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    Bruce Wheeler

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentBioengineering
    Address9500 Gilman Drive #0412
    CA La Jolla 92093
    Phone858-534-6458
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bhattacharya A, Desai H, DeMarse TB, Wheeler BC, Brewer GJ. Repeating Spatial-Temporal Motifs of CA3 Activity Dependent on Engineered Inputs from Dentate Gyrus Neurons in Live Hippocampal Networks. Front Neural Circuits. 2016; 10:45. PMID: 27445701.
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      2. DeMarse TB, Pan L, Alagapan S, Brewer GJ, Wheeler BC. Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks. Front Neural Circuits. 2016; 10:32. PMID: 27147977.
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      3. Alagapan S, Franca E, Pan L, Leondopulos S, Wheeler BC, DeMarse TB. Structure, Function, and Propagation of Information across Living Two, Four, and Eight Node Degree Topologies. Front Bioeng Biotechnol. 2016; 4:15. PMID: 26973833.
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      4. Pan L, Alagapan S, Franca E, Leondopulos SS, DeMarse TB, Brewer GJ, Wheeler BC. An in vitro method to manipulate the direction and functional strength between neural populations. Front Neural Circuits. 2015; 9:32. PMID: 26236198.
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      5. Dhawan AP, Heetderks WJ, Pavel M, Acharya S, Akay M, Mairal A, Wheeler B, Dacso CC, Sunder T, Lovell N, Gerber M, Shah M, Senthilvel SG, Wang MD, Bhargava B. Current and Future Challenges in Point-of-Care Technologies: A Paradigm-Shift in Affordable Global Healthcare With Personalized and Preventive Medicine. IEEE J Transl Eng Health Med. 2015; 3:2800110. PMID: 27170902; PMCID: PMC4848045.
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        View in: PubMed Central
      6. Pan L, Alagapan S, Franca E, DeMarse T, Brewer GJ, Wheeler BC. Large extracellular spikes recordable from axons in microtunnels. IEEE Trans Neural Syst Rehabil Eng. 2014 May; 22(3):453-9. PMID: 24240004.
        View in: PubMed
      7. Brewer GJ, Boehler MD, Leondopulos S, Pan L, Alagapan S, DeMarse TB, Wheeler BC. Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3. Front Neural Circuits. 2013; 7:165. PMID: 24155693.
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      8. Leondopulos SS, Boehler MD, Wheeler BC, Brewer GJ. Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies. J Neural Eng. 2012 Apr; 9(2):026015. PMID: 22361724.
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      9. Dhawan AP, Wheeler BC. Editorial: introducing TBME Letters special section on multiscale biomedical signal and image modeling and analysis. IEEE Trans Biomed Eng. 2012 Jan; 59(1):3. PMID: 22186182.
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      10. Boehler MD, Leondopulos SS, Wheeler BC, Brewer GJ. Hippocampal networks on reliable patterned substrates. J Neurosci Methods. 2012 Jan 30; 203(2):344-53. PMID: 21985763.
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      11. Pan L, Alagapan S, Franca E, Brewer GJ, Wheeler BC. Propagation of action potential activity in a predefined microtunnel neural network. J Neural Eng. 2011 Aug; 8(4):046031. PMID: 21750372.
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      12. Wheeler B, Thakor N, He B. Special section on Grand Challenges in Neuroengineering. IEEE Trans Biomed Eng. 2011 Jul; 58(7):1883. PMID: 21693386.
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      13. Nam Y, Wheeler BC. In vitro microelectrode array technology and neural recordings. Crit Rev Biomed Eng. 2011; 39(1):45-61. PMID: 21488814.
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      14. Wheeler BC, Brewer GJ. Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes. Proc IEEE Inst Electr Electron Eng. 2010 Mar 1; 98(3):398-406. PMID: 21625406.
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      15. Ide AN, Andruska A, Boehler M, Wheeler BC, Brewer GJ. Chronic network stimulation enhances evoked action potentials. J Neural Eng. 2010 Feb; 7(1):16008. PMID: 20083862.
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      16. Dhawan AP, Wheeler BC. Introducing TBME letters and regular papers special issue on therapeutic ultrasound. IEEE Trans Biomed Eng. 2010 Jan; 57(1):3. PMID: 20064752.
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      17. Brewer GJ, Boehler MD, Ide AN, Wheeler BC. Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates. J Neurosci Methods. 2009 Oct 30; 184(1):104-9. PMID: 19666055.
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      18. Musick K, Khatami D, Wheeler BC. Three-dimensional micro-electrode array for recording dissociated neuronal cultures. Lab Chip. 2009 Jul 21; 9(14):2036-42. PMID: 19568672.
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      19. Brewer GJ, Boehler MD, Pearson RA, DeMaris AA, Ide AN, Wheeler BC. Neuron network activity scales exponentially with synapse density. J Neural Eng. 2009 Feb; 6(1):014001. PMID: 19104141.
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      20. Nam Y, Brown EA, Ross JD, Blum RA, Wheeler BC, DeWeerth SP. A retrofitted neural recording system with a novel stimulation IC to monitor early neural responses from a stimulating electrode. J Neurosci Methods. 2009 Mar 30; 178(1):99-102. PMID: 19100770.
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      21. Dworak BJ, Wheeler BC. Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture. Lab Chip. 2009 Feb 7; 9(3):404-10. PMID: 19156289.
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      22. Brown EA, Ross JD, Blum RA. Stimulus-artifact elimination in a multi-electrode system. IEEE Trans Biomed Circuits Syst. 2008 Mar; 2(1):10-21. PMID: 23852629.
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      23. Brewer GJ, Boehler MD, Jones TT, Wheeler BC. NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. J Neurosci Methods. 2008 May 30; 170(2):181-7. PMID: 18308400.
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      24. Wheeler BC. Building a brain on a chip. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:1604-6. PMID: 19162982.
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      25. Boehler MD, Wheeler BC, Brewer GJ. Added astroglia promote greater synapse density and higher activity in neuronal networks. Neuron Glia Biol. 2007 May; 3(2):127-40. PMID: 18345351.
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      26. Vieira M, Christensen BL, Wheeler BC, Feng AS, Kollmar R. Survival and stimulation of neurite outgrowth in a serum-free culture of spiral ganglion neurons from adult mice. Hear Res. 2007 Aug; 230(1-2):17-23. PMID: 17521837.
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      27. Rowe L, Almasri M, Lee K, Fogleman N, Brewer GJ, Nam Y, Wheeler BC, Vukasinovic J, Glezer A, Frazier AB. Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks. Lab Chip. 2007 Apr; 7(4):475-82. PMID: 17389964.
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      28. Nam Y, Brewer GJ, Wheeler BC. Development of astroglial cells in patterned neuronal cultures. J Biomater Sci Polym Ed. 2007; 18(8):1091-100. PMID: 17706000.
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      29. Nam Y, Musick K, Wheeler BC. Application of a PDMS microstencil as a replaceable insulator toward a single-use planar microelectrode array. Biomed Microdevices. 2006 Dec; 8(4):375-81. PMID: 16799748.
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      30. Chang JC, Brewer GJ, Wheeler BC. Neuronal network structuring induces greater neuronal activity through enhanced astroglial development. J Neural Eng. 2006 Sep; 3(3):217-26. PMID: 16921205.
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      31. Nam Y, Branch DW, Wheeler BC. Epoxy-silane linking of biomolecules is simple and effective for patterning neuronal cultures. Biosens Bioelectron. 2006 Dec 15; 22(5):589-97. PMID: 16531038.
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      32. Nam Y, Wheeler BC, Heuschkel MO. Neural recording and stimulation of dissociated hippocampal cultures using microfabricated three-dimensional tip electrode array. J Neurosci Methods. 2006 Sep 15; 155(2):296-9. PMID: 16494949.
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      33. Ewert D, Wheeler B, Doetkott C, Ionan C, Pantalos G, Koenig SC. The effect of heart rate, preload, and afterload on the viscoelastic properties of the swine myocardium. Ann Biomed Eng. 2004 Sep; 32(9):1211-22. PMID: 15493509.
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      34. Nam Y, Chang J, Khatami D, Brewer GJ, Wheeler BC. Patterning to enhance activity of cultured neuronal networks. IEE Proc Nanobiotechnol. 2004 Jun; 151(3):109-15. PMID: 16475852.
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      35. Lockwood ME, Jones DL, Bilger RC, Lansing CR, O'Brien WD, Wheeler BC, Feng AS. Performance of time- and frequency-domain binaural beamformers based on recorded signals from real rooms. J Acoust Soc Am. 2004 Jan; 115(1):379-91. PMID: 14759029.
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      36. Khatami D, Nam Y, Brewer G, Wheeler B. Effect of bicuculline on the spontaneous and evoked activity of patterned embryonic hippocampal neurons cultured in vitro. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4059-62. PMID: 17271191.
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      37. Wheeler BC, Nam Y, Brewer GJ. Patterning to influence in vitro neuronal interfaces. Conf Proc IEEE Eng Med Biol Soc. 2004; 7:5337-9. PMID: 17271547.
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      38. Nam Y, Chang JC, Wheeler BC, Brewer GJ. Gold-coated microelectrode array with thiol linked self-assembled monolayers for engineering neuronal cultures. IEEE Trans Biomed Eng. 2004 Jan; 51(1):158-65. PMID: 14723505.
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      39. Nam Y, Wheeler BC. Multichannel recording and stimulation of neuronal cultures grown on microstamped poly-D-lysine. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4049-52. PMID: 17271188.
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      40. Ratnam R, Jones DL, Wheeler BC, O'Brien WD, Lansing CR, Feng AS. Blind estimation of reverberation time. J Acoust Soc Am. 2003 Nov; 114(5):2877-92. PMID: 14650022.
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      41. Chang JC, Brewer GJ, Wheeler BC. A modified microstamping technique enhances polylysine transfer and neuronal cell patterning. Biomaterials. 2003 Aug; 24(17):2863-70. PMID: 12742724.
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      42. Cornish T, Branch DW, Wheeler BC, Campanelli JT. Microcontact printing: a versatile technique for the study of synaptogenic molecules. Mol Cell Neurosci. 2002 May; 20(1):140-53. PMID: 12056845.
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      43. Liu C, Wheeler BC, O'Brien WD, Lansing CR, Bilger RC, Jones DL, Feng AS. A two-microphone dual delay-line approach for extraction of a speech sound in the presence of multiple interferers. J Acoust Soc Am. 2001 Dec; 110(6):3218-31. PMID: 11785823.
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      44. Chang JC, Brewer GJ, Wheeler BC. Modulation of neural network activity by patterning. Biosens Bioelectron. 2001 Sep; 16(7-8):527-33. PMID: 11544046.
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      45. Branch DW, Wheeler BC, Brewer GJ, Leckband DE. Long-term stability of grafted polyethylene glycol surfaces for use with microstamped substrates in neuronal cell culture. Biomaterials. 2001 May; 22(10):1035-47. PMID: 11352085.
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      46. Liu C, Wheeler BC, O'Brien WD, Bilger RC, Lansing CR, Feng AS. Localization of multiple sound sources with two microphones. J Acoust Soc Am. 2000 Oct; 108(4):1888-905. PMID: 11051515.
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      47. Branch DW, Wheeler BC, Brewer GJ, Leckband DE. Long-term maintenance of patterns of hippocampal pyramidal cells on substrates of polyethylene glycol and microstamped polylysine. IEEE Trans Biomed Eng. 2000 Mar; 47(3):290-300. PMID: 10743770.
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      48. Wheeler BC, Corey JM, Brewer GJ, Branch DW. Microcontact printing for precise control of nerve cell growth in culture. J Biomech Eng. 1999 Feb; 121(1):73-8. PMID: 10080092.
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      49. Branch DW, Corey JM, Weyhenmeyer JA, Brewer GJ, Wheeler BC. Microstamp patterns of biomolecules for high-resolution neuronal networks. Med Biol Eng Comput. 1998 Jan; 36(1):135-41. PMID: 9614762.
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      50. Corey JM, Brunette AL, Chen MS, Weyhenmeyer JA, Brewer GJ, Wheeler BC. Differentiated B104 neuroblastoma cells are a high-resolution assay for micropatterned substrates. J Neurosci Methods. 1997 Jul 18; 75(1):91-7. PMID: 9262149.
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      51. Corey JM, Wheeler BC, Brewer GJ. Micrometer resolution silane-based patterning of hippocampal neurons: critical variables in photoresist and laser ablation processes for substrate fabrication. IEEE Trans Biomed Eng. 1996 Sep; 43(9):944-55. PMID: 9214810.
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      52. Boppart SA, Wheeler BC, Wallace CS. A flexible perforated microelectrode array for extended neural recordings. IEEE Trans Biomed Eng. 1992 Jan; 39(1):37-42. PMID: 1572679.
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      53. Corey JM, Wheeler BC, Brewer GJ. Compliance of hippocampal neurons to patterned substrate networks. J Neurosci Res. 1991 Oct; 30(2):300-7. PMID: 1798054.
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      54. Willming DA, Wheeler BC. Real-time multichannel neural spike recognition with DSPs. IEEE Eng Med Biol Mag. 1990; 9(1):37-9. PMID: 18238315.
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      55. Novak JL, Wheeler BC. Two-dimensional current source density analysis of propagation delays for components of epileptiform bursts in rat hippocampal slices. Brain Res. 1989 Sep 18; 497(2):223-30. PMID: 2819422.
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      56. Novak JL, Wheeler BC. A high-speed multichannel neural data acquisition system for IBM PC compatibles. J Neurosci Methods. 1989 Jan; 26(3):239-47. PMID: 2918748.
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      57. Smith SR, Wheeler BC. A real-time multiprocessor system for acquisition of multichannel neural data. IEEE Trans Biomed Eng. 1988 Oct; 35(10):875-7. PMID: 3192237.
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      58. Novak JL, Wheeler BC. Multisite hippocampal slice recording and stimulation using a 32 element microelectrode array. J Neurosci Methods. 1988 Mar; 23(2):149-59. PMID: 3357355.
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      59. Wheeler BC, Smith SR. High-resolution alignment of action potential waveforms using cubic spline interpolation. J Biomed Eng. 1988 Jan; 10(1):47-53. PMID: 3347033.
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      60. Wheeler BC, Novak JL. Current source density estimation using microelectrode array data from the hippocampal slice preparation. IEEE Trans Biomed Eng. 1986 Dec; 33(12):1204-12. PMID: 3817854.
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      61. Novak JL, Wheeler BC. Recording from the Aplysia abdominal ganglion with a planar microelectrode array. IEEE Trans Biomed Eng. 1986 Feb; 33(2):196-202. PMID: 3007331.
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      62. Wheeler BC, Valesano WR. Real-time digital-filter-based data-acquisition system for the detection of neural signals. Med Biol Eng Comput. 1985 May; 23(3):243-8. PMID: 3839551.
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      63. Wheeler BC, Heetderks WJ. A comparison of techniques for classification of multiple neural signals. IEEE Trans Biomed Eng. 1982 Dec; 29(12):752-9. PMID: 7173942.
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