; PMCID: PMC6533065.

View in: PubMed Mentions: 29 Fields:
Met Metabolism
Translation:Humans
Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins. Cell Chem Biol. 2019 03 21; 26(3):433-442.e4. Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M. PMID: 30661990; PMCID: PMC6636917.

View in: PubMed Mentions: 42 Fields:
Bio Biochemistry Bio Biology Che Chemistry
Translation:Humans
Choline metabolite, trimethylamine N-oxide (TMAO), is associated with inflammation in psoriatic arthritis. Clin Exp Rheumatol. 2019 May-Jun; 37(3):481-484. Coras R, Kavanaugh A, Boyd T, Huynh D, Lagerborg KA, Xu YJ, Rosenthal SB, Jain M, Guma M. PMID: 30620278; PMCID: PMC6529247.

View in: PubMed Mentions: 25 Fields:
Rhe Rheumatology
Translation:Humans
High-Throughput Measure of Bioactive Lipids Using Non-targeted Mass Spectrometry. Methods Mol Biol. 2019; 1862:17-35. Lagerborg KA, Watrous JD, Cheng S, Jain M. PMID: 30315457.

View in: PubMed Mentions: 25 Fields:
Mol Molecular Biology
Translation:Humans
Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function. J Biol Chem. 2018 05 25; 293(21):8182-8195. Suarez J, Cividini F, Scott BT, Lehmann K, Diaz-Juarez J, Diemer T, Dai A, Suarez JA, Jain M, Dillmann WH. PMID: 29626093; PMCID: PMC5971443.

View in: PubMed Mentions: 47 Fields:
Bio Biochemistry
Translation:Animals Cells
Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. Circulation. 2017 Oct 03; 136(14):1315-1330. Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain MK, Subramaniam S, Shyy JY. PMID: 28794002; PMCID: PMC5741092.

View in: PubMed Mentions: 49 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Animals
Visualization, Quantification, and Alignment of Spectral Drift in Population Scale Untargeted Metabolomics Data. Anal Chem. 2017 02 07; 89(3):1399-1404. Watrous JD, Henglin M, Claggett B, Lehmann KA, Larson MG, Cheng S, Jain M. PMID: 28208263; PMCID: PMC5455767.

View in: PubMed Mentions: 20 Fields:
Che Chemistry Techniques
Translation:Humans
Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy. Physiology (Bethesda). 2016 07; 31(4):294-9. Sapp V, Jain M, Liao R. PMID: 27252164; PMCID: PMC6195664.

View in: PubMed Mentions: 6 Fields:
Phy Physiology
Translation:Humans Animals