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    David Feifel

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentPsychiatry
    Address9500 Gilman Drive #0957
    CA La Jolla 92093
    Phone619-543-8747
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Feifel D. Breaking Sad: Unleashing the Breakthrough Potential of Ketamine's Rapid Antidepressant Effects. Drug Dev Res. 2016 Nov 26. PMID: 27888525.
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      2. Shilling PD, Feifel D. Potential of Oxytocin in the Treatment of Schizophrenia. CNS Drugs. 2016 Mar; 30(3):193-208. PMID: 26895254.
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      3. Hadas I, Gal R, Bokovza L, Meiran N, Feifel D, Zangen A. Exposure to salient, dynamic sensory stimuli during development increases distractibility in adulthood. Sci Rep. 2016 Feb 17; 6:21129. PMID: 26882890; PMCID: PMC4756326.
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        View in: PubMed Central
      4. Feifel D, Shilling PD, Fazlinejad AA, Melendez G. Antipsychotic drug-like facilitation of latent inhibition by a brain-penetrating neurotensin-1 receptor agonist. J Psychopharmacol. 2016 Mar; 30(3):312-7. PMID: 26783230.
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      5. Singh F, Nunag J, Muldoon G, Cadenhead KS, Pineda JA, Feifel D. Effects of intranasal oxytocin on neural processing within a socially relevant neural circuit. Eur Neuropsychopharmacol. 2016 Mar; 26(3):626-30. PMID: 26727038.
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      6. Feifel D, Shilling PD, MacDonald K. A Review of Oxytocin's Effects on the Positive, Negative, and Cognitive Domains of Schizophrenia. Biol Psychiatry. 2016 Feb 1; 79(3):222-33. PMID: 26410353.
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      7. Leuchter AF, Cook IA, Feifel D, Goethe JW, Husain M, Carpenter LL, Thase ME, Krystal AD, Philip NS, Bhati MT, Burke WJ, Howland RH, Sheline YI, Aaronson ST, Iosifescu DV, O'Reardon JP, Gilmer WS, Jain R, Burgoyne KS, Phillips B, Manberg PJ, Massaro J, Hunter AM, Lisanby SH, George MS. Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression. Brain Stimul. 2015 Jul-Aug; 8(4):787-94. PMID: 26143022.
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      8. Acheson DT, Feifel D, Kamenski M, Mckinney R, Risbrough VB. Intranasal oxytocin administration prior to exposure therapy for arachnophobia impedes treatment response. Depress Anxiety. 2015 Jun; 32(6):400-7. PMID: 25826649.
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      9. Feifel D, Shilling PD, Hillman J, Maisel M, Winfield J, Melendez G. Peripherally administered oxytocin modulates latent inhibition in a manner consistent with antipsychotic drugs. Behav Brain Res. 2015 Feb 1; 278:424-8. PMID: 25447298.
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      10. Keiser AA, Matazel KS, Esser MK, Feifel D, Prus AJ. Systemic administration of the neurotensin NTS1-receptor agonist PD149163 improves performance on a memory task in naturally deficient male Brown Norway rats. Exp Clin Psychopharmacol. 2014 Dec; 22(6):541-7. PMID: 25222546.
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      11. MacDonald K, Feifel D. Oxytocin?s role in anxiety: A critical appraisal. Brain Res. 2014 Sep 11; 1580:22-56. PMID: 24468203.
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      12. Singh F, Feifel D. Developing Research Domain Criteria (RDoC) to improve diagnosis and treatment of social deficits in psychiatric disorders: The Mirror Neuron System as a model. Schizophr Res. 2013 Dec; 151(1-3):293-4. PMID: 24094678.
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      13. Wilson MP, Macdonald K, Vilke GM, Ronquillo L, Feifel D. Intramuscular ziprasidone: influence of alcohol and benzodiazepines on vital signs in the emergency setting. J Emerg Med. 2013 Dec; 45(6):901-8. PMID: 24071032.
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      14. Berquist Ii MD, Mooney-Leber SM, Feifel D, Prus AJ. Assessment of attention in male and female Brattleboro rats using a self-paced five-choice serial reaction time task. Brain Res. 2013 Nov 6; 1537:174-9. PMID: 24055104.
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      15. Macdonald K, Feifel D, Brüne M, Lamb K, Wilson MP, Golshan S, Macdonald T. Not disappointed by anxiety: A reply to Cardoso and Ellenbogen's commentary "Oxytocin and psychotherapy: Keeping context and person in mind". Psychoneuroendocrinology. 2013 Dec; 38(12):3173-5. PMID: 24035602.
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      16. Feifel D. Limited evidence that benzodiazepines are beneficial in the treatment of disturbed behaviour. Evid Based Ment Health. 2013 Nov; 16(4):111. PMID: 23956251.
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      17. Macdonald K, Macdonald TM, Brüne M, Lamb K, Wilson MP, Golshan S, Feifel D. Oxytocin and psychotherapy: A pilot study of its physiological, behavioral and subjective effects in males with depression. Psychoneuroendocrinology. 2013 Dec; 38(12):2831-43. PMID: 23810433.
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      18. Acheson D, Feifel D, de Wilde S, McKinney R, Lohr J, Risbrough V. The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample. Psychopharmacology (Berl). 2013 Sep; 229(1):199-208. PMID: 23644911.
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      19. Feifel D, Wilson MP, Pepper D, Currier GW, Holloman G. In reply:. West J Emerg Med. 2012 Dec; 13(6):536-7. PMID: 23875056.
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      20. Feifel D, Macdonald K, Cobb P, Minassian A. Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia. Schizophr Res. 2012 Aug; 139(1-3):207-10. PMID: 22682705.
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      21. MacDonald K, Wilson M, Minassian A, Vilke GM, Becker O, Tallian K, Cobb P, Perez R, Galangue B, Feifel D. A naturalistic study of intramuscular haloperidol versus intramuscular olanzapine for the management of acute agitation. J Clin Psychopharmacol. 2012 Jun; 32(3):317-22. PMID: 22544013.
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      22. Arnold VK, Feifel D, Earl CQ, Yang R, Adler LA. A 9-week, randomized, double-blind, placebo-controlled, parallel-group, dose-finding study to evaluate the efficacy and safety of modafinil as treatment for adults with ADHD. J Atten Disord. 2014 Feb; 18(2):133-44. PMID: 22617860.
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      23. MacDonald K, Feifel D. Dramatic improvement in sexual function induced by intranasal oxytocin. J Sex Med. 2012 May; 9(5):1407-10. PMID: 22458365.
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      24. Feifel D. Oxytocin as a potential therapeutic target for schizophrenia and other neuropsychiatric conditions. Neuropsychopharmacology. 2012 Jan; 37(1):304-5. PMID: 22157870.
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      25. Macdonald K, Feifel D. Oxytocin in schizophrenia: a review of evidence for its therapeutic effects. Acta Neuropsychiatr. 2012 Jun; 24(3):130-46. PMID: 22736892.
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      26. Feifel D, Shilling PD, Belcher AM. The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating. Eur Neuropsychopharmacol. 2012 May; 22(5):374-8. PMID: 21962914.
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      27. Allen MH, Feifel D, Lesem MD, Zimbroff DL, Ross R, Munzar P, Spyker DA, Cassella JV. Efficacy and safety of loxapine for inhalation in the treatment of agitation in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2011 Oct; 72(10):1313-21. PMID: 21294997.
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      28. Apostol G, Abi-Saab W, Kratochvil CJ, Adler LA, Robieson WZ, Gault LM, Pritchett YL, Feifel D, Collins MA, Saltarelli MD. Efficacy and safety of the novel a4ß2 neuronal nicotinic receptor partial agonist ABT-089 in adults with attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled crossover study. Psychopharmacology (Berl). 2012 Feb; 219(3):715-25. PMID: 21748252.
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      29. Wilson MP, MacDonald K, Vilke GM, Feifel D. A comparison of the safety of olanzapine and haloperidol in combination with benzodiazepines in emergency department patients with acute agitation. J Emerg Med. 2012 Nov; 43(5):790-7. PMID: 21601409.
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      30. Feifel D, Shilling PD, Melendez G. Clozapine and PD149163 elevate prepulse inhibition in Brown Norway rats. Behav Neurosci. 2011 Apr; 125(2):268-72. PMID: 21463026.
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      31. Feifel D. Is oxytocin a promising treatment for schizophrenia? Expert Rev Neurother. 2011 Feb; 11(2):157-9. PMID: 21306203.
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      32. Feifel D, Galangue B, Macdonald K, Cobb P, Dinca A, Becker O, Cooper J, Hadley A. A Naturalistic, Single-blind Comparison of Rapid Dose Administration of Divalproex ER Versus Quetiapine in Patients with Acute Bipolar Mania. Innov Clin Neurosci. 2011 Jan; 8(1):29-35. PMID: 21311705.
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      33. Lesem MD, Tran-Johnson TK, Riesenberg RA, Feifel D, Allen MH, Fishman R, Spyker DA, Kehne JH, Cassella JV. Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine. Br J Psychiatry. 2011 Jan; 198(1):51-8. PMID: 21200077.
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      34. Feifel D, Shilling PD, Melendez G. Further characterization of the predictive validity of the Brattleboro rat model for antipsychotic efficacy. J Psychopharmacol. 2011 Jun; 25(6):836-41. PMID: 21106605.
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      35. Feifel D, Shilling PD. Promise and pitfalls of animal models of schizophrenia. Curr Psychiatry Rep. 2010 Aug; 12(4):327-34. PMID: 20544314.
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      36. Feifel D, Macdonald K, Nguyen A, Cobb P, Warlan H, Galangue B, Minassian A, Becker O, Cooper J, Perry W, Lefebvre M, Gonzales J, Hadley A. Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients. Biol Psychiatry. 2010 Oct 1; 68(7):678-80. PMID: 20615494.
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      37. MacDonald K, Wilson MP, Minassian A, Vilke GM, Perez R, Cobb P, Tallian K, Becker O, Feifel D. A retrospective analysis of intramuscular haloperidol and intramuscular olanzapine in the treatment of agitation in drug- and alcohol-using patients. Gen Hosp Psychiatry. 2010 Jul-Aug; 32(4):443-5. PMID: 20633750.
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      38. Wilson MP, MacDonald K, Vilke GM, Feifel D. Potential complications of combining intramuscular olanzapine with benzodiazepines in emergency department patients. J Emerg Med. 2012 Nov; 43(5):889-96. PMID: 20542400.
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      39. Feifel D, Pang Z, Pang Z, Shilling PD, Melendez G, Schreiber R, Button D. Effects of neurotensin-2 receptor deletion on sensorimotor gating and locomotor activity. Behav Brain Res. 2010 Oct 15; 212(2):174-8. PMID: 20399236.
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      40. Feifel D. The Use of Placebo-Controlled Clinical Trials for the Approval of Psychiatric Drugs: Part II-Ethical Considerations Related to the Individual Participant. Psychiatry (Edgmont). 2009 Dec; 6(12):19-25. PMID: 20104288.
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      41. Feifel D, Goldenberg J, Melendez G, Shilling PD. The acute and subchronic effects of a brain-penetrating, neurotensin-1 receptor agonist on feeding, body weight and temperature. Neuropharmacology. 2010 Jan; 58(1):195-8. PMID: 19596358.
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      42. Feifel D, Pang Z, Shilling PD, Melendez G, Schreiber R, Button D. Sensorimotor gating in neurotensin-1 receptor null mice. Neuropharmacology. 2010 Jan; 58(1):173-8. PMID: 19596359.
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      43. Cutler AJ, Montgomery SA, Feifel D, Lazarus A, Aström M, Brecher M. Extended release quetiapine fumarate monotherapy in major depressive disorder: a placebo- and duloxetine-controlled study. J Clin Psychiatry. 2009 Apr; 70(4):526-39. PMID: 19358790.
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      44. Feifel D, Mexal S, Melendez G, Liu PY, Goldenberg JR, Shilling PD. The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. Neuropsychopharmacology. 2009 Jul; 34(8):2011-8. PMID: 19322170.
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      45. Feifel D. The use of placebo-controlled clinical trials for the approval of psychiatric drugs: part I-statistics and the case for the "greater good". Psychiatry (Edgmont). 2009 Mar; 6(3):41-3. PMID: 19724754.
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      46. Shilling PD, Feifel D. The neurotensin-1 receptor agonist PD149163 blocks fear-potentiated startle. Pharmacol Biochem Behav. 2008 Oct; 90(4):748-52. PMID: 18577396.
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      47. Feifel D. Commentary: why diagnose and treat ADHD in adults? Postgrad Med. 2008 Sep; 120(3):13-5. PMID: 18824821.
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      48. Feifel D, MacDonald K. Attention-deficit/hyperactivity disorder in adults: recognition and diagnosis of this often-overlooked condition. Postgrad Med. 2008 Sep; 120(3):39-47. PMID: 18824824.
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      49. Feifel D. Transforming the psychiatric inpatient unit from short-term pseudo-asylum care to state-of-the-art treatment setting. Psychiatry (Edgmont). 2008 Sep; 5(9):47-50. PMID: 19727261.
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      50. Feifel D, Minassian A, Perry W. Prepulse inhibition of startle in adults with ADHD. J Psychiatr Res. 2009 Jan; 43(4):484-9. PMID: 18674783.
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      51. Feifel D, Melendez G, Murray RJ, Tina Tran DN, Rullan MA, Shilling PD. The reversal of amphetamine-induced locomotor activation by a selective neurotensin-1 receptor agonist does not exhibit tolerance. Psychopharmacology (Berl). 2008 Oct; 200(2):197-203. PMID: 18568338.
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      52. Camacho A, Ng B, Galangue B, Feifel D. Use of risperidone long-acting injectable in a rural border community clinic in southern california. Psychiatry (Edgmont). 2008 Jun; 5(6):43-9. PMID: 19727284.
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      53. Feifel D. More depressing news on antidepressants: should we panic? Psychiatry (Edgmont). 2008 Apr; 5(4):35-6. PMID: 19727307.
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      54. Cascade EF, Kalali AH, Feifel D. Treatment of autistic children. Psychiatry (Edgmont). 2008 Feb; 5(2):35-7. PMID: 19727292.
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      55. Feifel D. ADHD in adults: the invisible rhinoceros. Psychiatry (Edgmont). 2007 Dec; 4(12):60-2. PMID: 20436766.
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      56. Cascade EF, Kalali AH, Feifel D. Daytrana: the first year. Psychiatry (Edgmont). 2007 Oct; 4(10):16-7. PMID: 20428306.
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      57. Feifel D. An atomoxetine tutorial. Psychiatry (Edgmont). 2007 Aug; 4(8):35-8. PMID: 20532025.
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      58. Feifel D. Dosing of divalproex extended release. J Clin Psychiatry. 2007 Jul; 68(7):1146-7; author reply 1147. PMID: 17685756.
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      59. Feifel D, Melendez G, Priebe K, Shilling PD. The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro rats. Behav Brain Res. 2007 Aug 6; 181(2):278-86. PMID: 17559953.
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      60. Feifel D, Priebe K. The effects of cross-fostering on inherent sensorimotor gating deficits exhibited by Brattleboro rats. J Gen Psychol. 2007 Apr; 134(2):173-82. PMID: 17503693.
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      61. Cascade EF, Kalali AH, Feifel D. Strattera: ups, downs, and emerging uses. Psychiatry (Edgmont). 2007 Apr; 4(4):23-5. PMID: 20711324.
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      62. Feifel D. Time to feel good: the therapeutic time course of antidepressants. Psychiatry (Edgmont). 2007 Mar; 4(3):25-7. PMID: 20805906.
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      63. Feifel D. When common clinical practice meets evidence-based medicine. Psychiatry (Edgmont). 2006 Dec; 3(12):36-8. PMID: 20877554.
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      64. Minassian A, Feifel D, Perry W. The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patients. Schizophr Res. 2007 Jan; 89(1-3):225-31. PMID: 17005374.
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      65. Cascade EF, Kalali AH, Penn JV, Feifel D. Recent changes in prescriptions for antipsychotics in children and adolescents. Psychiatry (Edgmont). 2006 Sep; 3(9):18-20. PMID: 20975824.
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      66. Shilling PD, Kinkead B, Murray T, Melendez G, Nemeroff CB, Feifel D. Upregulation of striatal dopamine-2 receptors in Brattleboro rats with prepulse inhibition deficits. Biol Psychiatry. 2006 Dec 1; 60(11):1278-81. PMID: 16814260.
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      67. Ballon JS, Feifel D. A systematic review of modafinil: Potential clinical uses and mechanisms of action. J Clin Psychiatry. 2006 Apr; 67(4):554-66. PMID: 16669720.
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      68. Miller BP, Perry W, Moutier CY, Robinson SK, Feifel D. Rapid oral loading of extended release divalproex in patients with acute mania. Gen Hosp Psychiatry. 2005 May-Jun; 27(3):218-21. PMID: 15882770.
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      69. Wigal S, Swanson JM, Feifel D, Sangal RB, Elia J, Casat CD, Zeldis JB, Conners CK. A double-blind, placebo-controlled trial of dexmethylphenidate hydrochloride and d,l-threo-methylphenidate hydrochloride in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2004 Nov; 43(11):1406-14. PMID: 15502600.
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      70. Feifel D, Farber RH, Clementz BA, Perry W, Anllo-Vento L. Inhibitory deficits in ocular motor behavior in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2004 Sep 1; 56(5):333-9. PMID: 15336515.
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      71. Perry W, Minassian A, Feifel D. Prepulse inhibition in patients with non-psychotic major depressive disorder. J Affect Disord. 2004 Aug; 81(2):179-84. PMID: 15306146.
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      72. Feifel D, Melendez G, Shilling PD. Reversal of sensorimotor gating deficits in Brattleboro rats by acute administration of clozapine and a neurotensin agonist, but not haloperidol: a potential predictive model for novel antipsychotic effects. Neuropsychopharmacology. 2004 Apr; 29(4):731-8. PMID: 14760394.
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      73. Currier GW, Chou JC, Feifel D, Bossie CA, Turkoz I, Mahmoud RA, Gharabawi GM. Acute treatment of psychotic agitation: a randomized comparison of oral treatment with risperidone and lorazepam versus intramuscular treatment with haloperidol and lorazepam. J Clin Psychiatry. 2004 Mar; 65(3):386-94. PMID: 15096079.
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      74. Feifel D, Shilling PD, Kuczenski R, Segal DS. Altered extracellular dopamine concentration in the brains of cholecystokinin-A receptor deficient rats. Neurosci Lett. 2003 Sep 18; 348(3):147-50. PMID: 12932815.
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      75. Feifel D, Melendez G, Shilling PD. A systemically administered neurotensin agonist blocks disruption of prepulse inhibition produced by a serotonin-2A agonist. Neuropsychopharmacology. 2003 Apr; 28(4):651-3. PMID: 12655309.
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      76. Perry W, Feifel D, Minassian A, Bhattacharjie I, Braff DL. Information processing deficits in acutely psychotic schizophrenia patients medicated and unmedicated at the time of admission. Am J Psychiatry. 2002 Aug; 159(8):1375-81. PMID: 12153831.
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      77. Feifel D, Priebe K, Johnstone-Miller E, Morgan CJ. Sensorimotor gating effects produced by repeated dopamine agonists in a paradigm favoring environmental conditioning. Psychopharmacology (Berl). 2002 Jul; 162(2):138-46. PMID: 12110991.
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      78. Feifel D, Moutier CY, Perry W. Safety and tolerability of a rapidly escalating dose-loading regimen for risperidone. J Clin Psychiatry. 2002 Feb; 63(2):169. PMID: 11874225.
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      79. Feifel D, Priebe K, Shilling PD. Startle and sensorimotor gating in rats lacking CCK-A receptors. Neuropsychopharmacology. 2001 Jun; 24(6):663-70. PMID: 11331146.
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      80. Feifel D. Rationale and guidelines for the inpatient treatment of acute psychosis. J Clin Psychiatry. 2000; 61 Suppl 14:27-32. PMID: 11154014.
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      81. Feifel D, Reza TL. Effects of neurotensin administered into the ventral tegmental area on prepulse inhibition of startle. Behav Brain Res. 1999 Dec; 106(1-2):189-93. PMID: 10595435.
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      82. Feifel D. Individual differences in prepulse inhibition of startle as a measure of individual dopamine function. Behav Neurosci. 1999 Oct; 113(5):1020-9. PMID: 10571484.
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      83. Feifel D, Moutier CY, Swerdlow NR. Attitudes toward psychiatry as a prospective career among students entering medical school. Am J Psychiatry. 1999 Sep; 156(9):1397-402. PMID: 10484951.
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      84. Feifel D, Priebe K. The effects of subchronic haloperidol on intact and dizocilpine-disrupted sensorimotor gating. Psychopharmacology (Berl). 1999 Sep; 146(2):175-9. PMID: 10525752.
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      85. Feifel D, Reza TL, Wustrow DJ, Davis MD. Novel antipsychotic-like effects on prepulse inhibition of startle produced by a neurotensin agonist. J Pharmacol Exp Ther. 1999 Feb; 288(2):710-3. PMID: 9918579.
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      86. Feifel D, Reza T. Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating. Psychopharmacology (Berl). 1999 Jan; 141(1):93-8. PMID: 9952070.
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      87. Feifel D, Swerdlow NR. The modulation of sensorimotor gating deficits by mesolimbic cholecystokinin. Neurosci Lett. 1997 Jun 20; 229(1):5-8. PMID: 9224788.
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      88. Feifel D, Minor KL, Dulawa S, Swerdlow NR. The effects of intra-accumbens neurotensin on sensorimotor gating. Brain Res. 1997 Jun 20; 760(1-2):80-4. PMID: 9237521.
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      89. Feifel D, Reza TL, Robeck SL. Pro-dopamine effects of neurotensin on sensorimotor gating deficits. Peptides. 1997; 18(9):1457-60. PMID: 9392852.
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      90. Feifel D. Attention-deficit hyperactivity disorder in adults. Postgrad Med. 1996 Sep; 100(3):207-11, 215-8. PMID: 8795655.
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