Geoffrey Chang

Title(s)	Professor, School of Pharmacy and Pharmaceutical Science
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

Ph.D.

University of Pennsylvania

Overview

Websites

Department of Pharmacology

Research

Research Activities and Funding

Development of low-cost, field-ready nanobodies against snake venom
NIH R41GM146314Sep 15, 2021 - Sep 14, 2022
Role: Co-Principal Investigator

TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation
NIH R01NS121604Apr 1, 2021 - Mar 31, 2026
Role: Co-Principal Investigator

Nanobody inhibitors of proton-sensing G protein-coupled receptors
NIH R03TR003639Apr 1, 2021 - Mar 31, 2022
Role: Principal Investigator

Down syndrome, early cataracts, eye diseases, and beta-amyloid conformers
NIH R21EY031277Sep 30, 2019 - Aug 31, 2021
Role: Principal Investigator

Identity, mechanisms and early life impacts of transporter interfering compounds
NIH R01ES027921Jun 1, 2018 - May 31, 2023
Role: Co-Principal Investigator

Structure-based optimization of a novel pharmacological chaperone therapy for MPSIIIC
NIH R41HD092110Sep 15, 2017 - Aug 31, 2020
Role: Co-Principal Investigator

A novel platform for genetically-encoded optical neuropeptide sensors (NEONS)
NIH R21EY028399Sep 1, 2017 - Aug 31, 2020
Role: Co-Principal Investigator

Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease
NIH R01NS087611May 1, 2014 - Apr 30, 2020
Role: Principal Investigator

Structure and function of ABC transporters to understand persistence of global ma
NIH R01ES021985Sep 24, 2012 - Jul 31, 2017
Role: Principal Investigator

Molecular Organization of the Organic Cation-Proton Exchanger, MATE1
NIH R01DK080801Sep 30, 2010 - Jul 31, 2017
Role: Principal Investigator

TransportPDB: Center for the X-ray Structure Determination of Human Transporters
NIH U54GM094610Sep 30, 2010 - Jun 30, 2015
Role: Principal Investigator

Structural biology and high resolution studies of P-glycoprotein
NIH R01GM094367Sep 20, 2010 - Aug 31, 2015
Role: Principal Investigator

Affinity maturation via in vitro evolution at the lab bench-top
NIH R01GM094955Sep 1, 2010 - Aug 31, 2016
Role: Principal Investigator

Inhibition of Malaria Chloroquine Resistance Transporters
NIH R56AI090832Jun 21, 2010 - May 31, 2012
Role: Principal Investigator

Crystallography of MATE Transporters
NIH R01GM070480Feb 1, 2005 - Jan 31, 2011
Role: Principal Investigator

JCIMPT-Complexes
NIH P50GM073197Sep 24, 2004 - Dec 31, 2014
Role: Co-Investigator

X-ray Structures of Small MDR Efflux Pumps
NIH R01GM067644Jan 1, 2003 - Dec 31, 2007
Role: Principal Investigator

Crystallography of Multi-Drug Resistant MFS Transporters
NIH R21GM065798Sep 24, 2001 - Aug 31, 2003
Role: Principal Investigator

Structural Biology and Inhibition of MDR ABC Transporters
NIH R01GM061905Sep 1, 2000 - Jun 30, 2011
Role: Principal Investigator

Molecular Organization of Renal and Hepatic Organic Cation Transporters
NIH R01DK058251Aug 15, 2000 - Jul 31, 2018
Role: Principal Investigator

HIGH RESOLUTION STRUCTURE OF THE POTASSIUM ION CHANNEL
NIH F32GM018486Jan 7, 1997
Role: Principal Investigator

BioCARS: A Synchroton Structural Biology Resource
NIH P41RR007707Sep 15, 1992 - Jul 31, 2013
Role: Co-Investigator

A Synchroton Radiation Structural Biology Resource
NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
Role: Co-Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Computational models in the service of X-ray and cryo-electron microscopy structure determination. Proteins. 2021 12; 89(12):1633-1646. Kryshtafovych A, Moult J, Albrecht R, Chang GA, Chao K, Fraser A, Greenfield J, Hartmann MD, Herzberg O, Josts I, Leiman PG, Linden SB, Lupas AN, Nelson DC, Rees SD, Shang X, Sokolova ML, Tidow H, AlphaFold2 team. PMID: 34449113; PMCID: PMC8616789.

View in: PubMed Mentions: 21 Fields:
Bio Biochemistry
Translation:Cells
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nat Struct Mol Biol. 2013 Feb; 20(2):135-8. Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A. PMID: 23381628; PMCID: PMC3645303.

View in: PubMed Mentions: 31 Fields:
Mol Molecular Biology
Translation:Humans Cells